Grand Rounds | 2024-2025

A Change of Heart: From Genetics of Heart Disease to New Therapeutics

Deepak Srivastava, MD, FAHA

President and Senior Investigator
Director, Roddenberry Stem Cell Center
Robert W. and Linda Mahley Distinguished Professorship
Gladstone Institutes
San Francisco, California

Wilma and Adeline Pirag Distinguished Professor in Pediatric Development Cardiology
Professor, Pediatrics and Biochemistry and Biophysics
University of California, San Francisco

Pediatric Cardiologist
UCSF Benioff Children’s Hospitals

Nonresident Scholar for Biomedical Research Policy
The Baker Institute for Public Policy
Rice University
Houston, Texas

Note: CME credits & MOC points will not be awarded for this presentation.

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Aortic Root Pathology: Where Are We?

Joseph S. Coselli, MD, FACS

Professor and Executive Vice Chair
Department of Surgery
Cullen Foundation Endowed Chair
Program Director, Aortic Surgery Fellowship
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center

Academic Professional Staff
The Texas Heart Institute
Houston, Texas

Overview:

We will discuss the role of aortic root replacement and the challenges, including the use of TAVR.

Objectives:

At the conclusion of the activity a participant should be able to:

• Examine the circumstances and etiology of root degeneration.
• Review the basics of aortic root replacement.
• Identify the results of the various root surgical therapies.

Disclosures:

Joseph S. Coselli, MD, is a researcher, advisor, consultant, and speaker for, and receives honoraria and royalties from, Terumo Aortic. He is an investigator for Medtronic, W.L. Gore and Associates, Inc., and Artivion, Inc.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

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The Future of Cardiovascular Disease: Will Artificial Intelligence Replace Cardiologists and Vascular Specialists?

Tony S. Das, MD, FACC

Founder and CEO, Connected Cardiovascular Care Associates
Chief, Cardiovascular Strategic Planning and Development
Baylor Scott & White Health
Dallas, Texas

Overview:

Dr. Das will discuss the potential implications of Artificial Intelligence (AI) for the future diagnosis and treatment of cardiovascular disease.

Objectives:

At the conclusion of the activity a participant should be able to:

• Define terminology related to Artificial Intelligence.
• Evaluate new technologies for cardiovascular diagnosis and treatment from an AI standpoint.
• Discuss potential uses of AI for vascular specialists.

Disclosures:

Tony Das, MD, FACC, is a consultant for Arineta, Heartflow, and Elucid. He is a Board Member for Acarix.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Aortic Regurgitation: The Changing Landscape of Diagnosis & Management

William A. Zoghbi, MD, FASE, FAHA, MACC

Chair, Department of Cardiology
Houston Methodist DeBakey Cardiology Associates
Elkins Family Distinguished Chair in Cardiac Health
Houston Methodist DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College
Houston, Texas

Overview:

Dr. Zoghbi will review the etiologies of aortic regurgitation, new developments in assessing regurgitation severity and adaptation of the heart, and the latest in management.

Objectives:

At the conclusion of the activity a participant should be able to:

• Review the incidence, various etiologies, and clinical manifestations of aortic regurgitation.
• Discuss criteria for aortic regurgitation severity with doppler echocardiography as well as cardiac MR and share the evolving changes in criteria of severity that impact the patient outcomes.
• Discuss current ACC/AHA guidelines of management of significant aortic regurgitation and the merging impact of cardiovascular imaging in modulating treatment strategies with surgical or percutaneous interventions.

Disclosures:

William A. Zoghbi, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

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A New Digital Era in Cardiovascular Interventions

Yiannis S. Chatzizisis, MD, PhD, FACC, FAHA, FSCAI, FESC

Chief, Division of Cardiovascular Medicine
Professor of Medicine
Director, Center for Digital Cardiovascular Innovations
University of Miami Health System
Leonard M. Miller School of Medicine
University of Miami
Miami, Florida

Overview:

Dr. Chatzizisis will introduce 21st century digital technologies and discuss the role of digital technologies in clinical decision making and pre-procedural planning. He will explain the role of digital technologies in device R&D and regulatory approval, as well as use of artificial intelligence and computational simulations in education and training.

Objectives:

At the conclusion of the activity a participant should be able to:

• Discuss the role of digital technologies in clinical decision making and pre-procedural planning.
• Describe the role of digital technologies in device R&D and regulatory approval.
• Discuss the use of artificial intelligence and computational simulations in education and training.

Disclosures:

Yiannis S. Chatzizisis, MD, PhD, is a consultant and received honoraria from Boston Scientific and Medtronic.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Carbon Nanotube Fibers Reduce Scar-Based Reentrant Arrhythmias

Mark McCauley, MD, PhD

Associate Professor of Medicine
Director, Electrophysiology Program
Department of Medicine, Division of Cardiology
University of Illinois College of Medicine
University of Illinois Chicago
University of Illinois Hospital
Jesse Brown VA Medical Center
Chicago, Illinois

Overview:

Carbon nanotube fibers (CNT) hold immense promise in restoring electrical conduction within the heart and reducing arrhythmias.

Objectives:

At the conclusion of the activity a participant should be able to:

• Describe the mechanisms of reentry in the heart.
• Describe how CNT fibers promote cardiac conduction within the heart.
• Apply CNT based conduction to reduce atrial and ventricular arrhythmias.

Disclosures:

Mark McCauley, MD, PhD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Clinical and Imaging Characteristics of Chagas Cardiomyopathy

Carlos Morillo, MD, FRCPC, FACC, FHRS, FESC

Professor, Department of Cardiac Sciences and Medicine
Section Chief, Cardiology Division
Libin Cardiovascular Institute of Alberta
Cummings School of Medicine
University of Calgary
Zone Head Cardiology
Calgary & Southeastern Alberta Region
Alberta Health Services
Calgary Alberta, Canada

Overview:

Chagas cardiomyopathy is caused by infection with Trypanosoma cruzi. Chagas has an acute and chronic stage that is associated with a rapidly progressive cardiomyopathy characterized by conduction disorders, ventricular tachycardia and refractory and progressive heart failure. Imaging can play a role in identifying subjects that will progress to cardiomyopathy and stratify risk of sudden cardiac death (SCD). The clinical presentation, management and role of imaging in Chagas cardiomyopathy will be reviewed in this presentation.

Objectives:

At the conclusion of the activity a participant should be able to:

• Determine the pathophysiology of Chagas disease and chronic Chagas cardiomyopathy.
• Describe the role of etiologic treatment in Chagas disease.
• Summarize the role of cardiac imaging (Echo and CMRI) in identifying patients that will progress to overt cardiomyopathy and risk stratify patients at risk of SCD.

Disclosures:

Carlos A. Morillo, MD, has nothing to disclose relevant to this program.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CME credits must be claimed within 24 hours after a live conference.

Multimodality Imaging of Pericardiac Diseases & Targeted Therapy

Allan L. Klein, MD, FRCP(C), FACC, FAHA, FASE, FESC

Professor of Medicine
Director, Center for the Diagnosis and Treatment of Pericardial Diseases
Director, Cardiovascular Imaging Research
Staff Cardiologist, Section of Cardiovascular Imaging
Robert and Suzanne Tomsich Department of Cardiovascular Medicine
Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute
Cleveland Clinic
Cleveland, Ohio

Overview:

Dr. Klein will discuss the new concepts and role of multimodality imaging in guiding therapy in pericarditis.

Objectives:

At the conclusion of the activity a participant should be able to:

• Discuss new concepts in pericardial disease.
• Describe the role of multimodality imaging in pericarditis.
• Discuss new therapeutics in recurrent pericarditis.

Disclosures:

Allan L. Klein, MD, received research grants from and is on the advisory boards for Kiniska Pharmaceuticals and Cardiol Therapeutics. He is also on the advisory board for Pfizer. Dr. Klein received royalties from Wolters Kluwer Elsevier.

The Planning Committee has nothing to disclose relevant to this program.

The Texas Heart Institute CME Staff has nothing to disclose relevant to this program.

The Program Reviewers have nothing to disclose relevant to this program.

All relevant financial relationships have been mitigated.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC Credit

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Successful completion is a passing grade of 70% on the assessment in the CME evaluation.

CME credits & MOC points must be claimed within 24 hours after a live conference.

Cloud-Based Monitoring and Rapid Response – Innovations and Outcomes

James Herlihy, MD

Professor
Medicine – Pulmonary
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Marc R. Moon, MD

Professor, Surgery
Chief, Division of Cardiothoracic Surgery
Baylor College of Medicine
Chief, Adult Cardiac Surgery Section
St. Luke’s Health – Baylor St. Luke’s Medical Center

Academic Professional Staff
Chief, Adult Cardiac Surgery
The Texas Heart Institute

Denton A. Cooley, MD Chair in Cardiac Surgery
St. Luke’s Foundation
Houston, Texas

Ajay Kirtane, MD, SM, FSCAI

Professor of Medicine
Columbia University Irving Medical Center
Director and Chief Academic Officer
Columbia Interventional Cardiovascular Care Program
Seymour, Paul and Gloria Milstein Division of Cardiology
Columbia University Department of Medicine
New York, New York

Mourad H. Senussi, MD, MS

Academic Professional Staff
The Texas Heart Institute
Assistant Professor
Medicine – Cardiology & Critical Care Medicine
Baylor College of Medicine
Medical Director of CICU
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas

Patrick T. O’Gara, MD, MACC, FAHA, FESC

Watkins Family Distinguished Chair in Cardiology
Professor, Harvard Medical School
Cardiovascular Medicine
Director of Strategic Planning, Cardiovascular Division
Brigham and Women’s Hospital
Boston, Massachusetts

Mathew Maurer, MD, FACC

Arnold and Arlene Goldstein Professor of Cardiology
Director, Clinical Cardiovascular Research Laboratory for the Elderly
CUIMC/Vivian & Seymour Milstein Family Heart Center
Columbia University Irving Medical Center
Vagelos College of Physicians & Surgeons
Director, Cardiac Amyloidosis Program
Advanced Cardiac Care Center
NewYork Presbyterian Hospital – Columbia Campus
New York, New York

Roxana Mehran, MD, FACC, FACP, FCCP, FESC, FAHA, FSCAI

Professor of Medicine, Cardiology and Population Health Science and Policy
Professor in Cardiovascular Clinical Research and Outcomes
Director, Interventional Cardiovascular Research and Clinical Trials
Zena and Michael A. Wiener Cardiovascular Institute
Icahn School of Medicine at Mount Sinai
Mount Sinai Health System
New York, New York

Biswajit Kar, MD

Professor, Internal Medicine
Memorial Hermann Chair
Center for Advanced Cardiopulmonary Therapies and Transplantation
McGovern Medical School
The University of Texas Health Science Center at Houston (UTHealth Houston)
Chief, Medical Division, Center for Advanced Heart Failure
Memorial Hermann Heart & Vascular Institute
Memorial Hermann Hospital
Houston, Texas

Martin S. Maron, MD

Assistant Professor of Medicine
Division of Cardiology
Tufts University School of Medicine
Medical Director, Hypertrophic Cardiomyopathy Center
Lahey Hospital & Medical Center
Beth Israel Lahey Health
Burlington, Massachusetts

Jeffrey L. Carson, MD, MACP

Provost, New Brunswick, Rutgers Biomedical Health Sciences
Distinguished Professor of Medicine
Richard C. Reynolds, MD, Chair in General Internal Medicine
Robert Wood Johnson Medical School
Rutgers Health
New Brunswick, New Jersey

Faisal Bakaeen, MD

Professor of Surgery
Cleveland Clinic Lerner College of Medicine
Sheikh Hamdan bin Rashid Al Maktoum Distinguished Chair in Thoracic and Cardiovascular Surgery
Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute
Cleveland Clinic
Cleveland, Ohio

L. Maximilian Buja, MD

Academic Professional Staff
Chief, Cardiovascular Pathology Research
The Texas Heart Institute
Dean Emeritus
Professor of Pathology
McGovern Medical School
The University of Texas Health Science Center at Houston (UTHealth Houston)
Houston, Texas

Joseph G. Rogers, MD

President and Chief Executive Officer
O’Quinn/Willerson Endowed Chair
The Texas Heart Institute
The Texas Heart Institute Center for Cardiovascular Care
Faculty, Medicine
Baylor College of Medicine
St. Luke’s Health – Baylor St. Luke’s Medical Center
Houston, Texas