Mihail G. Chelu, MD, PhD, FHRS

Associate Professor

Director of Electrophysiology, Baylor Heart Clinic

Director of Clinical Electrophysiology Research, Baylor College of Medicine

Medical Director, Inherited Arrhythmia and Cardiomyopathy Clinic

Associate Director, Texas Heart Institute Clinical Cardiac Electrophysiology Fellowship at Baylor St. Luke’s Medical Center

(Houston, Texas)

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Texas Heart Institute Positions

Associate Program Director, Clinical Cardiac Electrophysiology Fellowship

Interests

Academic & Clinical Affiliations

Baylor College of Medicine

Honors, Awards and Memberships

The Texas Heart Institute Academic Professional Staff

Publications

4862227 IWA9EES7 1 alternatives-to-animal-experimentation 10 date desc Chelu 27813 https://www.texasheart.org/wp-content/plugins/zotpress/

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Vijayaraman, P., Sharma, P. S., Cano, Ó. et al. (2023). Comparison of left bundle branch area pacing and biventricular pacing in candidates for resynchronization therapy. J Am Coll Cardiol 82, 228–241. https://doi.org/10.1016/j.jacc.2023.05.006.

Kim, S. E., Khawaja, M., Kim, J. A. et al. (2023). Detection of atrial fibrillation in real world setting in patients with cryptogenic stroke and an implantable loop recorder. Pacing Clin Electrophysiol 46, 788–795. https://doi.org/10.1111/pace.14757.

Kim, J. A. and Chelu, M. G. (2023). Conduction system pacing for cardiac resynchronization therapy: The 31-million-dollar question. Tex Heart Inst J 50, e238118. https://doi.org/10.14503/THIJ-23-8118.

Khawaja, M., Qadeer, Y. K., Siddiqui, R. et al. (2023). Brugada syndrome within Asian populations: State-of-the-art review. Cardiogenetics 13, 61–74. https://doi.org/10.3390/cardiogenetics13020007.

Manoj, P., Kim, J. A., Kim, S. et al. (2022). Sinus node dysfunction: current understanding and future directions. Am J Physiol Heart Circ Physiol. https://doi.org/10.1152/ajpheart.00618.2022.

Kim, J. A. and Chelu, M. G. (2022). Comparison of cryoballoon and radiofrequency ablation for persistent atrial fibrillation: a systematic review and meta-analysis. J Interv Card Electrophysiol. https://doi.org/10.1007/s10840-022-01369-9.

Haddadin, F., Majmundar, M., Jabri, A. et al. (2022). Clinical outcomes and predictors of complications in patients undergoing leadless pacemaker implantation. Heart Rhythm 19, 1289–1296. https://doi.org/10.1016/j.hrthm.2022.03.1226.

Marashly, Q., Najjar, S. N., Hahn, J. et al. (2022). Innovations in ventricular tachycardia ablation. J Interv Card Electrophysiol. https://doi.org/10.1007/s10840-022-01311-z.

Kim, J. A., Khan, K., Kherallah, R. et al. (2022). Innovations in atrial fibrillation ablation. J Interv Card Electrophysiol. https://doi.org/10.1007/s10840-022-01215-y.

Ursaru, A. M., Chelu, M. G., Petriș, A. O. et al. (2022). A Unique Association: Maffucci Syndrome and Cardiac Pathology. Anatol J Cardiol 26, 331–335. https://doi.org/10.5152/AnatolJCardiol.2021.960.