3rd Annual International Symposium on Cardiovascular Regenerative Medicine

May 12-13 | Live + Panel Discussions

In the context of the current landscape of the field of clinical regenerative medicine, it is important for investigators to share new findings, discuss and debate the state of the field to direct further development, and build the framework for clinical implementation. This meeting will provide an important forum for these activities.

Unlike areas with recognized, evidence-based knowledge, the field of clinical stem cell therapy is a nascent field in which most of the competence and performance issues are unestablished. We have the need for knowledge and application of that knowledge to establish successful strategies in clinical regenerative medicine.

This symposium aims to advance the field of cardiovascular regenerative medicine through scholarly debates, discussion, and the establishment of a new platform of understanding from which to move the field forward.

This two-day symposium will include advanced lectures, dynamic case presentations, a live lab presentation from leaders in each field, and the opportunity to interact with leaders in an intimate meeting format.

Faculty

The Texas Heart Institute
Houston, Texas

Hospital General Universitario,
Gregorio Maranon
Madrid, Spain

Hospital General Universitario
Gregorio Maranon
Madrid, Spain

Hospital General Universitario Gregorio Marañón
Madrid, Comunidad de Madrid, Spain

Professor of Cardiology
Leiden University Medical Center
The Netherlands

Associate Director
Cardiovascular Center
OLV Hospital
Belgium

Editor-in-Chief, Molecular and Cellular Biochemistry
Professor of Medicine and Physiology
Distinguished University Scholar
Jewish Hospital Distinguished Chair in Cardiology
Director, Institute of Molecular Cardiology
Past President, International Academy of Cardiovascular Sciences
Unicweaity of Louisville Medical School
Louisville, Kentucky

New York, USA

Professor, Shu Chien-Gene Lay Department of Bioengineering
Pierre Galletti Endowed Chair for Bioengineering Innovation
Associate Dean for Faculty, Jacobs School of Engineering
Sanford Consortium for Regenerative Medicine
University of California San Diego
California

Executive Liaison
Texas Medical Center
Houston, Texas

Professor of Regenerative Muscle Physiology
King’s College London
London

Louis Lemberg Professor of Medicine/Director, Interdisciplinary Stem Cell Institute
University of Miami Miller School of Medicine
Miami, Florida

Medical Director, The Carl and Edyth Lindner Center for Research and Education
The Carl and Edyth Lindner Family Distinguished Chair in Clinical Research
Director of Programmatic and Network Development
The Christ Hospital Health Network
Cincinnati, Ohio

The Texas Heart Institute
Houston, Texas

Tenaya Therapeutics
UT Southwestern Medical Center
San Francisco, California

Professor of Cardiology
Chair Department of Cardiovascular Diseases
University of Leuven, Belgium.
Leuven, Belgium

Director of Cardiac Stem Cell Centre
Cardiac Catheterization Laboratory
University of Copenhagen
Copenhagen, Denmark

Professor
Baylor College of Medicine
The Texas Heart Institute
Houston, Texas

Professor of Cardiovascular Medicine UCL
Honorary Consultant Physician UCL Hospitals
University College London
London

Service de Chirurgie Cardiovasculaire
Hôpital Européen Georges Pompidou
Paris, France

University of South Florida College
of Medicine
Tampa, Florida

Program Director, Cardiovascular Medicine Fellowship
Summa Health and Vascular Institute
Akron, Ohio

University of Florida,
Gainesville, Florida

Baylor College of Medicine
The Texas Heart Institute
Houston, Texas

The Texas Heart Institute
Houston, Texas

Professor of Cardiology – Head of Heart Failure Department
University of Toulouse
Toulouse, France

The Texas Heart Institute
Houston, Texas

Director of Stem Cell Biology
Bruce R. Logue Professor
Division of Cardiology
Department of Medicine
Emory University
Atlanta, Georgia

Distinguished Professor of Biology
SDSU Heart Institute and Biology Department
San Diego State University
San Diego, California

Professor of Cardiology
Head, Molecular and Cellular Cardiology Institute
Department of Experimental and Clinical Medicine
University Magna Graecia (UMG)
Italy

University of Medical Center
Ljubljana, Slovenia

Director, Stanford Cardiovascular Institute
Simon H. Stertzer, MD, Professor of Medicine & Radiology
Stanford University School of Medicine
Stanford, California

Chair, Department of Biomedical Engineering
T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership
Professor of Medicine, of Engineering
School of Medicine, School of Engineering
The University of Alabama at Birmingham (UAB)
Birmingham, Alabama

Prof. Dr. Wolfram-Hubertus Zimmermann
Director, Institute of Pharmacology and Toxicology
University Medical Center Göttingen
Germany

Agenda

Agenda subject to change

Friday – May 12, 2023

7:30 am       Registration and Breakfast

7:45              Welcome | Emerson Perin, MD, PhD

OPENING SESSION: Cardiovascular Regeneration and Repair: Needs and Hopes | Chairs: Emerson Perin, MD, PhD; Francisco FernandezAviles, MD, PhD and Joseph G. Rogers, MD

8:00            Keynote: Fostering a Culture of Physician Innovation | William Cohn, MD 

8:30            Quick Perspective on the State of the Field of Cell Therapy | Emerson Perin, MD, PhD

8:35             Rapid History & Future of Regenerative Medicine for the Heart | Francisco Fernandez-Aviles, MD, PhD

8:40            Panel Discussion

Special Lecture

9:10            Setting the Stage for Cell Therapy in HF | Joseph G. Rogers, MD

SESSION I: Picking Up Where We Left Off: Clinical Advances in Cell Therapy and Regenerative Medicine Over the Last 3 Years Ongoing and Recently Completed Trials | Chairs: Ricardo Sanz-Ruiz, MD, PhD and Leslie Miller, MD

9:20           Dream-HF: Main Results | Emerson Perin, MD, PhD

9:30           MSC-HF 4 Years Later/ SCIENCE | Jens Kastrup, MD

9:40           DCM II Trial | Joshua Hare, MD

9:50           Panel Discussion

10:10         Myocyte Trial | Ricardo Sanz-Ruiz, MD, PhD

10:20         CD 34 and Microvascular Angina | Timothy Henry, MD

10:30         Cardi-AMP | Carl Pepine, MD

10:40         Embryonic Cells for HF | Joseph Wu, MD, PhD

10:50         Panel Discussion

SESSION II: Advances in Translational Regenerative Medicine | Chairs: Camila Hochman-Mendez, PhD and Timothy Henry, MD 

11:10         Neonatal Heart Regeneration | Jay Zhang, MD, PhD

11:20         IV Cell Therapy for HF | Roberto Bolli, MD

11:30         IPS | Young-sup Yoon, MD, PhD

11:40         Panel Discussion

12:00         Lunch

SESSION III: New Perspectives | Chairs: Emerson Perin, MD, PhD and Roberto Bolli, MD 

1:00           Inflammation in HFpEF: Circumstantial or Key? | Matthew Segar, MD

1:10           Cell Therapy in HFpEF | Bojan Vrtovec, MD, PhD

1:20           LVAD and MPC Therapy | Ken Borow, MD

1:30           CSC’s and Arrhythmogenic Scar | Angel Arenal, MD

1:40           Surgical Delivery of Embryonic Cells/Products | Philippe Menasche, MD, PhD

1:50           Panel Discussion

SESSION IV: Roundtable | Introduction and Moderator: Stefan Janssens, MD, PhD

2:20           3 Important Questions to Consider in Regenerative Medicine | Francisco Fernandez-Aviles, MD, PhD; Roberto Bolli, MD; Joshua Hare, MD; Tim Henry, MD; Jens Kastrup, MD; Philippe Menasche, MD, PhD and Emerson Perin, MD, PhD

SESSION V: Regenerative Medicine in Organizations | Chairs: Francisco Fernandez-Aviles, MD, PhD and Joshua Hare, MD

3:00          TACTICS and Beyond: The ESC WG on CR&RM | Ricardo Sanz-Ruiz, MD, PhD

3:10           BRAV3 Consortium | Ricardo Sanz-Ruiz, MD, PhD

3:20           Netherlands: State of Cell Therapy | Douwe Atsma, MD, PhD

3:30           Panel Discussion

3:50           Adjourn

6:00 pm    Dinner at Wiess Energy Hall – Museum of Natural Sciences

Saturday – May 13, 2023

8:00 am    Registration and Breakfast

SESSION VI: The Ongoing Dilemma of Intramyocardial Delivery | Chairs: Ricardo Sanz-Ruiz, MD, PhD and Jerome Roncalli, MD, PhD

8:30          The Story of NOGA and Delivery: Targeting Necessary? | Emerson Perin, MD, PhD

8:40          Is C-Cath a Viable Alternative? | Jozef Bartunek, MD, PhD

8:50          Live Case Demonstration: New Tenaya Catheter w/Mapping Co-Registration | Emerson Perin, MD, PhD

9:20          Panel Discussion

SESSION VIIA: Issues with The Tissues | Chairs: Stefan Janssens, MD, PhD; Philippe Menasche, MD, PhD and Jens Kastrup, MD  

9:40          Ploidy and Myocardial Repair | Mark Sussman, PhD

9:50          MVO and Regeneration | Jerome Roncalli, MD, PhD

10:00       Adult Cardiac Stem/Progenitor Cells Revisited: The Baby and the Bathwater | Daniele Torella, MD, PhD

10:10        Tissue Engineering and Beyond | Wolfram H. Zimmermann, MD

SESSION VIIB: Repair Without Cells

10:20        Intravascularly Infused Biomaterials for Treating Myocardial Infarction | Karen Christman, PhD

10:30        Targeting Cell Senescence to Improve Cardiac Regeneration | Georgina Ellison-Hughes, PhD

10:40        Panel Discussion

SESSION VIII: Gene Therapy | Chairs: Jim Martin, MD, PhD and Joseph Wu, MD, PhD

11:00        Back to the Future – Driving Paracrine Function in Regenerative Therapy | Marc Penn, MD, PhD

11:10         VEGF in Refractory Angina | Emerson Perin, MD, PhD

11:20         Hippo Pathway Inhibition | James Martin, MD, PhD

11:30         Cardiac Reprogramming | Kathy Ivey, PhD

11:40         Panel Discussion

SESSION IX: Future Perspectives | Chairs: Emerson Perin, MD, PhD and Francisco Fernandez-Aviles, MD, PhD

12:00          Automation in Regenerative Medicine | Camila Hochman-Mendez, PhD

12:10           Futuristic Applications in Bio-Electrophysiology | Mehdi Razavi, MD

12:20 pm    Adjourn | Emerson Perin, MD, PhD and Francisco Fernandez-Aviles, MD, PhD

CME Learning Objectives & Credit Designtation

Target Audience

Our audience for this continuing medical education activity will include physicians, and researchers, also to include fellows, residents, physician assistants, nurses / nurse practitioners and medical students with an interest in cardiovascular regenerative medicine.

Educational Objectives

At the conclusion of this symposium, participants should be able to –

  • Achieve a comprehensive understanding of the latest development in cell and gene therapy.
  • Explain the mechanisms of action that have been proposed and discovered.
  • Discuss how to proceed and what to expect of devices and techniques in the future of therapy delivery.
  • Examine patient selection in novel cardiac regenerative medicine trials and subsequent therapies if they are approved.

Accreditation

The Texas Heart Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

The Texas Heart Institute designates this live activity for a maximum of 11.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Registration Fees

Register

The Texas Heart Institute and symposium program directors would like to invite its Professional Staff to attend the symposium at no cost.

When registering, please choose the payment option “Check” for waived fee.


Physician
$300.00

Industry
$300.00

Non-Physician
$100.00

Fellow/Resident
$100.00

Nurse/Nurse Practitioner
$100.00

Medical Student
$25.00


Refund & Cancellation Policy
The Texas Heart Institute Office of CME must receive written notification of a refund request no later than Friday, April 28, 2023. A $25.00 processing fee will be assessed for each cancellation.

Refunds cannot be made for those who register but do not attend the scheduled activities (both live and virtually).

Refunds will not be provided for cancellations made within 48 hours of the symposium.

The Texas Heart Institute reserves the right to cancel this activity if registration is deemed insufficient.

Travel and Lodging

Meeting Location

The symposium is held in the The Texas Heart Institute – The Denton A. Cooley Building located within the Texas Medical Center at 6770 Bertner Avenue, Houston, Texas 77030.

Entrance to the Denton A. Cooley Building is only through the Baylor St. Luke’s Medical Center Bates Street lobby (6720 Bertner Ave.).

The meeting will be held in The Denton A. Cooley auditorium located on the lower level of the Cooley Building which is accessible by the Green Elevators.

Lodging

There are several hotels in the Texas Medical Center within walking distance or short taxi.

Marriott Medical Center  (Group Rate)
6580 Fannin Street
Houston, TX 77030
Phone: 713-796-0080

Hilton Houston Plaza
6633 Travis Street
Houston, TX 77030
Phone: 713-313-4000

Wyndham Hotel & Suites
Houston Medical Center
6800 S. Main Street
Houston TX 77030
Phone: 713-528-7744

Hotel ZAZA
5701 Main Street
Houston, TX 77005
Phone: 713-526-1991

Ground Transportation 

Taxi service to the Texas Medical Center (TMC) hotels from Hobby Airport averages $35 one way. Taxi service from Bush Intercontinental Airport averages $50 one way. Uber & Lyft provide service in Houston. The drive to the TMC is approximately 30 minutes from Hobby Airport and approximately 45 minutes from Bush Intercontinental Airport. Rental car services are also available at both airports.

Parking

Parking for the event is available in Garage 2 located off Holcombe and Bertner for a fee of $13. You may also valet for $14 at the front of Baylor St. Luke’s Medical Center located at 6720 Bertner Avenue.

More information on parking and directions for the Texas Medical Center is available online at www.tmc.edu.

Discounted Hotel Room Rate

Make Reservations Here:

Complimentary Room Block for Cardiovascular Regenerative Medicine Symposium

For further information, please contact:
Don Battle
don.battle@ihg.com

Discover Houston: Home of the Largest Medical Center in the World

Since our founding by Dr. Denton A. Cooley in 1962, Texas Heart Institute has remained dedicated to improving the standard of care through education and research. Located in the heart of the largest medical complex in the world— in one of the largest and most diverse cities in the United States— our trainees gain unparalleled experience through sophisticated local, national, and global training networks.

“It’s the largest collection of doctors on the planet.”

Dr. Billy Cohn

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Discover Houston: The Museum District

Next door to the Texas Medical Center is the Houston Museum District with 19 museums including one of the largest museums in the US with a permanent collection that spans more than 6,000 years of history and includes approximately 64,000 works from six continents.

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Discover Houston: Local Eateries, Attractions, and Hotels

Eateries

III BY WOLFGANG PUCK
6550 Bertner Ave 6th Floor, Houston, TX 77030

III STREET EATS
Follow on social media for updates to menu, route, and schedule.

Waterside Food Hall
6550 Bertner Ave, 1st Floor, Houston, TX 77030


Attractions

Houston Museum of Natural Science
5555 Hermann Park Dr, Houston, TX 77030

Hermann Park
6001 Fannin St, Houston, TX 77030

Houston Zoo
6200 Hermann Park Dr, Houston, TX 77030

Theater District
Downtown Houston, TX


Hotels

Blossom Hotel Houston
7118 Bertner Ave, Houston, TX 77030

InterContinental Houston, an IHG Hotel
6750 Main St, Houston, TX 77030

Houston Marriott Medical Center/Museum District
6580 Fannin St, Houston, TX 77030