Qian Xiang

Texas Heart Institute Positions

Publications

4862227 9T6HXJUI 1 alternatives-to-animal-experimentation 10 date desc Xiang 2172 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225FM49INS%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guan%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGuan%2C%20Y.-S.%2C%20Ershad%2C%20F.%2C%20Rao%2C%20Z.%20et%20al.%20%282022%29.%20Elastic%20electronics%20based%20on%20micromesh-structured%20rubbery%20semiconductor%20films.%20%26lt%3Bi%26gt%3BNat%20Electron%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41928-022-00874-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41928-022-00874-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Elastic%20electronics%20based%20on%20micromesh-structured%20rubbery%20semiconductor%20films%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying-Shi%22%2C%22lastName%22%3A%22Guan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faheem%22%2C%22lastName%22%3A%22Ershad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhoulyu%22%2C%22lastName%22%3A%22Rao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhifan%22%2C%22lastName%22%3A%22Ke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernesto%20Curty%22%2C%22lastName%22%3A%22da%20Costa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuntao%22%2C%22lastName%22%3A%22Lu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xu%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jianguo%22%2C%22lastName%22%3A%22Mei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Vanderslice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camila%22%2C%22lastName%22%3A%22Hochman-Mendez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cunjiang%22%2C%22lastName%22%3A%22Yu%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Nov%2028%202022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41928-022-00874-z%22%2C%22ISSN%22%3A%222520-1131%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41928-022-00874-z%22%2C%22collections%22%3A%5B%22BBMMGS3D%22%2C%22MJL5PY3A%22%2C%229T6HXJUI%22%2C%2235JIYMYN%22%2C%22QF52JASW%22%5D%2C%22dateModified%22%3A%222022-12-01T19%3A16%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22W3T5H5J2%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mendiola%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-17%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMendiola%2C%20E.%20A.%2C%20Neelakantan%2C%20S.%2C%20%26lt%3Bstrong%26gt%3BXiang%26lt%3B%5C%2Fstrong%26gt%3B%2C%20Q.%20et%20al.%20%282022%29.%20Contractile%20adaptation%20of%20the%20left%20ventricle%20post-myocardial%20infarction%3A%20predictions%20by%20rodent-specific%20computational%20modeling.%20%26lt%3Bi%26gt%3BAnn%20Biomed%20Eng%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10439-022-03102-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10439-022-03102-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Contractile%20adaptation%20of%20the%20left%20ventricle%20post-myocardial%20infarction%3A%20predictions%20by%20rodent-specific%20computational%20modeling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilio%20A.%22%2C%22lastName%22%3A%22Mendiola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunder%22%2C%22lastName%22%3A%22Neelakantan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samer%22%2C%22lastName%22%3A%22Merchant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ke%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%20W.%22%2C%22lastName%22%3A%22Hsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20A.%20F.%22%2C%22lastName%22%3A%22Dixon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Vanderslice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reza%22%2C%22lastName%22%3A%22Avazmohammadi%22%7D%5D%2C%22abstractNote%22%3A%22Myocardial%20infarction%20%28MI%29%20results%20in%20cardiac%20myocyte%20death%20and%20the%20formation%20of%20a%20fibrotic%20scar%20in%20the%20left%20ventricular%20free%20wall%20%28LVFW%29.%20Following%20an%20acute%20MI%2C%20LVFW%20remodeling%20takes%20place%20consisting%20of%20several%20alterations%20in%20the%20structure%20and%20properties%20of%20cellular%20and%20extracellular%20components%20with%20a%20heterogeneous%20pattern%20across%20the%20LVFW.%20The%20normal%20function%20of%20the%20heart%20is%20strongly%20influenced%20by%20the%20passive%20and%20active%20biomechanical%20behavior%20of%20the%20LVFW%2C%20and%20progressive%20myocardial%20structural%20remodeling%20can%20have%20a%20detrimental%20effect%20on%20both%20diastolic%20and%20systolic%20functions%20of%20the%20LV%20leading%20to%20heart%20failure.%20Despite%20important%20advances%20in%20understanding%20LVFW%20passive%20remodeling%20in%20the%20setting%20of%20MI%2C%20heterogeneous%20remodeling%20in%20the%20LVFW%20active%20properties%20and%20its%20relationship%20to%20organ-level%20LV%20function%20remain%20understudied.%20To%20address%20these%20gaps%2C%20we%20developed%20high-fidelity%20finite-element%20%28FE%29%20rodent%20computational%20cardiac%20models%20%28RCCMs%29%20of%20MI%20using%20extensive%20datasets%20from%20MI%20rat%20hearts%20representing%20the%20heart%20remodeling%20from%20one-week%20%281-wk%29%20to%20four-week%20%284-wk%29%20post-MI%20timepoints.%20The%20rat-specific%20models%20%28n%20%3D%202%20for%20each%20timepoint%29%20integrate%20detailed%20imaging%20data%20of%20the%20heart%20geometry%2C%20myocardial%20fiber%20architecture%2C%20and%20infarct%20zone%20determined%20using%20late%20gadolinium%20enhancement%20prior%20to%20terminal%20measurements.%20The%20computational%20models%20predicted%20a%20significantly%20higher%20level%20of%20active%20tension%20in%20remote%20myocardium%20in%20early%20post-MI%20hearts%20%281-wk%20post-MI%29%20followed%20by%20a%20return%20to%20near%20the%20control%20level%20in%20late-stage%20MI%20%283-%20and%204-wk%20post-MI%29.%20The%20late-stage%20MI%20rats%20showed%20smaller%20myofiber%20ranges%20in%20the%20remote%20region%20and%20in-silico%20experiments%20using%20RCCMs%20suggested%20that%20the%20smaller%20fiber%20helicity%20is%20consistent%20with%20lower%20contractile%20forces%20needed%20to%20meet%20the%20measured%20ejection%20fractions%20in%20late-stage%20MI.%20In%20contrast%2C%20in-silico%20experiments%20predicted%20that%20collagen%20fiber%20transmural%20orientation%20in%20the%20infarct%20region%20has%20little%20influence%20on%20organ-level%20function.%20In%20addition%2C%20our%20MI%20RCCMs%20indicated%20that%20reduced%20and%20potentially%20positive%20circumferential%20strains%20in%20the%20infarct%20region%20at%20end-systole%20can%20be%20used%20to%20infer%20information%20about%20the%20time-varying%20properties%20of%20the%20infarct%20region.%20The%20detailed%20description%20of%20regional%20passive%20and%20active%20remodeling%20patterns%20can%20complement%20and%20enhance%20the%20traditional%20measures%20of%20LV%20anatomy%20and%20function%20that%20often%20lead%20to%20a%20gross%20and%20limited%20assessment%20of%20cardiac%20performance.%20The%20translation%20and%20implementation%20of%20our%20model%20in%20patient-specific%20organ-level%20simulations%20offer%20to%20advance%20the%20investigation%20of%20individualized%20prognosis%20and%20intervention%20for%20MI.%22%2C%22date%22%3A%22Nov%2017%2C%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10439-022-03102-z%22%2C%22ISSN%22%3A%221573-9686%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22WGZKEVDQ%22%2C%22BBMMGS3D%22%2C%2242FKW3I4%22%2C%229T6HXJUI%22%2C%22TXW6RMW4%22%5D%2C%22dateModified%22%3A%222023-01-06T17%3A13%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22V95W4SUL%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Babaei%20et%20al.%22%2C%22parsedDate%22%3A%222022-03-31%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBabaei%2C%20H.%2C%20Mendiola%2C%20E.%20A.%2C%20Neelakantan%2C%20S.%20et%20al.%20%282022%29.%20A%20machine%20learning%20model%20to%20estimate%20myocardial%20stiffness%20from%20EDPVR.%20%26lt%3Bi%26gt%3BSci%20Rep%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%205433.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-022-09128-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-022-09128-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20machine%20learning%20model%20to%20estimate%20myocardial%20stiffness%20from%20EDPVR%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hamed%22%2C%22lastName%22%3A%22Babaei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilio%20A.%22%2C%22lastName%22%3A%22Mendiola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sunder%22%2C%22lastName%22%3A%22Neelakantan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Vang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20A.%20F.%22%2C%22lastName%22%3A%22Dixon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dipan%20J.%22%2C%22lastName%22%3A%22Shah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Vanderslice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaurav%22%2C%22lastName%22%3A%22Choudhary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reza%22%2C%22lastName%22%3A%22Avazmohammadi%22%7D%5D%2C%22abstractNote%22%3A%22In-vivo%20estimation%20of%20mechanical%20properties%20of%20the%20myocardium%20is%20essential%20for%20patient-specific%20diagnosis%20and%20prognosis%20of%20cardiac%20disease%20involving%20myocardial%20remodeling%2C%20including%20myocardial%20infarction%20and%20heart%20failure%20with%20preserved%20ejection%20fraction.%20Current%20approaches%20use%20time-consuming%20finite-element%20%28FE%29%20inverse%20methods%20that%20involve%20reconstructing%20and%20meshing%20the%20heart%20geometry%2C%20imposing%20measured%20loading%2C%20and%20conducting%20computationally%20expensive%20iterative%20FE%20simulations.%20In%20this%20paper%2C%20we%20propose%20a%20machine%20learning%20%28ML%29%20model%20that%20feasibly%20and%20accurately%20predicts%20passive%20myocardial%20properties%20directly%20from%20select%20geometric%2C%20architectural%2C%20and%20hemodynamic%20measures%2C%20thus%20bypassing%20exhaustive%20steps%20commonly%20required%20in%20cardiac%20FE%20inverse%20problems.%20Geometric%20and%20fiber-orientation%20features%20were%20chosen%20to%20be%20readily%20obtainable%20from%20standard%20cardiac%20imaging%20protocols.%20The%20end-diastolic%20pressure-volume%20relationship%20%28EDPVR%29%2C%20which%20can%20be%20obtained%20using%20a%20single-point%20pressure-volume%20measurement%2C%20was%20used%20as%20a%20hemodynamic%20%28loading%29%20feature.%20A%20comprehensive%20ML%20training%20dataset%20in%20the%20geometry-architecture-loading%20space%20was%20generated%2C%20including%20a%20wide%20variety%20of%20partially%20synthesized%20rodent%20heart%20geometry%20and%20myofiber%20helicity%20possibilities%2C%20and%20a%20broad%20range%20of%20EDPVRs%20obtained%20using%20forward%20FE%20simulations.%20Latin%20hypercube%20sampling%20was%20used%20to%20create%202500%20examples%20for%20training%2C%20validation%2C%20and%20testing.%20A%20multi-layer%20feed-forward%20neural%20network%20%28MFNN%29%20was%20used%20as%20a%20deep%20learning%20agent%20to%20train%20the%20ML%20model.%20The%20model%20showed%20excellent%20performance%20in%20predicting%20stiffness%20parameters%20%5BFormula%3A%20see%20text%5D%20and%20%5BFormula%3A%20see%20text%5D%20associated%20with%20fiber%20direction%20%28%5BFormula%3A%20see%20text%5D%20and%20%5BFormula%3A%20see%20text%5D%29.%20After%20conducting%20permutation%20feature%20importance%20analysis%2C%20the%20ML%20performance%20further%20improved%20for%20%5BFormula%3A%20see%20text%5D%20%28%5BFormula%3A%20see%20text%5D%29%2C%20and%20the%20left%20ventricular%20volume%20and%20endocardial%20area%20were%20found%20to%20be%20the%20most%20critical%20geometric%20features%20for%20accurate%20predictions.%20The%20ML%20model%20predictions%20were%20evaluated%20further%20in%20two%20cases%3A%20%28i%29%20rat-specific%20stiffness%20data%20measured%20using%20ex-vivo%20mechanical%20testing%2C%20and%20%28ii%29%20patient-specific%20estimation%20using%20FE%20inverse%20modeling.%20Excellent%20agreements%20with%20ML%20predictions%20were%20found%20for%20both%20cases.%20The%20trained%20ML%20model%20offers%20a%20feasible%20technology%20to%20estimate%20patient-specific%20myocardial%20properties%2C%20thus%2C%20bridging%20the%20gap%20between%20EDPVR%2C%20as%20a%20confounded%20organ-level%20metric%20for%20tissue%20stiffness%2C%20and%20intrinsic%20tissue-level%20properties.%20These%20properties%20provide%20incremental%20information%20relative%20to%20traditional%20organ-level%20indices%20for%20cardiac%20function%2C%20improving%20the%20clinical%20assessment%20and%20prognosis%20of%20cardiac%20diseases.%22%2C%22date%22%3A%22Mar%2031%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-022-09128-6%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22WGZKEVDQ%22%2C%22BBMMGS3D%22%2C%229T6HXJUI%22%2C%22ZH6PLEMG%22%5D%2C%22dateModified%22%3A%222022-05-04T15%3A31%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22H6UDRBVK%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bhattacharya%20et%20al.%22%2C%22parsedDate%22%3A%222015-09-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBhattacharya%2C%20A.%2C%20Wei%2C%20Q.%2C%20Shin%2C%20J.%20N.%20et%20al.%20%282015%29.%20Autophagy%20is%20required%20for%20neutrophil-mediated%20inflammation.%20%26lt%3Bi%26gt%3BCell%20Rep%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%201731%26%23x2013%3B1739.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.celrep.2015.08.019%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.celrep.2015.08.019%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Autophagy%20is%20required%20for%20neutrophil-mediated%20inflammation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhisek%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qin%22%2C%22lastName%22%3A%22Wei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jin%20Na%22%2C%22lastName%22%3A%22Shin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elmoataz%22%2C%22lastName%22%3A%22Abdel%20Fattah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%20L.%22%2C%22lastName%22%3A%22Bonilla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20Tony%22%2C%22lastName%22%3A%22Eissa%22%7D%5D%2C%22abstractNote%22%3A%22Autophagy%2C%20an%20intracellular%20degradation%20and%20energy%20recycling%20mechanism%2C%20is%20emerging%20as%20an%20important%20regulator%20of%20immune%20responses.%20However%2C%20the%20role%20of%20autophagy%20in%20regulating%20neutrophil%20functions%20is%20not%20known.%20We%20investigated%20neutrophil%20biology%20using%20myeloid-specific%20autophagy-deficient%20mice%20and%20found%20that%20autophagy%20deficiency%20reduced%20neutrophil%20degranulation%20in%20vitro%20and%20in%20vivo.%20Mice%20with%20autophagy%20deficiency%20showed%20reduced%20severity%20of%20several%20neutrophil-mediated%20inflammatory%20and%20autoimmune%20disease%20models%2C%20including%20PMA-induced%20ear%20inflammation%2C%20LPS-induced%20breakdown%20of%20blood-brain%20barrier%2C%20and%20experimental%20autoimmune%20encephalomyelitis.%20NADPH%20oxidase-mediated%20reactive%20oxygen%20species%20generation%20was%20also%20reduced%20in%20autophagy-deficient%20neutrophils%2C%20and%20inhibition%20of%20NADPH%20oxidase%20reduced%20neutrophil%20degranulation%2C%20suggesting%20NADPH%20oxidase%20to%20be%20a%20player%20at%20the%20intersection%20of%20autophagy%20and%20degranulation.%20Overall%2C%20this%20study%20establishes%20autophagy%20as%20an%20important%20regulator%20of%20neutrophil%20functions%20and%20neutrophil-mediated%20inflammation%20in%20vivo.%22%2C%22date%22%3A%22Sep%2022%2C%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.celrep.2015.08.019%22%2C%22ISSN%22%3A%222211-1247%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229T6HXJUI%22%5D%2C%22dateModified%22%3A%222018-06-11T16%3A25%3A01Z%22%7D%7D%2C%7B%22key%22%3A%224YWXL9Y8%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bonilla%20et%20al.%22%2C%22parsedDate%22%3A%222013-09-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBonilla%2C%20D.%20L.%2C%20Bhattacharya%2C%20A.%2C%20Sha%2C%20Y.%20et%20al.%20%282013%29.%20Autophagy%20regulates%20phagocytosis%20by%20modulating%20the%20expression%20of%20scavenger%20receptors.%20%26lt%3Bi%26gt%3BImmunity%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B39%26lt%3B%5C%2Fi%26gt%3B%2C%20537%26%23x2013%3B547.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.immuni.2013.08.026%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.immuni.2013.08.026%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Autophagy%20regulates%20phagocytosis%20by%20modulating%20the%20expression%20of%20scavenger%20receptors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%20L.%22%2C%22lastName%22%3A%22Bonilla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abhisek%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Youbao%22%2C%22lastName%22%3A%22Sha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arshad%22%2C%22lastName%22%3A%22Kan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chinnaswamy%22%2C%22lastName%22%3A%22Jagannath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masaaki%22%2C%22lastName%22%3A%22Komatsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20Tony%22%2C%22lastName%22%3A%22Eissa%22%7D%5D%2C%22abstractNote%22%3A%22Autophagy%20and%20phagocytosis%20are%20conserved%20cellular%20functions%20involved%20in%20innate%20immunity.%20However%2C%20the%20nature%20of%20their%20interactions%20remains%20unclear.%20We%20evaluated%20the%20role%20of%20autophagy%20in%20regulating%20phagocytosis%20in%20macrophages%20from%20myeloid-specific%20autophagy-related%20gene%207-deficient%20%28Atg7%5Cu207b%5C%2F%5Cu207b%29%20mice.%20Atg7%5Cu207b%5C%2F%5Cu207b%20macrophages%20exhibited%20higher%20bacterial%20uptake%20when%20infected%20with%20Mycobacterium%20tuberculosis%20%28Mtb%29%20or%20with%20M.%20tuberculosis%20var.%20bovis%20BCG%20%28BCG%29.%20In%20addition%2C%20BCG-infected%20Atg7%5Cu207b%5C%2F%5Cu207b%20mice%20showed%20increased%20bacterial%20loads%20and%20exacerbated%20lung%20inflammatory%20responses.%20Atg7%5Cu207b%5C%2F%5Cu207b%20macrophages%20had%20increased%20expression%20of%20two%20class%20A%20scavenger%20receptors%3A%20macrophage%20receptor%20with%20collagenous%20structure%20%28MARCO%29%20and%20macrophage%20scavenger%20receptor%201%20%28MSR1%29.%20The%20increase%20in%20scavenger%20receptors%20was%20caused%20by%20increased%20activity%20of%20the%20nuclear%20factor%20%28erythroid-derived%202%29-like%202%20%28NFE2L2%29%20transcription%20factor%20resulting%20from%20accumulated%20sequestosome%201%20%28SQSTM1%20or%20p62%29%20in%20Atg7%5Cu207b%5C%2F%5Cu207b%20macrophages.%20These%20insights%20increase%20our%20understanding%20of%20the%20host-pathogen%20relationship%20and%20suggest%20that%20therapeutic%20strategies%20should%20be%20designed%20to%20include%20modulation%20of%20both%20phagocytosis%20and%20autophagy.%22%2C%22date%22%3A%22Sep%2019%2C%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.immuni.2013.08.026%22%2C%22ISSN%22%3A%221097-4180%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229T6HXJUI%22%5D%2C%22dateModified%22%3A%222018-06-11T16%3A24%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22FA5SLYIQ%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222012-06-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLiu%2C%20X.-D.%2C%20Ko%2C%20S.%2C%20Xu%2C%20Y.%20et%20al.%20%282012%29.%20Transient%20aggregation%20of%20ubiquitinated%20proteins%20is%20a%20cytosolic%20unfolded%20protein%20response%20to%20inflammation%20and%20endoplasmic%20reticulum%20stress.%20%26lt%3Bi%26gt%3BJ%20Biol%20Chem%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B287%26lt%3B%5C%2Fi%26gt%3B%2C%2019687%26%23x2013%3B19698.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1074%5C%2Fjbc.M112.350934%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1074%5C%2Fjbc.M112.350934%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transient%20aggregation%20of%20ubiquitinated%20proteins%20is%20a%20cytosolic%20unfolded%20protein%20response%20to%20inflammation%20and%20endoplasmic%20reticulum%20stress%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xian-De%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soyoung%22%2C%22lastName%22%3A%22Ko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elmoataz%20Abdel%22%2C%22lastName%22%3A%22Fattah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chinnaswamy%22%2C%22lastName%22%3A%22Jagannath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tetsuro%22%2C%22lastName%22%3A%22Ishii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masaaki%22%2C%22lastName%22%3A%22Komatsu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20Tony%22%2C%22lastName%22%3A%22Eissa%22%7D%5D%2C%22abstractNote%22%3A%22Failure%20to%20maintain%20protein%20homeostasis%20%28proteostasis%29%20leads%20to%20accumulation%20of%20unfolded%20proteins%20and%20contributes%20to%20the%20pathogenesis%20of%20many%20human%20diseases.%20Accumulation%20of%20unfolded%20proteins%20in%20the%20endoplasmic%20reticulum%20%28ER%29%20elicits%20unfolded%20protein%20response%20%28UPR%29%20that%20serves%20to%20attenuate%20protein%20translation%2C%20and%20increase%20protein%20refolding%20or%20degradation.%20In%20contrast%20to%20UPR%20in%20the%20ER%2C%20the%20regulatory%20molecules%20operative%20in%20cytosolic%20responses%20and%20their%20potential%20relation%20to%20ER%20stress%20are%20not%20well%20elucidated.%20Aggresome-like%20induced%20structures%20%28ALIS%29%20have%20been%20described%20as%20transient%20aggregation%20of%20ubiquitinated%20proteins%20in%20the%20cytosol.%20In%20this%20study%2C%20we%20show%20that%20cells%20respond%20to%20inflammation%2C%20infection%20or%20ER%20stress%20by%20cytosolic%20formation%20of%20ALIS%2C%20indicating%20that%20ALIS%20formation%20represents%20an%20early%20event%20in%20cellular%20adjustment%20to%20altered%20proteostasis%20that%20occurs%20under%20these%20conditions.%20This%20response%20was%20aided%20by%20rapid%20transcriptional%20up-regulation%20of%20polyubiqutin-binding%20protein%20p62.%20NF-%5Cu03baB%20and%20mTOR%20activation%20were%20also%20required%20for%20ALIS%20formation.%20Importantly%2C%20we%20show%20a%20cross%20talk%20between%20UPR%20in%20the%20ER%20and%20cytosolic%20ALIS.%20Down-regulation%20of%20ER%20UPR%20in%20XBP1%20deficient%20cells%20increases%20cyotosolic%20ALIS%20formation.%20Furthermore%2C%20lysosomal%20activity%20but%20not%20macroautophagy%20is%20responsible%20for%20ALIS%20clearance.%20This%20study%20reveals%20the%20underlying%20regulatory%20mechanisms%20of%20ALIS%20formation%20and%20clearance%2C%20and%20provides%20a%20previously%20unrecognized%20common%20adaptive%20mechanism%20for%20cellular%20responses%20against%20inflammation%20and%20ER%20stress.%22%2C%22date%22%3A%22Jun%2001%2C%202012%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1074%5C%2Fjbc.M112.350934%22%2C%22ISSN%22%3A%221083-351X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229T6HXJUI%22%5D%2C%22dateModified%22%3A%222018-06-11T16%3A24%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22C6JEZF7R%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22D%27Souza%20et%20al.%22%2C%22parsedDate%22%3A%222007-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BD%26%23x2019%3BSouza%2C%20M.%2C%20Garza%2C%20M.%20A.%2C%20Xie%2C%20M.%20et%20al.%20%282007%29.%20Substance%20P%20is%20associated%20with%20heart%20enlargement%20and%20apoptosis%20in%20murine%20dilated%20cardiomyopathy%20induced%20by%20Taenia%20crassiceps%20infection.%20%26lt%3Bi%26gt%3BJ%20Parasitol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B93%26lt%3B%5C%2Fi%26gt%3B%2C%201121%26%23x2013%3B1127.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1645%5C%2FGE-596R1.1%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1645%5C%2FGE-596R1.1%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Substance%20P%20is%20associated%20with%20heart%20enlargement%20and%20apoptosis%20in%20murine%20dilated%20cardiomyopathy%20induced%20by%20Taenia%20crassiceps%20infection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melinda%22%2C%22lastName%22%3A%22D%27Souza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20Armandina%22%2C%22lastName%22%3A%22Garza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%22%2C%22lastName%22%3A%22Xie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joel%22%2C%22lastName%22%3A%22Weinstock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Xiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prema%22%2C%22lastName%22%3A%22Robinson%22%7D%5D%2C%22abstractNote%22%3A%22Dilated%20cardiomyopathy%20%28degeneration%20of%20heart%20muscle%20and%20heart%20enlargement%29%20is%20an%20important%20cause%20of%20heart%20failure%20among%20young%20adults.%20Dilated%20cardiomyopathy%20may%20be%20a%20complication%20during%20or%20after%20various%20viral%2C%20bacterial%2C%20or%20parasitic%20diseases.%20Substance%20P%20%28SP%29%20is%20a%20neurotransmitter%20that%20is%20involved%20in%20the%20pathogenesis%20of%20various%20diseases.%20To%20determine%20whether%20SP%20is%20associated%20with%20cardiac%20changes%20in%20murine%20cysticercosis%2C%20we%20compared%20heart-weight%20to%20body-weight%20ratio%2C%20cardiac%20pathology%2C%20cardiomyocyte%20size%2C%20and%20cardiac-apoptosis%20%28TUNEL%20assay%29%20in%20hearts%20from%20Taenia%20crassiceps-infected%20%28wild-type%20vs.%20SP-knockout%29%20mice.%20We%20noted%20that%2C%20as%20compared%20with%20control%20uninfected%20wild-type%20mice%2C%20elevated%20protein%20levels%20of%20SP%20and%20its%20receptor%20as%20studied%20by%20ELISA%20or%20immunohistochemistry%2C%20respectively%2C%20were%20elevated%20in%20the%20hearts%20of%20parasite-infected%20wild-type%20mice.%20The%20heart-weight%20to%20body-weight%20ratios%20were%20significantly%20higher%20in%20the%20parasite-infected%20wild-type%20mice%20versus%20those%20of%20the%20infected%20SP-knockout%20mice.%20Furthermore%2C%20wild-type%20infected%20mice%20developed%20dilated%20cardiomyopathy%20with%20increased%20chamber%20size%20of%20both%20ventricles%2C%20decreased%20ventricular%20wall%20thickness%2C%20compensatory%20cardiomyocyte%20hypertrophy%2C%20and%20increased%20cardiac%20apoptosis.%20This%20cardiac%20pathology%20did%20not%20develop%20in%20mice%20lacking%20SP%20activity%20%28i.e.%2C%20in%20infected%20SP%20knockout%20mice%29%20or%20in%20uninfected%20mice.%20These%20data%20indicate%20that%20SP%20is%20associated%20with%20cardiac%20changes%20in%20an%20animal%20model%20of%20parasitic%20dilated%20cardiomyopathy.%22%2C%22date%22%3A%22Oct%202007%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1645%5C%2FGE-596R1.1%22%2C%22ISSN%22%3A%220022-3395%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229T6HXJUI%22%5D%2C%22dateModified%22%3A%222018-06-11T16%3A24%3A36Z%22%7D%7D%5D%7D
Guan, Y.-S., Ershad, F., Rao, Z. et al. (2022). Elastic electronics based on micromesh-structured rubbery semiconductor films. Nat Electron. https://doi.org/10.1038/s41928-022-00874-z.
Mendiola, E. A., Neelakantan, S., Xiang, Q. et al. (2022). Contractile adaptation of the left ventricle post-myocardial infarction: predictions by rodent-specific computational modeling. Ann Biomed Eng. https://doi.org/10.1007/s10439-022-03102-z.
Babaei, H., Mendiola, E. A., Neelakantan, S. et al. (2022). A machine learning model to estimate myocardial stiffness from EDPVR. Sci Rep 12, 5433. https://doi.org/10.1038/s41598-022-09128-6.
Bhattacharya, A., Wei, Q., Shin, J. N. et al. (2015). Autophagy is required for neutrophil-mediated inflammation. Cell Rep 12, 1731–1739. https://doi.org/10.1016/j.celrep.2015.08.019.
Bonilla, D. L., Bhattacharya, A., Sha, Y. et al. (2013). Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity 39, 537–547. https://doi.org/10.1016/j.immuni.2013.08.026.
Liu, X.-D., Ko, S., Xu, Y. et al. (2012). Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem 287, 19687–19698. https://doi.org/10.1074/jbc.M112.350934.
D’Souza, M., Garza, M. A., Xie, M. et al. (2007). Substance P is associated with heart enlargement and apoptosis in murine dilated cardiomyopathy induced by Taenia crassiceps infection. J Parasitol 93, 1121–1127. https://doi.org/10.1645/GE-596R1.1.