Alireza Nazeri, MD

Dr. Alireza Nazeri is a clinical cardiologist and cardiac electrophysiologist specializing in the diagnosis and treatment of heart rhythm disorders (arrhythmias). He is board-certified in cardiovascular disease and in clinical cardiac electrophysiology by the American Board of Internal Medicine.

Show full bio

Dr. Nazeri completed his advanced training in adult cardiology and interventional cardiac electrophysiology at The Texas Heart Institute, where he is a member of the professional staff. He provides cardiac electrophysiology services at Mobitz Heart and Rhythm Center PLLC at the Texas Medical Center and affiliated hospitals in the Houston metropolitan area.

Dr. Nazeri has been and continues to be involved in advanced research in the fields of cardiology and cardiac electrophysiology. His research has been published in prestigious medical journals and presented at national and international cardiology conferences. He is an active fellow of the Heart Rhythm Society (FHRS) and of the American College of Cardiology (FACC).

See Publications

Interests

  • Atrial fibrillation
  • Stroke prevention
  • Heart failure
  • Arrhythmia
  • Public health education

Education

  • Medical School:

    Tehran University of Medical Sciences

  • Residency:

    John Hospital and Medical Center at Wayne State University

Academic & Clinical Affiliations

  • Baylor College of Medicine
  • Baylor St. Luke's Medical Center
  • Houston Methodist Hospital
  • Morbitz Heart & Rhythm Center
  • Texas Children's Hospital

Honors, Awards and Memberships

Publications

4862227 5RXGKSVK 1 alternatives-to-animal-experimentation 10 date desc Nazeri 2027 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2299U3ZRLS%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chrispin%20et%20al.%22%2C%22parsedDate%22%3A%222022-02-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChrispin%2C%20J.%2C%20Mazur%2C%20A.%2C%20Winterfield%2C%20J.%20et%20al.%20%282022%29.%20Non-invasive%20localization%20of%20premature%20ventricular%20focus%3A%20A%20prospective%20multicenter%20study.%20%26lt%3Bi%26gt%3BJ%20Electrocardiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B72%26lt%3B%5C%2Fi%26gt%3B%2C%206%26%23x2013%3B12.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jelectrocard.2022.02.007%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jelectrocard.2022.02.007%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Non-invasive%20localization%20of%20premature%20ventricular%20focus%3A%20A%20prospective%20multicenter%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Chrispin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Mazur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeffrey%22%2C%22lastName%22%3A%22Winterfield%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Valderrabano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harikrishna%22%2C%22lastName%22%3A%22Tandri%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Accurate%20localization%20of%20premature%20ventricular%20contractions%20%28PVC%29%20focus%20is%20a%20prerequisite%20to%20successful%20catheter%20ablation.%5CnOBJECTIVE%3A%20The%20objective%20was%20to%20evaluate%20the%20software%20View%20Into%20Ventricular%20Onset%20%28VIVO%29%20accuracy%20at%20locating%20the%20anatomical%20origins%20for%20premature%20ventricular%20contractions.%20The%20VIVO%20device%20noninvasively%20creates%20a%20model%20of%20the%20patient%26%23039%3Bs%20heart%20and%20torso%2C%20with%20exact%20locations%20of%2012%5Cu2011lead%20ECG%20electrodes%2C%20and%20applies%20a%20mathematical%20algorithm%20from%20surface%20signals%20to%20determine%20the%20origin%20of%20the%20arrhythmia.%20We%20sought%20to%20compare%20the%20agreement%20between%20VIVO-predicted%20locations%20to%20invasive%20electroanatomical%20mapping%20results.%5CnMETHODS%3A%2051%20consecutive%20patients%20who%20presented%20for%20PVC%20ablations%20at%20the%20study%20centers%20were%20recruited.%20VIVO%20images%20were%20collected%20at%20baseline%20preprocedure%20and%20all%20patients%20underwent%20invasive%20electroanatomical%20activation%20mapping%20of%20the%20clinical%20arrhythmia.%20Pacing%20was%20performed%20in%20pre-specified%20locations%20in%20the%20right%20and%5C%2For%20left%20ventricle.%20The%20successful%20sites%20of%20ablation%20and%20the%20pacing%20locations%20were%20compared%20to%20VIVO%20predicted%20locations.%20The%20results%20were%20adjudicated%20by%20physician%20experts%20in%20a%20blinded%20fashion.%5CnRESULTS%3A%20Seven%20patients%20were%20excluded%20from%20analyses.%20VIVO%20accurately%20identified%20the%20origin%20of%20the%20clinical%20premature%20ventricular%20contractions%20in%2044%5C%2F44%20patients%20%28100.00%25%29.%20The%20accuracy%20in%20identifying%20the%20paced%20location%20for%20all%20patients%20%28right%20and%20left%20sides%20of%20the%20heart%29%20was%2099.5%25%20using%20the%20VIVO%20system.%20No%20adverse%20events%20were%20reported.%5CnCONCLUSIONS%3A%20VIVO%20is%20a%20novel%20noninvasive%20system%20that%20could%20be%20used%20to%20help%20guide%20ablation%20procedures%20with%20a%20high%20degree%20of%20accuracy.%20The%20VIVO%20algorithm%20is%20easy%20to%20use%20and%20may%20be%20useful%20in%20the%20workflow%20for%20ventricular%20arrhythmia%20ablation.%22%2C%22date%22%3A%22Feb%2019%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jelectrocard.2022.02.007%22%2C%22ISSN%22%3A%221532-8430%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225RXGKSVK%22%2C%22LNSKD4V3%22%5D%2C%22dateModified%22%3A%222022-03-29T18%3A41%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22US7GFAY9%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ganapathy%20et%20al.%22%2C%22parsedDate%22%3A%222021-06%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGanapathy%2C%20A.%20V.%2C%20%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%2C%20Ashton%2C%20J.%20et%20al.%20%282021%29.%20Contact-force%20recovery%20predicts%20the%20absence%20of%20cardiac%20perforation%20during%20steam%20pops.%20%26lt%3Bi%26gt%3BJ%20Interv%20Card%20Electrophysiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B61%26lt%3B%5C%2Fi%26gt%3B%2C%20181%26%23x2013%3B186.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10840-020-00794-y%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10840-020-00794-y%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Contact-force%20recovery%20predicts%20the%20absence%20of%20cardiac%20perforation%20during%20steam%20pops%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%20V.%22%2C%22lastName%22%3A%22Ganapathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Ashton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krithika%20S.%22%2C%22lastName%22%3A%22Ganapathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Payam%22%2C%22lastName%22%3A%22Safavi-Naeini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohammed%22%2C%22lastName%22%3A%22Saeed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdi%22%2C%22lastName%22%3A%22Rasekh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Cardiac%20perforation%20%28CP%29%20is%20an%20uncommon%20but%20clinically%20important%20complication%20of%20radiofrequency%20ablation%20%28RFA%29.%20We%20previously%20showed%20that%20contact-force%20recovery%20after%20a%20steam%20pop%20predicts%20the%20absence%20of%20CP%20in%20an%20open-chest%20animal%20model%20after%20pericardial%20dissection.%20We%20attempted%20to%20determine%20whether%20this%20also%20applies%20when%20pericardium%20is%20present.%5CnMETHODS%3A%20In%205%20open-chest%20sheep%2C%20left%20atrial%20RFA%20was%20performed%20under%20direct%20observation%20with%20a%207.5F%20ThermoCool%20SmartTouch%20force-sensing%20catheter%20%28Biosense%20Webster%20Inc.%2C%20Irvine%2C%20CA%2C%20USA%29.%20The%20catheter%26%23039%3Bs%20contact%20force%20was%20measured%20every%2050%5Cu00a0ms%20during%20RFA.%20After%20each%20steam%20pop%2C%20the%20presence%20%28%2B%29%20or%20absence%20%28-%29%20of%20CP%20was%20noted%2C%20as%20well%20as%20whether%20pericardium%20was%20present%20over%20the%20ablation%20site.%20Contact-force%20signals%20were%20analyzed%20to%20detect%20contact-force%20recovery.%20Perforation%20rates%20were%20compared%20between%20sites%20with%20or%20without%20pericardium.%5CnRESULTS%3A%20Ninety-six%20steam%20pops%20occurred%3A%2077%20with%20pericardium%20and%2019%20without.%20For%20the%20pericardial%20steam%20pops%2C%20contact-force%20recovery%20occurred%20in%2031%5C%2F60%20CP-%20events%20%2852%25%29%20and%201%5C%2F17%20CP%2B%20events%20%286%25%3B%20P%5Cu2009%3D%5Cu20090.0006%29.%20For%20nonpericardial%20steam%20pops%2C%20contact-force%20recovery%20occurred%20in%204%5C%2F9%20CP-%20events%20%2844%25%29%20and%201%5C%2F10%20CP%2B%20events%20%28P%5Cu2009%3D%5Cu20090.14%29.%20The%20rate%20of%20CP%20was%2022%25%20with%20pericardium%20and%2052%25%20without%20%28P%5Cu2009%3D%5Cu20090.02%29.%20Pericardial%20tissue%20charred%20extensively%20during%20steam%20pop%20induction%2C%20even%20in%20the%20absence%20of%20CP.%5CnCONCLUSIONS%3A%20Contact-force%20recovery%20predicts%20the%20absence%20of%20CP%20during%20RFA%20independently%20of%20whether%20the%20pericardium%20is%20present.%20The%20presence%20of%20the%20pericardium%20may%20decrease%20the%20likelihood%20of%20perforation%2C%20perhaps%20by%20acting%20as%20a%20thermal%20sink.%20Additional%20studies%20are%20needed%20to%20correlate%20these%20results%20with%20clinical%20experience.%22%2C%22date%22%3A%222021-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10840-020-00794-y%22%2C%22ISSN%22%3A%221572-8595%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%228J9J98DL%22%2C%225RXGKSVK%22%2C%22DYX9DYCW%22%2C%22HXDL45T9%22%5D%2C%22dateModified%22%3A%222022-02-14T21%3A41%3A16Z%22%7D%7D%2C%7B%22key%22%3A%228FMVM29T%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nazeri%22%2C%22parsedDate%22%3A%222018-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20%282018%29.%20Clinical%20Challenges%20of%20Using%20Novel%20Oral%20Anticoagulants%20for%20Stroke%20Prevention%20in%20Patients%20with%20Atrial%20Fibrillation.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B45%26lt%3B%5C%2Fi%26gt%3B%2C%20164%26%23x2013%3B165.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-18-6678%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-18-6678%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20Challenges%20of%20Using%20Novel%20Oral%20Anticoagulants%20for%20Stroke%20Prevention%20in%20Patients%20with%20Atrial%20Fibrillation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Jun%202018%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-18-6678%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%225RXGKSVK%22%5D%2C%22dateModified%22%3A%222018-09-13T19%3A48%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22MYZPX9MH%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nazeri%20et%20al.%22%2C%22parsedDate%22%3A%222017-06%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%2C%20Ganapathy%2C%20A.%20V.%2C%20Massumi%2C%20A.%20et%20al.%20%282017%29.%20Effect%20of%20botulinum%20toxin%20on%20inducibility%20and%20maintenance%20of%20atrial%20fibrillation%20in%20ovine%20myocardial%20tissue.%20%26lt%3Bi%26gt%3BPacing%20Clin%20Electrophysiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B40%26lt%3B%5C%2Fi%26gt%3B%2C%20693%26%23x2013%3B702.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.13079%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.13079%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20botulinum%20toxin%20on%20inducibility%20and%20maintenance%20of%20atrial%20fibrillation%20in%20ovine%20myocardial%20tissue%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%20V.%22%2C%22lastName%22%3A%22Ganapathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehran%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Egemen%22%2C%22lastName%22%3A%22Tuzun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%22%2C%22lastName%22%3A%22Stainback%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana-Maria%22%2C%22lastName%22%3A%22Segura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Macarthur%20A.%22%2C%22lastName%22%3A%22Elayda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Aberrant%20vagal%20stimulation%20may%20promote%20the%20generation%20and%20propagation%20of%20atrial%20fibrillation%20%28AF%29.%20Researchers%20have%20suggested%20that%20botulinum%20toxin%20%28BTX%29%2C%20a%20neurotoxin%20that%20decreases%20neural%20vagal%20stimulation%2C%20may%20decrease%20the%20incidence%20of%20postoperative%20AF.%20The%20exact%20electrophysiologic%20mechanism%20underlying%20the%20observations%20and%20histopathologic%20alterations%20associated%20with%20BTX%20are%20unclear.%5CnOBJECTIVE%3A%20To%20investigate%20the%20electrophysiologic%2C%20functional%2C%20and%20histopathologic%20effects%20of%20BTX%20on%20fibrillation%20induction%20in%20ovine%20atria.%5CnMETHODS%3A%20Eight%20sheep%20underwent%20BTX%20injections%20into%20their%20pulmonary%20veins%2C%20atrial%20fat%20pads%2C%20and%20ventricular%20walls.%20Electrophysiology%20with%20pacing%20was%20performed%20at%20baseline%20and%207%20days%20after%20injection%20to%20evaluate%20the%20atrial%20effective%20refractory%20period%20%28ERP%29%20and%20vulnerability%20to%20AF%20with%20and%20without%20vagal%20stimulation.%20Echocardiography%20was%20performed%20at%20baseline%20and%20day%207.%20After%20euthanasia%2C%20histopathologic%20analysis%20was%20performed.%5CnRESULTS%3A%20Seven%20sheep%20completed%20the%20study.%20For%20both%20atria%2C%20there%20was%20significant%20shortening%20in%20the%20ERP%20with%20vagal%20stimulation%20versus%20no%20stimulation%20on%20day%200%20but%20not%20on%20day%207.%20More%20aggressive%20pacing%20was%20required%20to%20induce%20AF%20in%20the%20left%20atrium%20on%20day%207%20than%20on%20day%200.%20Echocardiography%20on%20day%207%20showed%20no%20significant%20changes%20in%20ejection%20fraction%20or%20new%20wall-motion%20abnormalities%20of%20the%20left%20and%20right%20ventricle.%20Histopathologic%20analysis%20showed%20no%20significant%20adverse%20effects.%5CnCONCLUSION%3A%20The%20subacute%20BTX%20effect%20reduced%20the%20vulnerability%20of%20atrial%20tissue%20to%20AF%20induction%20and%20reduced%20the%20vagal%20influence%20on%20atrial%20ERP%20shortening%20compared%20to%20baseline%20levels.%20Direct%20BTX%20injection%20did%20not%20cause%20myocardial%20dysfunction%20or%20histologic%20adverse%20effects.%22%2C%22date%22%3A%22Jun%202017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fpace.13079%22%2C%22ISSN%22%3A%221540-8159%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%22X6Y3USZ6%22%2C%225RXGKSVK%22%2C%22FJXP7WZ4%22%2C%22558WQRIW%22%2C%222NK6UQ4P%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A56%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22NWNJVNTV%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nazeri%20et%20al.%22%2C%22parsedDate%22%3A%222016-12%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%2C%20Elayda%2C%20M.%20A.%2C%20Segura%2C%20A.%20M.%20et%20al.%20%282016%29.%20Comparative%20efficacy%20of%20nebivolol%20and%20metoprolol%20to%20prevent%20tachycardia-induced%20cardiomyopathy%20in%20a%20porcine%20model.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B43%26lt%3B%5C%2Fi%26gt%3B%2C%20477%26%23x2013%3B481.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-15-5495%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-15-5495%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Comparative%20efficacy%20of%20nebivolol%20and%20metoprolol%20to%20prevent%20tachycardia-induced%20cardiomyopathy%20in%20a%20porcine%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22MacArthur%20A.%22%2C%22lastName%22%3A%22Elayda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20Maria%22%2C%22lastName%22%3A%22Segura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20F.%22%2C%22lastName%22%3A%22Stainback%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joanna%22%2C%22lastName%22%3A%22Nathan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vei-Vei%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22Bove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luiz%22%2C%22lastName%22%3A%22Sampaio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Grace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%5D%2C%22abstractNote%22%3A%22Chronic%20tachycardia%20is%20a%20well-known%20cause%20of%20nonischemic%20cardiomyopathy.%20We%20hypothesized%20that%20nebivolol%2C%20a%20%5Cu03b2-blocker%20with%20nitric%20oxide%20activity%2C%20would%20be%20superior%20to%20a%20pure%20%5Cu03b2-blocker%20in%20preventing%20tachycardia-induced%20cardiomyopathy%20in%20a%20porcine%20model.%20Fifteen%20healthy%20Yucatan%20pigs%20were%20randomly%20assigned%20to%20receive%20nebivolol%2C%20metoprolol%2C%20or%20placebo%20once%20a%20day.%20All%20pigs%20underwent%20dual-chamber%20pacemaker%20implantation.%20The%20medication%20was%20started%20the%20day%20after%20the%20pacemaker%20implantation.%20On%20day%207%20after%20implantation%2C%20each%20pacemaker%20was%20set%20at%20atrioventricular%20pace%20%28rate%2C%20170%20beats%5C%2Fmin%29%2C%20and%20the%20pigs%20were%20observed%20for%20another%207%20weeks.%20Transthoracic%20echocardiograms%2C%20serum%20catecholamine%20levels%2C%20and%20blood%20chemistry%20data%20were%20obtained%20at%20baseline%20and%20at%20the%20end%20of%20the%20study.%20At%20the%20end%20of%20week%208%2C%20the%20pigs%20were%20euthanized%2C%20and%20complete%20histopathologic%20studies%20were%20performed.%20All%20the%20pigs%20developed%20left%20ventricular%20cardiomyopathy%20but%20remained%20hemodynamically%20stable%20and%20survived%20to%20the%20end%20of%20the%20study.%20The%20mean%20left%20ventricular%20ejection%20fraction%20decreased%20from%20baseline%20by%2034%25%2C%2020%25%2C%20and%2020%25%20in%20the%20nebivolol%2C%20metoprolol%2C%20and%20placebo%20groups%2C%20respectively.%20These%20changes%20did%20not%20differ%20significantly%20among%20the%203%20groups%20%28P%20%3D0.51%29.%20Histopathologic%20analysis%20revealed%20mild%20left%20ventricular%20perivascular%20fibrosis%20with%20cardiomyocyte%20hypertrophy%20in%2014%20of%20the%2015%20pigs.%20Both%20nebivolol%20and%20metoprolol%20failed%20to%20prevent%20cardiomyopathy%20in%20our%20animal%20model%20of%20persistent%20tachycardia%20and%20a%20high%20catecholamine%20state.%22%2C%22date%22%3A%22Dec%202016%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-15-5495%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%223YV626VF%22%2C%22X6Y3USZ6%22%2C%225RXGKSVK%22%2C%22558WQRIW%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A56%3A05Z%22%7D%7D%2C%7B%22key%22%3A%2248HHVJGJ%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pollet%20et%20al.%22%2C%22parsedDate%22%3A%222016-06%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPollet%2C%20M.%2C%20Birnbaum%2C%20Y.%20and%20%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20%282016%29.%20Heart%20block%20in%20a%20pacemaker%3A%20does%20this%20mean%20trouble%3F%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B43%26lt%3B%5C%2Fi%26gt%3B%2C%20270%26%23x2013%3B271.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-16-5846%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-16-5846%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Heart%20block%20in%20a%20pacemaker%3A%20does%20this%20mean%20trouble%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Pollet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yochai%22%2C%22lastName%22%3A%22Birnbaum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Jun%202016%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-16-5846%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22K4H4V8VZ%22%2C%225RXGKSVK%22%2C%22BQISFY8E%22%5D%2C%22dateModified%22%3A%222018-11-14T14%3A50%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22SJQG556D%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hoang%20et%20al.%22%2C%22parsedDate%22%3A%222016-05-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHoang%2C%20V.%2C%20%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20and%20Birnbaum%2C%20Y.%20%282016%29.%20Pacemaker%20gone%20wrong%3F%20%26lt%3Bi%26gt%3BJournal%20of%20Electrocardiology%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B49%26lt%3B%5C%2Fi%26gt%3B%2C%20473%26%23x2013%3B475.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jelectrocard.2016.02.008%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jelectrocard.2016.02.008%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pacemaker%20gone%20wrong%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vu%22%2C%22lastName%22%3A%22Hoang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yochai%22%2C%22lastName%22%3A%22Birnbaum%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22May%201%2C%202016%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jelectrocard.2016.02.008%22%2C%22ISSN%22%3A%220022-0736%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0022073616000637%22%2C%22collections%22%3A%5B%22K4H4V8VZ%22%2C%225RXGKSVK%22%5D%2C%22dateModified%22%3A%222019-01-04T20%3A47%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22FZ3P5JDH%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Safavi-Naeini%20et%20al.%22%2C%22parsedDate%22%3A%222014-12%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSafavi-Naeini%2C%20P.%2C%20Shanoon%2C%20F.%2C%20%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20et%20al.%20%282014%29.%20Cryoballoon%20pressure%20waveform%20change%20during%20balloon%20inflation%20is%20not%20a%20reliable%20predictor%20of%20adequate%20pulmonary%20vein%20occlusion.%20%26lt%3Bi%26gt%3BPacing%20Clin%20Electrophysiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%2C%201702%26%23x2013%3B1707.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.12491%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.12491%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cryoballoon%20pressure%20waveform%20change%20during%20balloon%20inflation%20is%20not%20a%20reliable%20predictor%20of%20adequate%20pulmonary%20vein%20occlusion%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Payam%22%2C%22lastName%22%3A%22Safavi-Naeini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farah%22%2C%22lastName%22%3A%22Shanoon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdi%22%2C%22lastName%22%3A%22Rasekh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohammad%22%2C%22lastName%22%3A%22Saeed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Massumi%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Cryoballoon%20ablation%20of%20pulmonary%20veins%20%28PVs%29%20is%20widely%20used%20to%20treat%20atrial%20fibrillation%20%28AF%29.%20Successful%20ablation%20requires%20occluding%20the%20PVs%20by%20cryoballoon.%20Angiography%20is%20a%20standard%20method%20of%20assessing%20PV%20occlusion.%20To%20decrease%20contrast%20doses%20and%20overcome%20potential%20contraindications%20%28e.g.%2C%20allergy%20to%20contrast%2C%20renal%20disease%29%2C%20alternative%20methods%20have%20been%20tested%2C%20including%20intracardiac%20echocardiography%2C%20transesophageal%20echocardiography-color%20flow%20Doppler%2C%20and%20distal%20cryoballoon%20pressure%20monitoring.%5CnOBJECTIVE%3A%20We%20evaluated%20pressure%20monitoring%5Cu2019s%20accuracy%20in%20detecting%20PV%20occlusion%20during%20cryoballoon%20ablation.%5CnMETHODS%3A%20We%20studied%2072%20PVs%20in%2018%20nonconsecutive%20patients%20%28mean%20age%2068%20%5Cu00b1%208%20years%3B%2013%20male%29%20who%20underwent%20cryoballoon%20ablation%20for%20paroxysmal%20AF.%20In%2067%20PVs%2C%20we%20documented%20the%20point%20at%20which%20the%20recorded%20pressure%20waveform%20at%20the%20distal%20tip%20of%20the%20inflated%20cryoballoon%20transformed%20from%20a%20left%20atrial%20into%20a%20pulmonary%20arterial%20pressure%20waveform.%20PV%20occlusion%20was%20confirmed%20by%20concurrent%20PV%20angiography%20through%20the%20distal%20balloon%20channel.%20Occlusion%20was%20rated%20on%20a%20I%5Cu2013IV%20scale%20in%20which%20I%20indicated%20poor%20occlusion%20with%20major%20leakage%20and%20IV%20indicated%20complete%20occlusion%20without%20leakage.%5CnRESULTS%3A%20In%2043%20of%2067%20PVs%20%2864%25%29%2C%20the%20change%20in%20the%20pressure%20waveform%20from%20left%20atrial%20to%20pulmonary%20arterial%20was%20associated%20with%20complete%20PV%20occlusion%20%28grade%20IV%29%2C%20confirmed%20by%20angiography.%20In%20the%20other%2024%20PVs%2C%20complete%20occlusion%20was%20achieved%20by%20further%20movement%20of%20the%20cryoballoon%20under%20intracardiac%20echocardiographic%20guidance%20and%20angiographic%20confirmation.%20All%2067%20PVs%20were%20electrically%20isolated%20with%20cryoballoon.%5CnCONCLUSIONS%3A%20The%20change%20in%20pressure%20waveforms%20at%20the%20distal%20tip%20of%20inflated%20cryoballoon%20is%20not%20a%20reliable%20predictor%20of%20complete%20PV%20occlusion%20during%20cryoballoon%20ablation.%22%2C%22date%22%3A%22Dec%202014%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fpace.12491%22%2C%22ISSN%22%3A%221540-8159%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%228J9J98DL%22%2C%225RXGKSVK%22%2C%22DYX9DYCW%22%2C%22HXDL45T9%22%5D%2C%22dateModified%22%3A%222022-02-14T21%3A24%3A59Z%22%7D%7D%2C%7B%22key%22%3A%226IMDKN9Z%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nazeri%20et%20al.%22%2C%22parsedDate%22%3A%222014-09%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%2C%20Ganapathy%2C%20A.%2C%20Massumi%2C%20A.%20et%20al.%20%282014%29.%20Contact-force%20recovery%20can%20predict%20cardiac%20perforation%20during%20radiofrequency%20ablation.%20%26lt%3Bi%26gt%3BPacing%20Clin%20Electrophysiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%2C%201129%26%23x2013%3B1132.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.12409%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.12409%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Contact-force%20recovery%20can%20predict%20cardiac%20perforation%20during%20radiofrequency%20ablation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%22%2C%22lastName%22%3A%22Ganapathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehran%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garth%22%2C%22lastName%22%3A%22Constantine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaul%22%2C%22lastName%22%3A%22Raz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20During%20radiofrequency%20ablation%20%28RFA%29%2C%20the%20ability%20to%20know%20whether%20a%20steam%20pop%20has%20led%20to%20cardiac%20perforation%20%28CP%29%20would%20be%20of%20profound%20clinical%20significance.%20We%20aimed%20to%20determine%20whether%20catheter%20contact-force%20characteristics%20can%20predict%20whether%20a%20steam%20pop%20during%20RFA%20causes%20CP.%5CnMETHODS%3A%20We%20used%20a%207.5F%20Thermocool%5Cu00ae%20Smarttouch%5Cu2122%20force-sensing%20catheter%20%28Biosense%20Webster%20Inc.%2C%20Diamond%20Bar%2C%20CA%2C%20USA%29%20to%20perform%20open-chest%20left%20atrial%20RFA%20under%20direct%20visualization%20in%20four%20sheep.%20We%20measured%20the%20contact%20force%20and%20its%20direction%20every%2050%20ms%20during%20RFA.%20At%20each%20steam%20pop%2C%20we%20noted%20whether%20CP%20occurred.%20We%20then%20analyzed%20the%20contact-force%20signals%20to%20determine%20whether%20specific%20features%20predicted%20the%20presence%20%28%2B%29%20or%20absence%20%28-%29%20of%20CP.%5CnRESULTS%3A%20A%20total%20of%2024%20steam%20pops%20occurred%3B%2010%20were%20CP%2B%20and%2014%20were%20CP-.%20At%20the%20time%20of%20CP%2B%20and%20CP-%20events%2C%20the%20contact%20force%20was%2050%20%5Cu00b1%2025%20and%2040%20%5Cu00b1%2015%20g%2C%20respectively%20%28P%20%3D%200.146%29.%20All%20steam-pop%20events%20were%20associated%20with%20a%20rapid%20drop-off%20in%20contact%20force%2C%20but%2010%20of%20the%2014%20CP-%20events%20showed%20an%20immediate%20contact-force%20rebound%2C%20whereas%20none%20of%20the%20CP%2B%20events%20did.%20This%20rebound%20presumably%20occurred%20as%20the%20catheter%20tip%20resumed%20contact%20with%20the%20left%20atrial%20wall.%20The%20average%20contact-force%20rebound%20equaled%2080-100%25%20of%20the%20contact-force%20drop-off.%5CnCONCLUSIONS%3A%20The%20ability%20to%20measure%20catheter%20contact%20force%20during%20RFA%20is%20a%20valuable%20asset%2C%20as%20contact-force%20recovery%20may%20be%20used%20to%20predict%20CP.%20Further%20studies%20are%20warranted%20to%20validate%20our%20findings%20in%20the%20clinical%20setting.%22%2C%22date%22%3A%22Sep%202014%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fpace.12409%22%2C%22ISSN%22%3A%221540-8159%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%225RXGKSVK%22%2C%22FJXP7WZ4%22%2C%222NK6UQ4P%22%5D%2C%22dateModified%22%3A%222022-02-14T21%3A40%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22QD9DFQC9%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Massumi%20et%20al.%22%2C%22parsedDate%22%3A%222013-03-15%22%2C%22numChildren%22%3A6%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMassumi%2C%20A.%2C%20Chelu%2C%20M.%20G.%2C%20%26lt%3Bstrong%26gt%3BNazeri%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20et%20al.%20%282013%29.%20Initial%20experience%20with%20a%20novel%20percutaneous%20left%20atrial%20appendage%20exclusion%20device%20in%20patients%20with%20atrial%20fibrillation%2C%20increased%20stroke%20risk%2C%20and%20contraindications%20to%20anticoagulation.%20%26lt%3Bi%26gt%3BAm%20J%20Cardiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B111%26lt%3B%5C%2Fi%26gt%3B%2C%20869%26%23x2013%3B873.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.amjcard.2012.11.061%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.amjcard.2012.11.061%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Initial%20experience%20with%20a%20novel%20percutaneous%20left%20atrial%20appendage%20exclusion%20device%20in%20patients%20with%20atrial%20fibrillation%2C%20increased%20stroke%20risk%2C%20and%20contraindications%20to%20anticoagulation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Massumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mihail%20Gabriel%22%2C%22lastName%22%3A%22Chelu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alireza%22%2C%22lastName%22%3A%22Nazeri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20Allen%22%2C%22lastName%22%3A%22May%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hamid%22%2C%22lastName%22%3A%22Afshar-Kharaghan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohammad%22%2C%22lastName%22%3A%22Saeed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mehdi%22%2C%22lastName%22%3A%22Razavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdi%22%2C%22lastName%22%3A%22Rasekh%22%7D%5D%2C%22abstractNote%22%3A%22Atrial%20fibrillation%20%28AF%29%20increases%20by%20fivefold%20a%20patient%26%23039%3Bs%20risk%20for%20thromboembolic%20stroke.%20The%20main%20source%20of%20emboli%20in%20AF%20is%20the%20left%20atrial%20appendage%20%28LAA%29.%20Therefore%2C%20LAA%20closure%20could%20reduce%20the%20risk%20for%20thromboembolic%20events%20in%20AF.%20The%20investigators%20report%20the%20first%20United%20States%20experience%20with%20a%20novel%20percutaneous%20LAA%20closure%20device%2C%20the%20Lariat%20snare%20device%2C%20and%20its%20outcomes%20in%2021%20patients%20with%20AF%2C%20CHADS2%20scores%20%5Cu22652%2C%20and%20contraindications%20to%20anticoagulation.%20The%20LAA%20was%20closed%20with%20a%20snare%20containing%20suture%20from%20within%20the%20pericardial%20space.%20The%20intraoperative%20success%20of%20the%20procedure%20was%20confirmed%20by%20left%20atrial%20angiography%20and%20transesophageal%20echocardiographic%20color%20Doppler%20flow.%20The%20effectiveness%20of%20the%20procedure%20was%20evaluated%20by%20follow-up%20transesophageal%20echocardiography.%20The%20incidence%20of%20periprocedural%20and%20short-term%20complications%20was%20assessed%20by%20reviewing%20medical%20records.%20Twenty%20patients%20%28100%25%29%20had%20successful%20LAA%20exclusion%20that%20was%20preserved%20at%2096%20%5Cu00b1%2077%20days.%20No%20patient%20had%20a%20stroke%20during%20an%20average%20of%20352%20%5Cu00b1%20143%20days%20of%20follow-up.%20One%20patient%20had%20right%20ventricular%20perforation%20and%20tamponade%20that%20required%20surgical%20exploration%20and%20repair.%20Two%20patients%20required%20prolonged%20hospitalization%3A%201%20because%20of%20pericardial%20effusion%20that%20required%20repeat%20pericardiocentesis%20and%201%20because%20of%20noncardiac%20co-morbidities.%20Three%20patients%20developed%20pericarditis%20%26lt%3B1%20month%20after%20the%20procedure%2C%20of%20whom%201%5Cu00a0had%20associated%20pericardial%20effusion%20that%20required%20drainage.%20In%20conclusion%2C%20percutaneous%20LAA%20exclusion%20can%20be%20achieved%20successfully%20and%20with%20an%20acceptable%20incidence%20of%20periprocedural%20and%20short-term%20complications.%20Further%20studies%20are%20needed%20to%20determine%20whether%20LAA%20exclusion%20lowers%20the%20long-term%20risk%20for%20thromboembolic%20events%20in%20patients%20with%20AF%20and%20contraindications%20to%20anticoagulation.%22%2C%22date%22%3A%22Mar%2015%2C%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.amjcard.2012.11.061%22%2C%22ISSN%22%3A%221879-1913%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22MQPA457U%22%2C%228J9J98DL%22%2C%225RXGKSVK%22%2C%22DYX9DYCW%22%2C%22IWA9EES7%22%5D%2C%22dateModified%22%3A%222022-02-14T21%3A40%3A48Z%22%7D%7D%5D%7D
Chrispin, J., Mazur, A., Winterfield, J. et al. (2022). Non-invasive localization of premature ventricular focus: A prospective multicenter study. J Electrocardiol 72, 6–12. https://doi.org/10.1016/j.jelectrocard.2022.02.007.
Ganapathy, A. V., Nazeri, A., Ashton, J. et al. (2021). Contact-force recovery predicts the absence of cardiac perforation during steam pops. J Interv Card Electrophysiol 61, 181–186. https://doi.org/10.1007/s10840-020-00794-y.
Nazeri, A. (2018). Clinical Challenges of Using Novel Oral Anticoagulants for Stroke Prevention in Patients with Atrial Fibrillation. Tex Heart Inst J 45, 164–165. https://doi.org/10.14503/THIJ-18-6678.
Nazeri, A., Ganapathy, A. V., Massumi, A. et al. (2017). Effect of botulinum toxin on inducibility and maintenance of atrial fibrillation in ovine myocardial tissue. Pacing Clin Electrophysiol 40, 693–702. https://doi.org/10.1111/pace.13079.
Nazeri, A., Elayda, M. A., Segura, A. M. et al. (2016). Comparative efficacy of nebivolol and metoprolol to prevent tachycardia-induced cardiomyopathy in a porcine model. Tex Heart Inst J 43, 477–481. https://doi.org/10.14503/THIJ-15-5495.
Pollet, M., Birnbaum, Y. and Nazeri, A. (2016). Heart block in a pacemaker: does this mean trouble? Tex Heart Inst J 43, 270–271. https://doi.org/10.14503/THIJ-16-5846.
Hoang, V., Nazeri, A. and Birnbaum, Y. (2016). Pacemaker gone wrong? Journal of Electrocardiology 49, 473–475. https://doi.org/10.1016/j.jelectrocard.2016.02.008.
Safavi-Naeini, P., Shanoon, F., Nazeri, A. et al. (2014). Cryoballoon pressure waveform change during balloon inflation is not a reliable predictor of adequate pulmonary vein occlusion. Pacing Clin Electrophysiol 37, 1702–1707. https://doi.org/10.1111/pace.12491.
Nazeri, A., Ganapathy, A., Massumi, A. et al. (2014). Contact-force recovery can predict cardiac perforation during radiofrequency ablation. Pacing Clin Electrophysiol 37, 1129–1132. https://doi.org/10.1111/pace.12409.
Massumi, A., Chelu, M. G., Nazeri, A. et al. (2013). Initial experience with a novel percutaneous left atrial appendage exclusion device in patients with atrial fibrillation, increased stroke risk, and contraindications to anticoagulation. Am J Cardiol 111, 869–873. https://doi.org/10.1016/j.amjcard.2012.11.061.