Xiao Li, PhD

Precise regulation of gene expression programs underlies homeostasis of various types of cardiac and immune cells in the human heart. Disruption of such intricate programs often imbalances the fibrotic and immune microenvironment in heart failure. My lab utilizes cutting-edge technologies including single-cell genomics and genome editing to explore novel mechanisms that control these programs. By understanding the diverse genomic and cellular responses to heart injury in individual patients, we aim to improve the prevention of heart failure and develop personalized treatments to enhance recovery.

See Publications

Texas Heart Institute Positions

Current Projects

  • Integration of large-scale single-cell transcriptomics and genomics data
  • Immune microenvironment that regulates cardiac function and the pathology of heart failure
  • Application of computational genomics and machine learning and in cardiac biology
  • Chromatin-associated RNA and chromatin organization in the heart


  • Cardiovascular biology
  • Molecular immunology
  • Functional genomics
  • Computational biology
  • Pediatric cardiomyopathy and graft dysfunction


  • Undergraduate:

    East China Normal University (Shanghai, China)

  • Graduate:

    University of Iowa (Iowa City, IA)

  • Postgraduate:

    Postdoctoral training, University of California, San Diego (La Jolla CA)