Heinrich Taegtmeyer, MD

Texas Heart Institute Positions

  • Co-Director, Internal Medicine

Interests

  • Heart failure
  • Diabetes
  • Obesity
  • Consultative
  • Outpatient cardiology Electrocardiography

Education

  • Undergraduate:

    University of Freiburg , Germany

  • Postgraduate:

    University Hospitals of Freiburg, Germany

  • Medical School:

    Albert-Ludwigs Universitat Freiburg

  • Residency:

    Boston City Hospital

  • Fellowships:

    Peter Bent Brigham Hospital

Academic & Clinical Affiliations

  • Baylor College of Medicine
  • Memorial Hermann
  • The University of Texas Health Science Center at Houston
  • UT Physicians

Certifications

  • Medizinisches Staatsexamen (Germany)
  • Approbation als Arzt (Germany)
  • American Board of Internal Medicine
  • American Board of Internal Medicine – Cardiovascular Diseases

Honors, Awards and Memberships

  • American College of Cardiology
  • American College of Physicians
  • American Heart Association
  • Chair, writing group for the American Heart Association Scientific Statement on Assess Cardiac Metabolism (2016)
  • Gold Humanism in Medicine Honor Society (2015)
  • Leonard Tow Humanism in Medicine Award, McGovern Medical School (2015)
  • President’s Scholar Award for Research, The University of Texas Health Science Center at Houston (2016)
  • The Texas Heart Institute Academic Professional Staff

Publications

4862227 9DBYXNEE 1 alternatives-to-animal-experimentation 10 date desc Taegtmeyer 2125 https://www.texasheart.org/wp-content/plugins/zotpress/
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Taegtmeyer, H., Ganim, J. and Leuppi-Taegtmeyer, A. B. (2023). Hermann (“Hugh”) Blaschko (1900 - 1993) father of catecholamine metabolism. Cardiology. https://doi.org/10.1159/000528895.
Gutierrez, A. D., Gao, Z., Hamidi, V. et al. (2022). Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes. Cell Rep Med 3, 100813. https://doi.org/10.1016/j.xcrm.2022.100813.
Ashraf, S., Taegtmeyer, H. and Harmancey, R. (2022). Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice. Basic Res Cardiol 117, 33. https://doi.org/10.1007/s00395-022-00942-7.
Karlstaedt, A. and Taegtmeyer, H. (2022). Cardio-onco-metabolism - metabolic vulnerabilities in cancer and the heart. J Mol Cell Cardiol 171, 71–80. https://doi.org/10.1016/j.yjmcc.2022.06.008.
Thomas, S. S., Wu, J., Davogustto, G. et al. (2022). SIRPα mediates IGF1 receptor in cardiomyopathy-induced by chronic kidney disease. Circ Res, 101161CIRCRESAHA121320546. https://doi.org/10.1161/CIRCRESAHA.121.320546.
Taegtmeyer, H., Zaha, V. G. and McGuire, D. K. (2022). 2022 Beijing Winter Olympics: Spotlight on cardiac metabolism. Circulation 145, 1561–1562. https://doi.org/10.1161/CIRCULATIONAHA.122.059905.
Huang Lucas, C. and Taegtmeyer, H. (2022). Letter by Lucas and Taegtmeyer regarding article, “One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction.” Circulation 145, e642–e643. https://doi.org/10.1161/CIRCULATIONAHA.121.058145.
Haidar, A. and Taegtmeyer, H. (2022). Strategies for imaging metabolic remodeling of the heart in obesity and heart failure. Curr Cardiol Rep. https://doi.org/10.1007/s11886-022-01650-3.
Farr, M. (2021). A foot soldier in cardiac metabolism: A conversation with Heinrich Taegtmeyer, MD, DPhil. Circulation 144, 1659–1663. https://doi.org/10.1161/CIRCULATIONAHA.121.058019.
Davogustto, G. E., Salazar, R. L., Vasquez, H. G. et al. (2021). Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol 158, 115–127. https://doi.org/10.1016/j.yjmcc.2021.05.016.