David Aguilar, MD

David Aguilar, MD, is an associate professor in the Department of Internal Medicine, Division of Cardiology at McGovern Medical School He has a dual appointment in the Department of Epidemiology, Human Genetics, and Environmental Sciences at UTHealth’s School of Public Health.

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Dr. Aguilar has advanced training in non-invasive imaging, including echocardiography and nuclear cardiology. He is a Fellow of the American Heart Association. He has been an associate editor and on the editorial board of multiple journals. He has been the principal investigator and co-investigator in multiple grants from the National Institutes of Health and has been actively involved in clinical trials testing new treatment strategies in cardiovascular disease.

His research interests have focused predominantly on the impact of cardiometabolic disease (including type 2 diabetes mellitus) on health outcomes. Dr. Aguilar has authored and co-authored more than 70 publications and book chapters.

As a native Houstonian, Dr. Aguilar is active in the community, previously serving on the Board of Directors for the American Heart Association in Houston. He is also active in teaching endeavors, both locally and nationally.

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Texas Heart Institute Positions

Interests

  • General cardiology
  • Echocardiography
  • Cardiometabolic disease

Education

  • Medical School:

    Baylor College of Medicine

  • Residency:

    Harvard Medical School

  • Fellowships:

    Harvard Medical School

Certifications

  • American Board of Internal Medicine

Publications

4862227 86PR9WQF 1 alternatives-to-animal-experimentation 10 date desc Aguilar 21380 https://www.texasheart.org/wp-content/plugins/zotpress/
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Diaz, P., Coughlin, W., Lam, W. et al. (2022). Describing characteristics of adults with and without congenital heart defects hospitalized with COVID-19. Birth Defects Res. https://doi.org/10.1002/bdr2.2052.
Weiss, M. C., Shih, Y.-H., Bryan, M. S. et al. (2022). Relationships between urinary metals and diabetes traits among Mexican Americans in Starr County, Texas, USA. Biol Trace Elem Res. https://doi.org/10.1007/s12011-022-03165-y.
Kwak, M. J., Chang, M., Chiadika, S. et al. (2022). Healthcare expenditure associated with polypharmacy in older adults with cardiovascular diseases. Am J Cardiol, S0002-9149(22)00030–3. https://doi.org/10.1016/j.amjcard.2022.01.012.
Hasbani, N. R., Ligthart, S., Brown, M. R. et al. (2022). American Heart Association’s Life’s Simple 7: Lifestyle recommendations, polygenic risk, and lifetime risk of coronary heart disease. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.121.053730.
Joseph, J. J., Deedwania, P., Acharya, T. et al. (2022). Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: A scientific statement from the American Heart Association. Circulation, CIR0000000000001040. https://doi.org/10.1161/CIR.0000000000001040.
Brady, V., Whisenant, M., Wang, X. et al. (2022). Characterization of symptoms and symptom clusters for type 2 diabetes using a large nationwide electronic health record database. Diabetes Spectr 35, 159–170. https://doi.org/10.2337/ds21-0064.
Jia, X., Sun, C., Tanaka, H. et al. (2021). Association between circulating Galectin-3 and arterial stiffness in older adults. Vasa 50, 439–445. https://doi.org/10.1024/0301-1526/a000968.
Kobayashi, M., Kwak, M. J., Aguilar, D. et al. (2021). Prescribing trend of inappropriate medications in outpatient clinics for older adults with heart failure in the United States: NAMCS 2012 to 2016. Am J Cardiol 152, 168. https://doi.org/10.1016/j.amjcard.2021.04.002.
Nolan, M. S., Aguilar, D., Misra, A. et al. (2021). Trypanosoma cruzi in nonischemic cardiomyopathy patients, Houston, Texas, USA. Emerg Infect Dis 27, 1958–1960. https://doi.org/10.3201/eid2707.203244.
Hussain, A., Sun, W., Deswal, A. et al. (2021). Association of NT-ProBNP, blood pressure, and cardiovascular events: The ARIC study. J Am Coll Cardiol 77, 559–571. https://doi.org/10.1016/j.jacc.2020.11.063.