Todd R. Heallen, PhD

See Publications

Texas Heart Institute Positions

Assistant Research Investigator, Cardiomyocyte Renewal Laboratory

Interests

Cardiac Regeneration

Education

Undergraduate:

Texas A&M University
Postgraduate:

UTHSCH-GSBS
Fellowships:

Texas A&M IBT; Baylor College of Medicine

Academic & Clinical Affiliations

Baylor College of Medicine

Honors, Awards and Memberships

American Heart Association

Publications

4862227 QH7R47P9 1 alternatives-to-animal-experimentation 10 date desc Heallen 1932 https://www.texasheart.org/wp-content/plugins/zotpress/

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Liu, S., Tang, L., Zhao, X. et al. (2021). Yap promotes noncanonical Wnt signals from cardiomyocytes for heart regeneration. Circ Res 129, 782–797. https://doi.org/10.1161/CIRCRESAHA.121.318966.

Liu, S., Li, K., Wagner Florencio, L. et al. (2021). Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med 13, eabd6892. https://doi.org/10.1126/scitranslmed.abd6892.

Heallen, T. R., Kadow, Z. A., Wang, J. et al. (2020). Determinants of cardiac growth and size. Cold Spring Harb Perspect Biol 12. https://doi.org/10.1101/cshperspect.a037150.

Heallen, T. R., Kadow, Z. A., Kim, J. H. et al. (2019). Stimulating cardiogenesis as a treatment for heart failure. Circ Res 124, 1647–1657. https://doi.org/10.1161/CIRCRESAHA.118.313573.

Monroe, T. O., Hill, M. C., Morikawa, Y. et al. (2019). YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo. Dev Cell 48, 765-779.e7. https://doi.org/10.1016/j.devcel.2019.01.017.

Wang, J., Liu, S., Heallen, T. et al. (2018). The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol 15, 672–684. https://doi.org/10.1038/s41569-018-0063-3.

Heallen, T. R. and Martin, J. F. (2018). Heart repair via cardiomyocyte-secreted vesicles. Nat Biomed Eng 2, 271–272. https://doi.org/10.1038/s41551-018-0239-5.

Leach, J. P., Heallen, T., Zhang, M. et al. (2017). Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550, 260–264. https://doi.org/10.1038/nature24045.

Morikawa, Y., Heallen, T., Leach, J. et al. (2017). Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature 547, 227–231. https://doi.org/10.1038/nature22979.

Tao, G., Kahr, P. C., Morikawa, Y. et al. (2016). Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature 534, 119–123. https://doi.org/10.1038/nature17959.

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