William E. Cohn, MD, PhD (H)

Dr. Cohn is the Chief Medical Officer of BiVACOR Inc. and the Executive Director of Medical Device Labs at the Texas Medical Center. He is also a tenured professor of surgery at Baylor College of Medicine and an adjunct professor of Bioengineering at Rice University and the University of Houston. Prior to joining BiVACOR Inc., he served as a Vice President at Johnson & Johnson MedTech, Executive Director for the Johnson & Johnson Center of Device Innovation at TMC, and Director of the renowned Cullen Cardiovascular Research Laboratory at The Texas Heart Institute.

Dr. Cohn has been deeply involved in developing the continuous-flow, totally implantable, artificial heart. In 2011, Dr. Cohn and Dr. O. H. Frazier successfully implanted the first pulseless total heart replacement device in a human patient. The device had been developed at The Texas Heart Institute.

Dr. Cohn has published extensively and has 124 granted US patents for his medical device innovations that have been foundational for nine venture-backed startups.

See Publications

Texas Heart Institute Positions

  • Teaching Staff, Cardiac Transplantation, Heart Failure and Assist Device Fellowships
  • Teaching Staff, Thoracic Surgery Residency

Interests

Education

  • Undergraduate:

    Oberlin College

  • Medical School:

    Baylor College of Medicine

  • Internship:

    Baylor College of Medicine

  • Residency:

    Baylor College of Medicine

  • Fellowships:

    Beth Israel Hospital, Harvard Medical School

Academic & Clinical Affiliations

Honors, Awards and Memberships

Publications

4862227 K336I6XW 1 alternatives-to-animal-experimentation 10 date desc Cohn 1868 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226JIFNVD6%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Steinmetz%20and%20Coselli%22%2C%22parsedDate%22%3A%222022-05-17%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSteinmetz%2C%20L.%20M.%20and%20Coselli%2C%20J.%20S.%20%282022%29.%20Endovascular%20repair%20in%20patients%20with%20Marfan%20syndrome%3A%20concerns%20amid%20controversy.%20%26lt%3Bi%26gt%3BAnn%20Vasc%20Surg%26lt%3B%5C%2Fi%26gt%3B%2C%20S0890-5096%2822%2900236%26%23x2013%3B9.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.avsg.2022.04.049%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.avsg.2022.04.049%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Endovascular%20repair%20in%20patients%20with%20Marfan%20syndrome%3A%20concerns%20amid%20controversy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leah%20M.%22%2C%22lastName%22%3A%22Steinmetz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20S.%22%2C%22lastName%22%3A%22Coselli%22%7D%5D%2C%22abstractNote%22%3A%22Endovascular%20aortic%20repair%20is%20widely%20used%20to%20treat%20patients%20with%20degenerative%20aneurysms%20or%20aortic%20dissection%20within%20the%20distal%20aorta.%20Thoracic%20endovascular%20aortic%20repair%20%28TEVAR%29%20is%20generally%20associated%20with%20fewer%20short-term%20complications%20than%20open%20surgical%20repair%2C%20which%20is%20particularly%20important%20for%20older%20patients%20with%20significant%20comorbid%20conditions.%20However%2C%20for%20patients%20with%20Marfan%20syndrome%2C%20a%20heritable%20thoracic%20aortic%20disease%20associated%20with%20aortic%20dilatation%2C%20dissection%2C%20and%20rupture%2C%20the%20utility%20of%20endovascular%20aortic%20repair%20remains%20questionable.%20Marfan%20patients%20have%20friable%20aortic%20tissue%20and%20are%20typically%20treated%20at%20a%20relatively%20young%20age%20with%20few%20comorbidities%3B%20they%20therefore%20have%20less%20operative%20risk%20and%20need%20a%20durable%20solution.%20Furthermore%2C%20those%20who%20need%20distal%20aortic%20repair%20tend%20to%20have%20chronic%20aortic%20dissection.%20Although%20TEVAR%20is%20generally%20superior%20to%20open%20surgery%20with%20regard%20to%20short-term%20complications%2C%20it%20is%20less%20durable%2C%20and%20TEVAR%20reintervention%20rates%20are%20highest%20in%20patients%20with%20chronic%20aortic%20dissection.%20Thus%2C%20Marfan%20patients%20seeking%20definitive%20aortic%20repair%20are%20often%20better%20served%20by%20open%20repair.%20Nonetheless%2C%20TEVAR%20may%20be%20useful%20in%20patients%20with%20Marfan%20syndrome%20as%20a%20bridge%20to%20open%20repair%20or%20as%20treatment%20for%20late%20complications%20of%20previous%20open%20repair.%22%2C%22date%22%3A%22May%2017%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.avsg.2022.04.049%22%2C%22ISSN%22%3A%221615-5947%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22BJSZ96GT%22%2C%22K336I6XW%22%2C%22ZSY78DJL%22%5D%2C%22dateModified%22%3A%222022-07-06T19%3A01%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22C3EMD3JM%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bieritz%20et%20al.%22%2C%22parsedDate%22%3A%222021-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBieritz%2C%20S.%20A.%2C%20Alex%20Smith%2C%20P.%2C%20Wang%2C%20Y.%20et%20al.%20%282021%29.%20Applicability%20of%20narrow%20groove%20theory%20in%20designing%20washout%20features%20for%20rotary%20blood%20pumps.%20%26lt%3Bi%26gt%3BAnnu%20Int%20Conf%20IEEE%20Eng%20Med%20Biol%20Soc%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B2021%26lt%3B%5C%2Fi%26gt%3B%2C%205419%26%23x2013%3B5424.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FEMBC46164.2021.9630426%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FEMBC46164.2021.9630426%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Applicability%20of%20narrow%20groove%20theory%20in%20designing%20washout%20features%20for%20rotary%20blood%20pumps%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shelby%20A.%22%2C%22lastName%22%3A%22Bieritz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Alex%20Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yaxin%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jane%22%2C%22lastName%22%3A%22Grande-Allen%22%7D%5D%2C%22abstractNote%22%3A%22High%20and%20low%20shear%20regions%20in%20rotary%20blood%20pumps%20require%20sufficient%20washout%20flow%20to%20minimize%20blood%20residence%20time%2C%20thereby%20preventing%20hemolysis%20or%20regions%20of%20stasis%20that%20can%20lead%20to%20pump%20thrombosis.%20Spiral%20groove%20bearings%20%28SGBs%29%20both%20enhance%20pump%20washout%20and%20reduce%20erythrocyte%20exposure%20to%20high%20shear.%20Narrow%20groove%20theory%20%28NGT%29%20has%20been%20used%20as%20an%20analytical%20tool%20to%20estimate%20the%20flow%20performance%20of%20a%20flat%20SGB%20during%20the%20design%20stage.%20However%2C%20NGT%20cannot%20accurately%20predict%20the%20performance%20of%20a%20conical%20SGB.%20In%20this%20study%2C%20we%20formulated%20an%20analytical%20model%20from%20the%20established%20NGT%20by%20adding%20an%20inertia%20correction%20term%20to%20incorporate%20variations%20in%20centrifugal%20force%2C%20which%20improved%20washout%20prediction%20in%20a%20conical%20SGB.%20The%20modified%20NGT%20model%20was%20then%20validated%20by%20comparison%20with%20experimental%20results.%20The%20results%20show%20that%20the%20modified%20NFT%20analytical%20model%20can%20reasonably%20predict%20washout%20rate%20when%20the%20spiral%20groove%20geometry%20favors%20creep%20flow%20conditions.%20The%20conical%20half%20angle%20of%20the%20SGB%20had%20the%20most%20significant%20impact%20on%20washout%2C%20with%20a%20decrease%20in%20half%20angle%20leading%20to%20large%20increases%20in%20wash-out%20flow.%20Small%20half%20angles%20also%20maintained%20viscous%20pumping%20at%20larger%20Reynolds%20numbers.%20In%20summary%2C%20the%20modified%20NGT%20can%20be%20a%20useful%20tool%20for%20designing%20conical%20SGBs%20for%20rotary%20blood%20pump%20washout%20within%20the%20creep%20flow%20regime.%22%2C%22date%22%3A%22Nov%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1109%5C%2FEMBC46164.2021.9630426%22%2C%22ISSN%22%3A%222694-0604%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22K336I6XW%22%2C%224IAB3NJ4%22%2C%22MBJXYIKW%22%2C%22AUPQENLZ%22%5D%2C%22dateModified%22%3A%222022-01-07T20%3A06%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22FW5Z2UTH%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Letsou%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLetsou%2C%20G.%20V.%2C%20Baldwin%2C%20A.%20C.%20W.%2C%20Civitello%2C%20A.%20B.%20et%20al.%20%282021%29.%20Continuous-flow%20left%20ventricular%20assist%20device%20explantation%20after%20more%20than%205%20years%20of%20circulatory%20support%20and%20ventricular%20reconditioning.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B48%26lt%3B%5C%2Fi%26gt%3B%2C%20e207266.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-20-7266%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-20-7266%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Continuous-flow%20left%20ventricular%20assist%20device%20explantation%20after%20more%20than%205%20years%20of%20circulatory%20support%20and%20ventricular%20reconditioning%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20V.%22%2C%22lastName%22%3A%22Letsou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20C.%20W.%22%2C%22lastName%22%3A%22Baldwin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20B.%22%2C%22lastName%22%3A%22Civitello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20H.%22%2C%22lastName%22%3A%22Frazier%22%7D%5D%2C%22abstractNote%22%3A%22Continuous-flow%20left%20ventricular%20assist%20devices%20have%20proved%20to%20be%20effective%2C%20durable%2C%20life-saving%20tools%20in%20patients%20with%20end-stage%20heart%20failure.%20However%2C%20because%20of%20the%20risks%20associated%20with%20mechanical%20circulatory%20support%20%28including%20stroke%2C%20infection%2C%20gastrointestinal%20bleeding%2C%20and%20device%20malfunction%29%2C%20the%20optimal%20goal%20of%20device%20therapy%20is%20myocardial%20recovery%20and%20device%20removal.%20Ventricular%20reconditioning%20and%20pump%20explantation%20after%20continuous-flow%20support%20have%20been%20reported%3B%20however%2C%20little%20is%20known%20about%20variables%20that%20govern%20the%20pace%20and%20degree%20of%20myocardial%20response%20in%20patients%20who%20experience%20such%20recovery.%20We%20describe%20our%20long-term%20pump-weaning%20strategy%20for%20a%2025-year-old%20man%20who%20had%20a%20continuous-flow%20device%20implanted%20and%20then%20needed%20more%20than%205%20years%20of%20support%20from%20it%20before%20developing%20cardiac%20reserve%20sufficient%20to%20enable%20pump%20explantation.%20To%20our%20knowledge%2C%20this%20is%20the%20longest%20period%20of%20uninterrupted%20continuous-flow%20device%20support%20to%20end%20in%20successful%20pump%20deactivation%20and%20a%20return%20to%20medical%20therapy.%20This%20case%20highlights%20the%20importance%20of%20actively%20and%20persistently%20pursuing%20a%20device-weaning%20strategy%20in%20all%20patients%20who%20need%20left%20ventricular%20assist%20device%20therapy.%22%2C%22date%22%3A%22Jun%2010%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-20-7266%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SE7HDD49%22%2C%229FBUJBMU%22%2C%22K336I6XW%22%2C%22YZAQAZIS%22%5D%2C%22dateModified%22%3A%222021-11-03T18%3A59%3A20Z%22%7D%7D%2C%7B%22key%22%3A%228JQS6ZLY%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Baldwin%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBaldwin%2C%20A.%20C.%2C%20Gemmato%2C%20C.%20J.%2C%20%26lt%3Bstrong%26gt%3BCohn%26lt%3B%5C%2Fstrong%26gt%3B%2C%20W.%20E.%20et%20al.%20%282021%29.%20Feasibility%20of%20long-term%20continuous%20flow%20total%20heart%20replacement%20in%20calves.%20%26lt%3Bi%26gt%3BInt%20J%20Artif%20Organs%26lt%3B%5C%2Fi%26gt%3B%2C%20391398820987851.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F0391398820987851%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F0391398820987851%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Feasibility%20of%20long-term%20continuous%20flow%20total%20heart%20replacement%20in%20calves%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20Cw%22%2C%22lastName%22%3A%22Baldwin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Courtney%20J.%22%2C%22lastName%22%3A%22Gemmato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20H.%22%2C%22lastName%22%3A%22Frazier%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Implementation%20of%20continuous%20flow%20%28CF%29%20technology%20in%20modern%20ventricular%20assist%20devices%20%28VAD%29%20has%20afforded%20a%20wealth%20of%20engineering%20and%20design%20advantages%20in%20the%20development%20of%20a%20total%20artificial%20heart%20%28TAH%29.%20However%2C%20clinical%20application%20of%20CF%20has%20created%20a%20unique%20physiologic%20state%2C%20the%20consequences%20of%20which%20remain%20largely%20unknown.%20We%20sought%20to%20evaluate%20clinical%20and%20biochemical%20markers%20of%20end-organ%20function%20in%20calves%20supported%20with%20biventricular%20CF%20VADs%20for%20more%20than%2030%5Cu2009days.%5CnMETHODS%3A%20Eight%20calves%20survived%20longer%20than%2030%5Cu2009days%20following%20biventriculectomy%20and%20implantation%20of%20dual%20CF%20VADs.%20Four%20types%20of%20CF%20pumps%20were%20utilized%20for%20the%20study.%20Serial%20hematologic%20and%20biochemical%20profiles%20were%20drawn%20as%20markers%20for%20end-organ%20function%2C%20and%20hemodynamic%20data-including%20pump%20flows%20and%20intravascular%20pressures-were%20continuously%20monitored.%5CnRESULTS%3A%20The%20eight%20calves%20survived%20an%20average%20of%2058.8%5Cu2009days%20%28range%2030-92%5Cu2009days%29.%20Two%20of%20the%20calves%20were%20electively%20terminated%20at%20the%20conclusion%20of%20the%20study%20period%2C%20while%20the%20remaining%20animals%20were%20euthanized%20as%20a%20result%20of%20respiratory%20distress%20%28n%5Cu2009%3D%5Cu20092%29%20or%20impaired%20pump%20flows%20%28n%5Cu2009%3D%5Cu20094%29.%20In%20each%20case%2C%20serial%20biochemical%20and%20hematologic%20values%20were%20suggestive%20of%20preserved%20end-organ%20function.%20Six%20animals%20successfully%20participated%20in%20treadmill%20exercise%20evaluations.%20No%20evidence%20of%20end-organ%20damage%20was%20encountered%20upon%20necropsy%20or%20histologic%20tissue%20analysis.%5CnCONCLUSION%3A%20Biventricular%20CF%20VAD%20implantation%20permits%20a%20viable%20bovine%20CFTAH%20model%20capable%20of%20demonstrating%20long-term%20survival.%20After%2030%5Cu2009days%20of%20completely%20nonpulsatile%20flow%2C%20cumulative%20hemodynamic%2C%20clinical%2C%20biochemical%2C%20and%20histological%20analyses%20were%20consistent%20with%20preserved%20end-organ%20function%2C%20suggesting%20previously%20unreported%20long-term%20feasibility%20of%20a%20CFTAH%20design.%22%2C%22date%22%3A%22Jan%2011%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1177%5C%2F0391398820987851%22%2C%22ISSN%22%3A%221724-6040%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SE7HDD49%22%2C%22K336I6XW%22%5D%2C%22dateModified%22%3A%222021-07-20T19%3A38%3A40Z%22%7D%7D%2C%7B%22key%22%3A%222LMAI7TR%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kamat%20and%20Cohn%22%2C%22parsedDate%22%3A%222021-01-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKamat%2C%20I.%20and%20%26lt%3Bstrong%26gt%3BCohn%26lt%3B%5C%2Fstrong%26gt%3B%2C%20W.%20E.%20%282021%29.%20Pericardial%20access%20through%20the%20right%20atrium%20in%20a%20porcine%20model.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B48%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-20-7244%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-20-7244%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pericardial%20access%20through%20the%20right%20atrium%20in%20a%20porcine%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ishan%22%2C%22lastName%22%3A%22Kamat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%5D%2C%22abstractNote%22%3A%22As%20procedures%20such%20as%20epicardial%20ventricular%20ablation%20and%20left%20atrial%20appendage%20occlusion%20become%20more%20commonplace%2C%20the%20need%20grows%20for%20safer%20techniques%20to%20access%20the%20physiologic%20pericardial%20space.%20Because%20this%20space%20contains%20minimal%20fluid%20for%20lubrication%2C%20prevailing%20methods%20of%20pericardial%20access%20pose%20considerable%20periprocedural%20risk%20to%20cardiac%20structures.%20Therefore%2C%20we%20devised%20a%20novel%20method%20of%20pericardial%20access%20in%20which%20carbon%20dioxide%20%28CO2%29%20is%20insufflated%20through%20a%20right%20atrial%20puncture%20under%20fluoroscopic%20guidance%2C%20enabling%20clear%20visualization%20of%20the%20cardiac%20silhouette%20separating%20from%20the%20chest%20wall.%20We%20performed%20the%20procedure%20in%208%20Landrace%20pigs%2C%20after%20which%20transthoracic%20percutaneous%20pericardial%20access%20was%20obtained%20by%20conventional%20means.%20All%20of%20the%20animals%20remained%20hemodynamically%20stable%20during%20the%20procedure%2C%20and%20none%20showed%20evidence%20of%20epicardial%20or%20coronary%20injury.%20The%20protective%20layer%20of%20CO2%20in%20the%20pericardial%20space%20anterior%20to%20the%20heart%20facilitated%20percutaneous%20access%20in%20our%20porcine%20model%2C%20and%20the%20absence%20of%20complications%20supports%20the%20potential%20safety%20of%20this%20method.%22%2C%22date%22%3A%22Jan%202%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-20-7244%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22K336I6XW%22%5D%2C%22dateModified%22%3A%222021-05-06T18%3A54%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22HAX2W9UU%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schutz%20et%20al.%22%2C%22parsedDate%22%3A%222020-08-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSchutz%2C%20A.%2C%20Mattar%2C%20A.%2C%20Loor%2C%20G.%20et%20al.%20%282020%29.%20Simple%20felt-plug%20closure%20technique%20for%20minimally%20invasive%20removal%20of%20a%20centrifugal-flow%20left%20ventricular%20assist%20device.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B47%26lt%3B%5C%2Fi%26gt%3B%2C%20322%26%23x2013%3B324.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-19-7097%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-19-7097%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Simple%20felt-plug%20closure%20technique%20for%20minimally%20invasive%20removal%20of%20a%20centrifugal-flow%20left%20ventricular%20assist%20device%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Schutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aladdein%22%2C%22lastName%22%3A%22Mattar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Shafii%22%7D%5D%2C%22abstractNote%22%3A%22As%20the%20indications%20for%20implanting%20left%20ventricular%20assist%20devices%20have%20expanded%2C%20some%20patients%20are%20qualifying%20for%20device%20removal%20after%20myocardial%20recovery.%20Whereas%20explantation%20has%20been%20described%20for%20previous%20generations%20of%20devices%2C%20no%20standard%20procedures%20have%20been%20developed.%20Removal%20of%20centrifugal-flow%20devices%20has%20created%20the%20need%20for%20a%20plug%20to%20seal%20the%20apical%20ventriculotomy%20after%20pump%20removal.%20However%2C%20no%20commercially%20available%20products%20are%20available%20in%20the%20United%20States.%20We%20used%20a%20novel%20technique%20to%20fashion%20a%20plug%20from%20Teflon%20felt%20and%20a%20Dacron%20graft%20to%20enable%20minimally%20invasive%20explantation%20of%20a%20current-generation%20centrifugal-flow%20device%20in%20a%2033-year-old%20woman.%22%2C%22date%22%3A%22Aug%201%2C%202020%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-19-7097%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22K336I6XW%22%2C%22GNSKWJNU%22%2C%22ZMAN8MMI%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A19%3A49Z%22%7D%7D%2C%7B%22key%22%3A%226CPQ5FS4%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nestler%20et%20al.%22%2C%22parsedDate%22%3A%222020-01-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNestler%2C%20F.%2C%20Timms%2C%20D.%20L.%2C%20Stevens%2C%20M.%20et%20al.%20%282020%29.%20Investigation%20of%20the%20inherent%20left-right%20flow%20balancing%20of%20rotary%20total%20artificial%20hearts%20by%20means%20of%20a%20resistance%20box.%20%26lt%3Bi%26gt%3BArtif%20Organs%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faor.13631%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faor.13631%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigation%20of%20the%20inherent%20left-right%20flow%20balancing%20of%20rotary%20total%20artificial%20hearts%20by%20means%20of%20a%20resistance%20box%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Nestler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20L.%22%2C%22lastName%22%3A%22Timms%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Stevens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20P.%22%2C%22lastName%22%3A%22Bradley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20J.%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Kleinheyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nigel%22%2C%22lastName%22%3A%22Lovell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20H.%22%2C%22lastName%22%3A%22Frazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%5D%2C%22abstractNote%22%3A%22With%20the%20incidence%20of%20end-stage%20heart%20failure%20steadily%20increasing%2C%20the%20need%20for%20a%20practical%20total%20artificial%20heart%20%28TAH%29%20has%20never%20been%20greater.%20Continuous%20flow%20TAHs%20%28CFTAH%29%20are%20being%20developed%20using%20rotary%20blood%20pumps%20%28RBPs%29%2C%20leveraging%20their%20small%20size%2C%20mechanical%20simplicity%2C%20and%20excellent%20durability.%20To%20completely%20replace%20the%20heart%20with%20currently%20available%20RBPs%2C%20two%20are%20required%3B%20one%20for%20providing%20pulmonary%20flow%20and%20one%20for%20providing%20systemic%20flow.%20To%20prevent%20hazardous%20states%2C%20it%20is%20essential%20to%20maintain%20balance%20between%20the%20pulmonary%20and%20systemic%20circulation%20at%20a%20wide%20variety%20of%20physiologic%20states.%20In%20this%20study%2C%20we%20investigated%20factors%20determining%20a%20CFTAH%26%23039%3Bs%20inherent%20ability%20to%20balance%20systemic%20and%20pulmonary%20flow%20passively%2C%20without%20active%20management%20of%20pump%20rotational%20speed.%20Four%20different%20RBPs%20%28ReliantHeart%20HA5%2C%20Thoratec%20HMII%2C%20HeartWare%20HVAD%2C%20and%20Ventracor%20VentrAssist%29%20were%20used%20in%20various%20combinations%20to%20construct%20CFTAHs.%20Each%20CFTAH%26%23039%3Bs%20ability%20to%20autonomously%20maintain%20pressures%20and%20flows%20within%20defined%20ranges%20was%20evaluated%20in%20a%20hybrid%20mock%20loop%20as%20systemic%20and%20pulmonary%20vascular%20resistance%20%28PVR%29%20were%20changed.%20The%20resistance%20box%2C%20a%20method%20to%20quantify%20the%20range%20of%20vascular%20resistances%20that%20can%20be%20safely%20supported%20by%20a%20CFTAH%2C%20was%20used%20to%20compare%20different%20CFTAH%20configurations%20in%20an%20efficient%20and%20predictive%20way.%20To%20reduce%20the%20need%20for%20future%20in%20vitro%20tests%20and%20to%20aid%20in%20their%20analysis%2C%20a%20novel%20analytical%20evaluation%20to%20predict%20the%20resistance%20box%20of%20various%20CFTAH%20configurations%20was%20also%20performed.%20None%20of%20the%20investigated%20CFTAH%20configurations%20fully%20satisfied%20the%20predefined%20benchmarks%20for%20inherent%20flow%20balancing%2C%20with%20the%20VentrAssist%20%28left%29%20and%20HeartAssist%205%20%28right%29%20offering%20the%20best%20combination.%20The%20extent%20to%20which%20each%20CFTAH%20was%20able%20to%20autonomously%20maintain%20balance%20was%20determined%20by%20the%20pressure%20sensitivity%20of%20each%20RPB%3A%20the%20sensitivity%20of%20outflow%20to%20changes%20in%20the%20pressure%20head.%20The%20analytical%20model%20showed%20that%20by%20matching%20left%20and%20right%20pressure%20sensitivity%20the%20inherent%20balancing%20performance%20can%20be%20improved.%20These%20findings%20may%20ultimately%20lead%20to%20a%20reduced%20need%20for%20manual%20speed%20changes%20or%20active%20control%20systems.%22%2C%22date%22%3A%22Jan%2008%2C%202020%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Faor.13631%22%2C%22ISSN%22%3A%221525-1594%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SE7HDD49%22%2C%22K336I6XW%22%5D%2C%22dateModified%22%3A%222020-04-15T19%3A20%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22B7E6ANUI%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kurihara%20et%20al.%22%2C%22parsedDate%22%3A%222019-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKurihara%2C%20C.%2C%20%26lt%3Bstrong%26gt%3BCohn%26lt%3B%5C%2Fstrong%26gt%3B%2C%20W.%20E.%2C%20Kawabori%2C%20M.%20et%20al.%20%282019%29.%20Long-term%20continuous-flow%20left%20ventricular%20assist%20device%20support%20after%20left%20ventricular%20outflow%20tract%20closure.%20%26lt%3Bi%26gt%3BASAIO%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B65%26lt%3B%5C%2Fi%26gt%3B%2C%20558%26%23x2013%3B564.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMAT.0000000000000856%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMAT.0000000000000856%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Long-term%20continuous-flow%20left%20ventricular%20assist%20device%20support%20after%20left%20ventricular%20outflow%20tract%20closure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chitaru%22%2C%22lastName%22%3A%22Kurihara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masashi%22%2C%22lastName%22%3A%22Kawabori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tadahisa%22%2C%22lastName%22%3A%22Sugiura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20B.%22%2C%22lastName%22%3A%22Civitello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%20A.%22%2C%22lastName%22%3A%22Morgan%22%7D%5D%2C%22abstractNote%22%3A%22Aortic%20valve%20insufficiency%20can%20be%20addressed%20during%20continuous-flow%20left%20ventricular%20assist%20device%20%28CF-LVAD%29%20implantation%20by%20performing%20aortic%20valve%20repair%20or%20replacement%2C%20or%20patch%20closure%20of%20the%20left%20ventricular%20outflow%20tract%20%28LVOT%29.%20However%2C%20few%20studies%20have%20examined%20the%20safety%20of%20long-term%20CF-LVAD%20support%20after%20LVOT%20closure.%20From%20November%202003%20through%20March%202016%2C%2016%20patients%20with%20advanced%20chronic%20heart%20failure%20underwent%20CF-LVAD%20implantation%20and%20concomitant%20LVOT%20closure%20for%20severe%20aortic%20insufficiency.%20We%20compared%20their%20long-term%20outcomes%20with%20those%20of%20510%20CF-LVAD%20recipients%20without%20concomitant%20LVOT%20closure.%20Total%20support%20time%20was%2026.1%20patient-years%20in%20the%20LVOT-closure%20group%20and%20938.6%20patient-years%20in%20the%20CF-LVAD-only%20group.%20Survival%20at%2030%20days%2C%206%20months%2C%201%20year%2C%20and%202%20years%20was%20similar%20for%20CF-LVAD-only%20patients%20%2890.4%25%2C%2080.6%25%2C%2074.3%25%2C%2067.5%25%29%20and%20LVOT-closure%20patients%20%2881.3%25%2C%2081.3%25%2C%2075.0%25%2C%2068.8%25%3B%20p%20%3D%200.59%29.%20There%20were%20no%20deaths%20related%20to%20LVOT%20closure.%20The%20event%20rate%20per%20patient-year%20for%20neurologic%20dysfunction%20%28ND%29%20was%200.23%20in%20the%20LVOT-closure%20group%20%286%20ND%20events%29%20and%200.20%20in%20the%20CF-LVAD-only%20group%20%28136%20ND%20events%3B%20p%20%3D%200.97%29.%20We%20conclude%20that%20for%20select%20patients%20with%20aortic%20insufficiency%20who%20are%20undergoing%20CF-LVAD%20implantation%2C%20LVOT%20closure%20produces%20acceptable%20outcomes%20and%2C%20therefore%2C%20is%20a%20viable%20option.%22%2C%22date%22%3A%22Aug%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FMAT.0000000000000856%22%2C%22ISSN%22%3A%221538-943X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229FBUJBMU%22%2C%22K336I6XW%22%5D%2C%22dateModified%22%3A%222019-08-09T20%3A17%3A38Z%22%7D%7D%2C%7B%22key%22%3A%225KEZR6S2%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Letsou%20et%20al.%22%2C%22parsedDate%22%3A%222019-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLetsou%2C%20G.%20V.%2C%20Anand%2C%20J.%2C%20Ogburn%2C%20E.%20et%20al.%20%282019%29.%20Low%20incidence%20of%20pump-related%20infections%20in%20Jarvik%202000%20Ventricular%20Assist%20Device%20recipients%20with%20a%20subcostal%20driveline%20exit%20site.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B46%26lt%3B%5C%2Fi%26gt%3B%2C%20179%26%23x2013%3B182.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-15-5708%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-15-5708%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Low%20incidence%20of%20pump-related%20infections%20in%20Jarvik%202000%20Ventricular%20Assist%20Device%20recipients%20with%20a%20subcostal%20driveline%20exit%20site%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%20V.%22%2C%22lastName%22%3A%22Letsou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jatin%22%2C%22lastName%22%3A%22Anand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erinn%22%2C%22lastName%22%3A%22Ogburn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rohan%20M.%22%2C%22lastName%22%3A%22Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%20V.%22%2C%22lastName%22%3A%22Ganapathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20H.%22%2C%22lastName%22%3A%22Frazier%22%7D%5D%2C%22abstractNote%22%3A%22Driveline%20infection%20has%20been%20a%20persistent%20problem%20with%20mechanical%20cardiac%20assist%20devices.%20The%20reported%20incidence%20of%20infection%20has%20been%20low%20in%20patients%20who%20receive%20a%20Jarvik%202000%20continuous-flow%20left%20ventricular%20assist%20device%20when%20a%20skull-pedestal%20driveline%20exit%20site%20is%20used.%20We%20evaluated%20whether%20this%20is%20also%20true%20when%20a%20subcostal%20driveline%20exit%20site%20is%20used.%20We%20reviewed%20baseline%20demographic%20variables%2C%20postimplantation%20vital%20signs%2C%20laboratory%20values%2C%20and%20culture%20results%20in%20patients%20who%20underwent%20Jarvik%202000%20implantation%20at%20our%20center%20from%20April%202000%20through%20October%202009%2C%20including%20follow-up%20through%20June%202014.%20All%20patients%20had%20a%20subcostal%20driveline%20exit%20site.%20We%20defined%20device-related%20infection%20as%20a%20positive%20blood%20or%20wound%20culture%20associated%20with%20a%20medical%20or%20surgical%20device%20intervention.%20Event%20and%20time-to-event%20rates%20were%20calculated.%20Eighty-one%20patients%20received%2089%20Jarvik%202000%20devices%2C%20all%20as%20bridges%20to%20transplantation.%20The%20median%20support%20duration%20was%2069%20days%20%28interquartile%20range%2C%2027-153%20d%3B%20range%2C%202-2%2C249%20d%29.%20Five%20superficial%20driveline%20infections%20and%20one%20incision-site%20infection%20occurred%20%280.002%20events%20per%20patient-year%20of%20support%29.%20The%20median%20time%20from%20pump%20implantation%20to%20onset%20of%20driveline%20infection%20was%2030%20days%3B%20the%20incision-related%20infection%20occurred%20at%2044%20days.%20The%20Jarvik%202000%20has%20a%20low%20incidence%20of%20infection%20when%20implanted%20with%20use%20of%20a%20subcostal%20driveline%20exit%20site.%20The%20incidence%20of%20pump%20infections%20is%20particularly%20low.%20Using%20a%20subcostal%20driveline%20exit%20site%20may%20be%20as%20effective%20in%20preventing%20infections%20as%20using%20a%20skull-pedestal%20driveline%20exit%20site.%20We%20detail%20our%20findings%20in%20this%20report.%22%2C%22date%22%3A%22Jun%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-15-5708%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SE7HDD49%22%2C%22K336I6XW%22%2C%22YZAQAZIS%22%2C%22GNSKWJNU%22%2C%22FJXP7WZ4%22%5D%2C%22dateModified%22%3A%222019-12-09T21%3A31%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22ATRTFECA%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hord%20et%20al.%22%2C%22parsedDate%22%3A%222019-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHord%2C%20E.%20C.%2C%20Bolch%2C%20C.%20M.%2C%20Tuzun%2C%20E.%20et%20al.%20%282019%29.%20Evaluation%20of%20the%20CorInnova%20Heart%20Assist%20Device%20in%20an%20Acute%20Heart%20Failure%20Model.%20%26lt%3Bi%26gt%3BJ%20Cardiovasc%20Transl%20Res%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%20155%26%23x2013%3B163.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs12265-018-9854-5%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs12265-018-9854-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evaluation%20of%20the%20CorInnova%20Heart%20Assist%20Device%20in%20an%20Acute%20Heart%20Failure%20Model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erica%20C.%22%2C%22lastName%22%3A%22Hord%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%20M.%22%2C%22lastName%22%3A%22Bolch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Egemen%22%2C%22lastName%22%3A%22Tuzun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Cohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Boris%22%2C%22lastName%22%3A%22Leschinsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20C.%22%2C%22lastName%22%3A%22Criscione%22%7D%5D%2C%22abstractNote%22%3A%22While%20the%20number%20of%20patients%20supported%20with%20temporary%20cardiac%20assist%20is%20growing%2C%20the%20existing%20devices%20are%20limited%20by%20a%20multitude%20of%20complications%2C%20mostly%20related%20to%20contact%20with%20the%20blood.%20The%20CorInnova%20epicardial%20compressive%20heart%20assist%20device%20was%20tested%20in%20six%20sheep%20using%20an%20acute%20heart%20failure%20model.%20High%20esmolol%20dose%2C%20targeting%20a%2050%25%20reduction%20in%20CO%20from%20healthy%20baseline%2C%20resulted%20in%20a%20failure%20state%20with%20mean%20CO%201.9%5Cu00a0L%5C%2Fmin.%20Heart%20assist%20with%20the%20device%20during%20failure%20state%20resulted%20in%20an%20average%20absolute%20increase%20in%20CO%20of%201.0%5Cu00a0L%5C%2Fmin%2C%20along%20with%20a%20decline%20in%20ventricular%20work%20to%2067.5%25%20of%20the%20total%20LV%20SW.%20Combined%20with%20repeated%20success%20of%20minimally%20invasive%20device%20implant%2C%20the%20resulting%20increases%20in%20cardiac%20hemodynamics%20achieved%20while%20still%20unloading%20the%20heart%20demonstrate%20the%20potential%20of%20the%20CorInnova%20device%20for%20temporary%20heart%20assist.%22%2C%22date%22%3A%22Apr%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs12265-018-9854-5%22%2C%22ISSN%22%3A%221937-5395%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22K336I6XW%22%5D%2C%22dateModified%22%3A%222019-06-06T15%3A20%3A49Z%22%7D%7D%5D%7D
Steinmetz, L. M. and Coselli, J. S. (2022). Endovascular repair in patients with Marfan syndrome: concerns amid controversy. Ann Vasc Surg, S0890-5096(22)00236–9. https://doi.org/10.1016/j.avsg.2022.04.049.
Bieritz, S. A., Alex Smith, P., Wang, Y. et al. (2021). Applicability of narrow groove theory in designing washout features for rotary blood pumps. Annu Int Conf IEEE Eng Med Biol Soc 2021, 5419–5424. https://doi.org/10.1109/EMBC46164.2021.9630426.
Letsou, G. V., Baldwin, A. C. W., Civitello, A. B. et al. (2021). Continuous-flow left ventricular assist device explantation after more than 5 years of circulatory support and ventricular reconditioning. Tex Heart Inst J 48, e207266. https://doi.org/10.14503/THIJ-20-7266.
Baldwin, A. C., Gemmato, C. J., Cohn, W. E. et al. (2021). Feasibility of long-term continuous flow total heart replacement in calves. Int J Artif Organs, 391398820987851. https://doi.org/10.1177/0391398820987851.
Kamat, I. and Cohn, W. E. (2021). Pericardial access through the right atrium in a porcine model. Tex Heart Inst J 48. https://doi.org/10.14503/THIJ-20-7244.
Schutz, A., Mattar, A., Loor, G. et al. (2020). Simple felt-plug closure technique for minimally invasive removal of a centrifugal-flow left ventricular assist device. Tex Heart Inst J 47, 322–324. https://doi.org/10.14503/THIJ-19-7097.
Nestler, F., Timms, D. L., Stevens, M. et al. (2020). Investigation of the inherent left-right flow balancing of rotary total artificial hearts by means of a resistance box. Artif Organs. https://doi.org/10.1111/aor.13631.
Kurihara, C., Cohn, W. E., Kawabori, M. et al. (2019). Long-term continuous-flow left ventricular assist device support after left ventricular outflow tract closure. ASAIO J 65, 558–564. https://doi.org/10.1097/MAT.0000000000000856.
Letsou, G. V., Anand, J., Ogburn, E. et al. (2019). Low incidence of pump-related infections in Jarvik 2000 Ventricular Assist Device recipients with a subcostal driveline exit site. Tex Heart Inst J 46, 179–182. https://doi.org/10.14503/THIJ-15-5708.
Hord, E. C., Bolch, C. M., Tuzun, E. et al. (2019). Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model. J Cardiovasc Transl Res 12, 155–163. https://doi.org/10.1007/s12265-018-9854-5.

Recent News

See All

A Legacy of Invention: Dr. Billy Cohn and the Spirit of Innovation at The Texas Heart Institute

Some careers follow established paths. Others create entirely new ones. For decades, William E. Cohn, MD, known to colleagues and...

Read more

The Texas Heart Institute Hosts 2024 Rodeo Roundtable: Cardiogenic Shock

On Saturday, March 2, 2024, The Texas Heart Institute hosted THI Rodeo Roundtable 2024: Cardiogenic Shock, a discussion group chaired...

Read more

THI Continues to Play a Pivotal Role in the Latest Development in the Field of Artificial Heart Technology

The Texas Heart Institute partner, BiVACOR, gets additional support Total Artificial Heart program   With plans for an FDA-granted investigational...

Read more
PHP Code Snippets Powered By : XYZScripts.com