Clinical Research Update: Stem Cell Treatment for Heart Failure in Cancer Survivors

Heart failure induced by cancer treatments is often irreversible, and disproportionately affects women and young adults. Texas Heart Institute’s Medical Director, Dr. Emerson Perin, and colleagues across the U.S. evaluated a new treatment approach, using allogeneic, bone marrow-derived stem cell treatment, which was safe and might improve heart function. The research lays the groundwork for further testing in clinical trials. The SENECA Trial was a Phase 1, first-in-human study of allogeneic mesenchymal stromal cells (allo-MSCs) in patients with anthracycline-induced cardiomyopathy (AIC). Results were presented at the annual Heart Failure Society of America meeting held virtually this year and appeared in JACC Cardio-Oncology this month. 


Read the Full Study:

JACC: CardioOncology September 2020 DOI: 10.1016/j.jaccao.2020.09.001

A Phase I Study of Allogeneic Mesenchymal Stem Cell Therapy in Patients with Heart Failure Secondary to Anthracycline-induced Cardiomyopathy: The Cctrn Stem Cell Injection in Cancer Survivors (Seneca) Trial



The Texas Heart Institute, founded by world-renowned cardiovascular surgeon Dr. Denton A. Cooley in 1962, is a nonprofit organization dedicated to reducing the devastating toll of cardiovascular disease through innovative and progressive programs in research, education, and improved patient care. THI’s scientists and physicians conduct fundamental biomedical, translational, and clinical research in cardiology, cardiovascular surgery, molecular-based medicine, stem cell, and gene therapy, and regenerative medicine both independently and in collaboration with organizations worldwide. As global leaders of patient care for nearly six decades, Texas Heart Institute has been ranked among the top cardiovascular centers in the United States by U.S. News & World Report for the past 30 years. THI is dedicated to spreading awareness and sharing updates on ways to prevent, treat, and defeat cardiovascular disease. With over 10 million visitors coming to its website from around the world every year, is just one of the ways THI is helping to educate people on the importance of heart health. For more information, please visit