Alexis E. Shafii, MD

Dr. Alexis Shafii is a cardiothoracic surgeon with expertise in thoracic transplantation and adult cardiac surgery.

Show full bio

His clinical focus includes thoracic organ failure, heart and lung transplantation as well as implantation of mechanical circulatory support devices. He is the surgical director of the heart transplant program at Baylor St. Luke’s Medical Center, and previously directed transplant programs at major medical centers in Dallas and Kentucky.

Dr. Shafii also treats adult acquired cardiac diseases, including coronary artery disease, heart valve disease, and aortic pathologies. His research efforts focus on heart and lung transplantation, ventricular assist devices, and extracorporeal membrane oxygenation (ECMO).

See Publications

Interests

  • Heart and Lung Transplant
  • Cardiac Surgery

Education

  • Undergraduate:

    Boston College

  • Medical School:

    University of South Florida College of Medicine

  • Residency:

    University of South Florida College of Medicine

  • Fellowships:

    Cleveland Clinic Foundation

Certifications

  • American Board of Surgery
  • American Board of Thoracic Surgery

Honors, Awards and Memberships

Publications

4862227 ZMAN8MMI 1 alternatives-to-animal-experimentation 10 date desc Shafii 33470 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22VWM22A97%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ali%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAli%2C%20A.%2C%20Gray%2C%20Z.%2C%20Loor%2C%20G.%20et%20al.%20%282024%29.%20Minimally%20Invasive%20Mitral%20Valve%20Surgery%20Using%20a%20Cold%20Fibrillatory%20Cardiac%20Arrest%20Technique%20in%20Patients%20With%20Prior%20Cardiac%20Surgery.%20%26lt%3Bi%26gt%3BTexas%20Heart%20Institute%20Journal%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B51%26lt%3B%5C%2Fi%26gt%3B%2C%20e238167.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-23-8167%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-23-8167%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Minimally%20Invasive%20Mitral%20Valve%20Surgery%20Using%20a%20Cold%20Fibrillatory%20Cardiac%20Arrest%20Technique%20in%20Patients%20With%20Prior%20Cardiac%20Surgery%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmed%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zachary%22%2C%22lastName%22%3A%22Gray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Todd%20K.%22%2C%22lastName%22%3A%22Rosengart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20K.%22%2C%22lastName%22%3A%22Liao%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objective%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Minimally%20invasive%20mitral%20valve%20surgery%20%28mini-MVS%29%20is%20typically%20reserved%20for%20patients%20who%20have%20not%20undergone%20open%20cardiac%20surgery.%20In%20the%20reoperative%20setting%2C%20using%20intrapericardial%20dissection%20for%20crossclamping%20the%20aorta%20through%20a%20minimally%20invasive%20approach%20can%20be%20difficult%20and%2C%20at%20times%2C%20risky.%20Cold%20fibrillatory%20cardiac%20arrest%20%28CFCA%29%20with%20systemic%20cardiopulmonary%20bypass%20without%20cross-clamping%20is%20a%20well-described%20technique%3B%20however%2C%20data%20about%20its%20safety%20for%20patients%20who%20undergo%20reoperative%20mini-MVS%20are%20limited.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20for%2034%20patients%20who%20underwent%20reoperative%20mini-MVS%20with%20CFCA%20from%20March%202017%20to%20March%202022%20were%20reviewed%20retrospectively.%20A%20mini%20right%20thoracotomy%20%28n%20%3D%2030%29%20or%20robotic%20%28n%20%3D%204%29%20approach%20was%20used.%20Systemic%20hypothermia%20was%20induced%20to%20a%20target%20temperature%20of%2025%20%5Cu00b0C.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Patient%20mean%20%28SD%29%20age%20was%2064.5%20%289.6%29%20years%2C%20and%2015%20of%2034%20%2844.1%25%29%20patients%20were%20women.%20Of%20those%2034%20patients%2C%2023%20%2867.6%25%29%20had%20severe%20regurgitation%2C%20and%2011%20%2832.4%25%29%20had%20severe%20stenosis.%20Before%20mini-MVS%2C%2028%20patients%20had%20undergone%20valve%20surgery%2C%20and%208%20had%20undergone%20coronary%20artery%20bypass%20graft%20surgery.%20The%20mitral%20valve%20was%20repaired%20in%205%20of%2034%20%2814.7%25%29%20and%20replaced%20in%2029%20of%2034%20%2885.3%25%29%20patients.%20No%20difference%20was%20observed%20in%20preoperative%20and%20postoperative%20left%20ventricular%20function%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3D%20.82%29.%20In%201%20patient%2C%20kidney%20failure%20developed%20that%20necessitated%20dialysis.%20No%20postoperative%20stroke%20or%20mortality%20at%2030%20days%20occurred.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mini-MVS%20with%20CFCA%20is%20well%20tolerated%20in%20patients%20with%20prior%20cardiac%20surgery.%20Myocardial%20function%20was%20not%20impaired%2C%20nor%20was%20the%20risk%20of%20stroke%20increased%20in%20this%20cohort%2C%20indicating%20that%20CFCA%20is%20a%20safe%20alternative%20in%20this%20high-risk%20population.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-23-8167%22%2C%22ISSN%22%3A%221526-6702%2C%200730-2347%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fthij.kglmeridian.com%5C%2Fview%5C%2Fjournals%5C%2Fthij%5C%2F51%5C%2F2%5C%2Farticle-e238167.xml%22%2C%22collections%22%3A%5B%22ZMAN8MMI%22%5D%2C%22dateModified%22%3A%222025-02-06T23%3A12%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22M6EGKCJF%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Allen%20et%20al.%22%2C%22parsedDate%22%3A%222022-10-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAllen%2C%20S.%20R.%2C%20Slaughter%2C%20M.%20S.%2C%20Ahmed%2C%20M.%20M.%20et%20al.%20%282022%29.%20COMPETENCE%20Trial%3A%20The%20EVAHEART%202%20continuous%20flow%20left%20ventricular%20assist%20device.%20%26lt%3Bi%26gt%3BJ%20Heart%20Lung%20Transplant%26lt%3B%5C%2Fi%26gt%3B%2C%20S1053-2498%2822%2902180%26%23x2013%3B5.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.healun.2022.10.011%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.healun.2022.10.011%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COMPETENCE%20Trial%3A%20The%20EVAHEART%202%20continuous%20flow%20left%20ventricular%20assist%20device%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20R.%22%2C%22lastName%22%3A%22Allen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20S.%22%2C%22lastName%22%3A%22Slaughter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mustafa%20M.%22%2C%22lastName%22%3A%22Ahmed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlo%20R.%22%2C%22lastName%22%3A%22Bartoli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravi%22%2C%22lastName%22%3A%22Dhingra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20F.%22%2C%22lastName%22%3A%22Egnaczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjeev%20K.%22%2C%22lastName%22%3A%22Gulati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20S.%22%2C%22lastName%22%3A%22Kiernan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudius%22%2C%22lastName%22%3A%22Mahr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%20M.%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tadashi%22%2C%22lastName%22%3A%22Motomura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masahiro%22%2C%22lastName%22%3A%22Ono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ashwin%22%2C%22lastName%22%3A%22Ravichandran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Behzad%22%2C%22lastName%22%3A%22Soleimani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoshiya%22%2C%22lastName%22%3A%22Toyoda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leora%20T.%22%2C%22lastName%22%3A%22Yarboro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20D.%22%2C%22lastName%22%3A%22Dowling%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Continuous%20flow%20left%20ventricular%20assist%20devices%20have%20improved%20outcomes%20in%20patients%20with%20end-stage%20heart%20failure%20that%20require%20mechanical%20circulatory%20support.%20Current%20devices%20have%20an%20adverse%20event%20profile%20that%20has%20hindered%20widespread%20application.%20The%20EVAHEART%5Cu00ae2%20left%20ventricular%20assist%20device%20%28EVA2%29%20has%20design%20features%20such%20as%20large%20blood%20gaps%2C%20lower%20pump%20speeds%20and%20an%20inflow%20cannula%20that%20does%20not%20protrude%20into%20the%20left%20ventricle%20that%20may%20mitigate%20the%20adverse%20events%20currently%20seen%20with%20other%20continuous%20flow%20devices.%5CnMETHODS%3A%20A%20prospective%2C%20multi-center%20randomized%20non-inferiority%20study%2C%20COMPETENCE%20Trial%2C%20is%20underway%20to%20assess%20non-inferiority%20of%20the%20EVA2%20to%20the%20HeartMate%203%20LVAS%20when%20used%20for%20the%20treatment%20of%20refractory%20advanced%20heart%20failure.%20The%20primary%20end-point%20is%20a%20composite%20of%20the%20individual%20primary%20outcomes%3A%20Survival%20to%20cardiac%20transplant%20or%20device%20explant%20for%20recovery%3B%20Free%20from%20disabling%20stroke%3B%20Free%20from%20severe%20Right%20Heart%20Failure%20after%20implantation%20of%20original%20device.%20Randomization%20is%20in%20a%202%3A1%20%28EVA2%3AHM3%29%20ratio.%5CnRESULTS%3A%20The%20first%20patient%20was%20enrolled%20into%20the%20COMPETENCE%20Trial%20in%20December%20of%202020%2C%20and%2025%20subjects%20%2816%20EVA2%20and%209%20HM3%29%20are%20currently%20enrolled.%20Enrollment%20of%20a%20safety%20cohort%20is%20projected%20to%20be%20completed%20by%20third%20quarter%20of%202022%20at%20which%20time%20an%20interim%20analysis%20will%20be%20performed.%20Short-term%20cohort%20%2892%20EVA2%20subjects%29%20and%20long-term%20cohort%20is%20expected%20to%20be%20completed%20by%20the%20end%20of%202023%20and%202024%2C%20respectively.%5CnCONCLUSIONS%3A%20Contemporary%20risk%20scores%20were%20therapy%20responsive%20in%20FREEDOM-EV%20and%20early%20improvements%20predicted%20subsequent%20outcomes.%20This%20post%20hoc%20analysis%20suggests%20that%20risk%20scores%20may%20be%20a%20surrogate%20for%20clinical%20worsening.%22%2C%22date%22%3A%22Oct%2019%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.healun.2022.10.011%22%2C%22ISSN%22%3A%221557-3117%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22ZMAN8MMI%22%2C%22QF52JASW%22%5D%2C%22dateModified%22%3A%222022-12-01T19%3A16%3A47Z%22%7D%7D%2C%7B%22key%22%3A%229SC85ZEF%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Inchaustegui%20et%20al.%22%2C%22parsedDate%22%3A%222022-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BInchaustegui%2C%20C.%20A.%2C%20Patel%2C%20A.%2C%20Lamba%2C%20H.%20K.%20et%20al.%20%282022%29.%20Impact%20of%20time%20off%20anticoagulation%20in%20patients%20with%20continuous-flow%20left%20ventricular%20assist%20devices.%20%26lt%3Bi%26gt%3BJ%20Artif%20Organs%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-022-01367-8%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-022-01367-8%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20time%20off%20anticoagulation%20in%20patients%20with%20continuous-flow%20left%20ventricular%20assist%20devices%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%20A.%22%2C%22lastName%22%3A%22Inchaustegui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ashley%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harveen%20K.%22%2C%22lastName%22%3A%22Lamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%22%2C%22lastName%22%3A%22Arunthamakun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Ting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajith%20P.%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joggy%20K.%22%2C%22lastName%22%3A%22George%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20K.%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20B.%22%2C%22lastName%22%3A%22Civitello%22%7D%5D%2C%22abstractNote%22%3A%22Patients%20with%20left%20ventricular%20assist%20devices%20%28LVADs%29%20receive%20anticoagulation%20to%20decrease%20the%20risk%20of%20thrombosis.%20Various%20circumstances%20require%20discontinuing%20anticoagulation%20in%20LVAD%20patients%2C%20but%20the%20risks%20entailed%20are%20not%20well%20defined.%20In%20a%20retrospective%20review%20of%20LVAD%20implantation%20procedures%2C%20we%20examined%20the%20effect%20of%20time%20off%20anticoagulation%20on%20thrombosis%20and%20mortality%20rates%20after%20implantation.%20An%20international%20normalized%20ratio%5Cu2009%5Cu2264%5Cu20091.5%20was%20used%20to%20screen%20for%20patients%20taken%20off%20anticoagulation.%20Patients%20were%20divided%20into%20three%20groups%20by%20the%20cumulative%20number%20of%20days%20off%20anticoagulation%3A%20no%20discontinuation%2C%20short-term%20discontinuation%20%28%26lt%3B%5Cu200930%5Cu00a0days%29%2C%20and%20long-term%20discontinuation%20%28%5Cu2265%5Cu200930%5Cu00a0days%29.%20Rates%20of%20ischemic%20stroke%2C%20pump%20thrombosis%2C%20and%20mortality%20were%20compared%20among%20groups.%20Of%20245%20patients%20who%20underwent%20LVAD%20implantation%20during%20the%20study%2C%2070%20%2828.6%25%29%20were%20off%20anticoagulation%20during%20follow-up%3A%2037%20%2815.1%25%29%20had%20short-term%20discontinuation%20%28median%2C%2011%5Cu00a0days%29%2C%20and%2033%20%2813.5%25%29%20had%20long-term%20discontinuation%20%28median%2C%20124%5Cu00a0days%29.%20Patients%20with%20long-term%20discontinuation%20had%20a%20higher%20rate%20of%20ischemic%20stroke%20%28adjusted%20hazard%20ratio%208.5%2C%20p%5Cu2009%3D%5Cu20090.001%29%20and%20death%20%28adjusted%20hazard%20ratio%203.9%2C%20p%5Cu2009%3D%5Cu20090.001%29.%20The%20three%20groups%20did%20not%20differ%20in%20pump%20thrombosis%20rate.%20We%20conclude%20that%20after%20LVAD%20implantation%2C%20discontinuing%20anticoagulation%20for%5Cu2009%5Cu2265%5Cu200930%5Cu00a0days%20is%20independently%20associated%20with%20an%20increased%20risk%20of%20ischemic%20stroke%20and%20death.%22%2C%22date%22%3A%22Oct%2008%2C%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10047-022-01367-8%22%2C%22ISSN%22%3A%221619-0904%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229FBUJBMU%22%2C%22S7WF6DG3%22%2C%22WS63FIXU%22%2C%22ZMAN8MMI%22%2C%22VCK5HVUS%22%2C%22C2VFJYPK%22%2C%22MDTREPAF%22%5D%2C%22dateModified%22%3A%222022-11-04T15%3A28%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22TL2AQYCP%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Akkanti%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAkkanti%2C%20B.%2C%20Suarez%2C%20E.%20E.%2C%20O%26%23x2019%3BNeil%2C%20E.%20R.%20et%20al.%20%282022%29.%20Extracorporeal%20membrane%20oxygenation%20for%20COVID-19%3A%20Collaborative%20experience%20from%20the%20Texas%20Medical%20Center%20in%20Houston%20with%202%20years%20follow-up.%20%26lt%3Bi%26gt%3BASAIO%20J%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMAT.0000000000001791%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMAT.0000000000001791%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extracorporeal%20membrane%20oxygenation%20for%20COVID-19%3A%20Collaborative%20experience%20from%20the%20Texas%20Medical%20Center%20in%20Houston%20with%202%20years%20follow-up%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bindu%22%2C%22lastName%22%3A%22Akkanti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%20E.%22%2C%22lastName%22%3A%22Suarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%20R.%22%2C%22lastName%22%3A%22O%27Neil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aniket%20S.%22%2C%22lastName%22%3A%22Rali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rahat%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kha%22%2C%22lastName%22%3A%22Dinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Divina%20M.%22%2C%22lastName%22%3A%22Tuazon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20E.%22%2C%22lastName%22%3A%22MacGillivray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20L.%22%2C%22lastName%22%3A%22Diaz-Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leo%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joggy%20K.%22%2C%22lastName%22%3A%22George%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Biswajit%22%2C%22lastName%22%3A%22Kar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Patrick%20Herlihy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Igor%20D.%22%2C%22lastName%22%3A%22Gregoric%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faisal%22%2C%22lastName%22%3A%22Masud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%5D%2C%22abstractNote%22%3A%22Patients%20with%20severe%20refractory%20hypoxemic%20respiratory%20failure%20may%20benefit%20from%20extracorporeal%20membrane%20oxygenation%20%28ECMO%29%20for%20salvage%20therapy.%20The%20Coronavirus%20disease%202019%20%28COVID-19%29%20pandemic%20offered%20three%20high-volume%20independent%20ECMO%20programs%20at%20a%20large%20medical%20center%20the%20chance%20to%20collaborate%20to%20optimize%20ECMO%20care%20at%20the%20beginning%20of%20the%20pandemic%20in%20Spring%202020.%20Between%20March%2015%2C%202020%2C%20and%20May%2030%2C%202020%2C%203%2C615%20inpatients%20with%20COVID-19%20were%20treated%20at%20the%20Texas%20Medical%20Center.%20During%20this%20time%2C%2035%20COVID-19%20patients%20were%20cannulated%20for%20ECMO%2C%20all%20but%20one%20in%20a%20veno-venous%20configuration.%20At%20hospital%20discharge%2C%2023%20%2866%25%29%20of%20the%2035%20patients%20were%20alive.%20Twelve%20patients%20died%20of%20vasodilatory%20shock%20%28n%20%3D%209%29%2C%20intracranial%20hemorrhage%20%28n%20%3D%202%29%2C%20and%20cannulation-related%20bleeding%20and%20multiorgan%20dysfunction%20%28n%20%3D%201%29.%20The%20average%20duration%20of%20ECMO%20was%2013.6%20days%20in%20survivors%20and%2025.0%20days%20in%20nonsurvivors%20%28p%20%26lt%3B%200.04%29.%20At%201%20year%20follow-up%2C%20all%2023%20discharged%20patients%20were%20still%20alive%2C%20making%20the%201%20year%20survival%20rate%2066%25%20%2823%5C%2F35%29.%20At%202%20years%20follow-up%2C%20the%20overall%20rate%20of%20survival%20was%2063%25%20%2822%5C%2F35%29.%20Of%20those%20patients%20who%20survived%202%20years%2C%20all%20were%20at%20home%20and%20alive%20and%20well%20at%20follow-up.%22%2C%22date%22%3A%22Sept%2023%2C%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FMAT.0000000000001791%22%2C%22ISSN%22%3A%221538-943X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22AAQ89W3S%22%2C%22WS63FIXU%22%2C%22ZMAN8MMI%22%2C%22BQPL6CIB%22%2C%22VCK5HVUS%22%2C%22MDTREPAF%22%5D%2C%22dateModified%22%3A%222022-11-04T15%3A25%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22YH7QD3K8%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chatterjee%20et%20al.%22%2C%22parsedDate%22%3A%222022-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BChatterjee%2C%20S.%2C%20Loor%2C%20G.%2C%20%26lt%3Bstrong%26gt%3BShafii%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20E.%20et%20al.%20%282022%29.%20Commentary%3A%20Get%20up%20and%20go%21%20Pushing%20the%20envelope%20in%20ambulatory%20extracorporeal%20membrane%20oxygenation.%20%26lt%3Bi%26gt%3BJTCVS%20Tech%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%2C%20135%26%23x2013%3B136.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xjtc.2022.04.001%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xjtc.2022.04.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Commentary%3A%20Get%20up%20and%20go%21%20Pushing%20the%20envelope%20in%20ambulatory%20extracorporeal%20membrane%20oxygenation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20K.%22%2C%22lastName%22%3A%22Liao%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22June%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.xjtc.2022.04.001%22%2C%22ISSN%22%3A%222666-2507%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GNSKWJNU%22%2C%22ZMAN8MMI%22%2C%22VCK5HVUS%22%2C%22C2VFJYPK%22%2C%22ZSY78DJL%22%5D%2C%22dateModified%22%3A%222022-07-06T19%3A08%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22VUJA6IFM%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lamba%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLamba%2C%20H.%20K.%2C%20Parikh%2C%20U.%20M.%2C%20Vincent%2C%20J.%20et%20al.%20%282022%29.%20Preoperative%20hyponatremia%20and%20survival%20after%20left%20ventricular%20assist%20device%20implantation.%20%26lt%3Bi%26gt%3BArtif%20Organs%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faor.14280%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Faor.14280%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preoperative%20hyponatremia%20and%20survival%20after%20left%20ventricular%20assist%20device%20implantation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harveen%20K.%22%2C%22lastName%22%3A%22Lamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Umang%20M.%22%2C%22lastName%22%3A%22Parikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%22%2C%22lastName%22%3A%22Vincent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20B.%22%2C%22lastName%22%3A%22Civitello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajith%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anju%22%2C%22lastName%22%3A%22Bhardwaj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mourad%20H.%22%2C%22lastName%22%3A%22Senussi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20K.%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Hyponatremia%20is%20associated%20with%20adverse%20outcomes%20in%20heart%20failure%20and%20after%20cardiac%20surgery.%20We%20hypothesized%20that%20hyponatremia%20is%20associated%20with%20poorer%20short-term%20and%20longer%20term%20survival%20in%20patients%20after%20continuous-flow%20left%20ventricular%20assist%20device%20%28CF-LVAD%29%20placement.%5CnMETHODS%3A%20We%20reviewed%20a%20single-center%20database%20of%20patients%20who%20received%20a%20CF-LVAD%20during%202012-2017.%20Sodium%20%28Na%29%20values%20obtained%20within%2014%5Cu2009days%20before%20CF-LVAD%20insertion%20were%20averaged%3B%20patients%20%28n%5Cu00a0%3D%5Cu00a0332%29%20were%20divided%20into%20hyponatremia%20%28mean%20Na%20%26lt%3B135%5Cu2009mEq%5C%2FL%3B%20n%5Cu00a0%3D%5Cu00a0160%3B%2048.2%25%29%20and%20normonatremia%20groups%20%28mean%20Na%20135-145%5Cu2009mEq%5C%2FL%3B%20n%5Cu00a0%3D%5Cu00a0172%3B%2051.8%25%29.%20Patients%20requiring%20preoperative%20dialysis%20or%20pump%20exchange%20were%20excluded.%20We%20compared%20outcomes%20between%20preoperative%20hyponatremia%20and%20normonatremia%20groups.%5CnRESULTS%3A%20The%20two%20groups%26%23039%3B%20baseline%20characteristics%20were%20similar%2C%20although%20hyponatremia%20patients%20more%20often%20had%20preoperative%20mechanical%20circulatory%20support%20%2844.4%25%20vs.%2031.4%25%2C%20p%5Cu00a0%3D%5Cu00a00.002%29.%20Although%20hyponatremic%20and%20normonatremic%20patients%20did%20not%20differ%20in%2030-day%20mortality%20%287.5%25%20vs.%206.5%25%2C%20p%5Cu00a0%3D%5Cu00a00.7%29%2C%20preoperative%20hyponatremia%20was%20associated%20with%20greater%205-year%20mortality%20%2861%25%20vs.%2044%25%2C%20p%5Cu00a0%3D%5Cu00a00.03%29.%20On%20binary%20logistic%20regression%20analysis%2C%20the%20strongest%20independent%20predictors%20of%20late%20mortality%20were%20hyponatremia%20%28odds%20ratio%20%5BOR%5D%201.88%2C%2095%25%20CI%20%5B1.07-3.31%5D%2C%20p%5Cu00a0%3D%5Cu00a00.02%29%2C%20older%20age%20%28OR%201.03%2C%2095%25%20CI%20%5B1.01-1.05%5D%2C%20p%5Cu00a0%3D%5Cu00a00.01%29%2C%20and%20elevated%20mean%20right%20atrial%20pressure%5C%2Fpulmonary%20capillary%20wedge%20pressure%20ratio%20%28OR%204.69%2C%2095%25%20CI%20%5B1.76-12.47%5D%2C%20p%5Cu00a0%3D%5Cu00a00.002%29.%5CnCONCLUSIONS%3A%20Hyponatremia%20was%20not%20associated%20with%20greater%20early%20mortality%20but%20was%20associated%20with%20poorer%20late%20survival.%20The%20optimal%20timing%20of%20LVAD%20implantation%20in%20relation%20to%20hyponatremia%2C%20and%20whether%20correcting%20hyponatremia%20perioperatively%20improves%20long-term%20survival%2C%20should%20be%20investigated.%22%2C%22date%22%3A%22May%2007%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Faor.14280%22%2C%22ISSN%22%3A%221525-1594%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229FBUJBMU%22%2C%22GNSKWJNU%22%2C%22S7WF6DG3%22%2C%22ZMAN8MMI%22%2C%22VCK5HVUS%22%2C%22C2VFJYPK%22%2C%22V4E2TPM3%22%5D%2C%22dateModified%22%3A%222022-05-27T18%3A58%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22P79ZGHMF%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shafii%20et%20al.%22%2C%22parsedDate%22%3A%222021-12-07%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BShafii%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%2C%20Liao%2C%20K.%20and%20Ghanta%2C%20R.%20K.%20%282021%29.%20Commentary%3A%20Guidance%20during%20uncertain%20times%3A%20Navigating%20the%20HeartWare%20HVAD%20recall.%20%26lt%3Bi%26gt%3BJ%20Thorac%20Cardiovasc%20Surg%26lt%3B%5C%2Fi%26gt%3B%2C%20S0022-5223%2821%2901710%26%23x2013%3B4.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jtcvs.2021.12.003%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jtcvs.2021.12.003%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Commentary%3A%20Guidance%20during%20uncertain%20times%3A%20Navigating%20the%20HeartWare%20HVAD%20recall%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravi%20K.%22%2C%22lastName%22%3A%22Ghanta%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Dec%207%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jtcvs.2021.12.003%22%2C%22ISSN%22%3A%221097-685X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22ZMAN8MMI%22%2C%22AFDZBLNB%22%2C%22C2VFJYPK%22%2C%22AUPQENLZ%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A19%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22AVIZVEZ4%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loor%20et%20al.%22%2C%22parsedDate%22%3A%222021-12%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLoor%2C%20G.%2C%20Chatterjee%2C%20S.%20and%20%26lt%3Bstrong%26gt%3BShafii%26lt%3B%5C%2Fstrong%26gt%3B%2C%20A.%20%282021%29.%20Extracorporeal%20membrane%20oxygenation%20support%20before%20lung%20transplant%3A%20A%20bridge%20over%20troubled%20water.%20%26lt%3Bi%26gt%3BJTCVS%20Open%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B8%26lt%3B%5C%2Fi%26gt%3B%2C%20147%26%23x2013%3B154.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xjon.2021.10.011%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xjon.2021.10.011%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extracorporeal%20membrane%20oxygenation%20support%20before%20lung%20transplant%3A%20A%20bridge%20over%20troubled%20water%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Shafii%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Dec%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.xjon.2021.10.011%22%2C%22ISSN%22%3A%222666-2736%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GNSKWJNU%22%2C%22ZMAN8MMI%22%2C%22VCK5HVUS%22%2C%22C27MTI39%22%5D%2C%22dateModified%22%3A%222022-10-05T15%3A45%3A07Z%22%7D%7D%2C%7B%22key%22%3A%226L9HPKBG%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parikh%20et%20al.%22%2C%22parsedDate%22%3A%222021-06%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BParikh%2C%20U.%2C%20Lamba%2C%20H.%2C%20Ajmal%2C%20M.%20et%20al.%20%282021%29.%20Predictors%20of%20renal%20replacement%20therapy%20in%20patients%20with%20continuous%20flow%20left%20ventricular%20assist%20devices.%20%26lt%3Bi%26gt%3BJ%20Artif%20Organs%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%2C%20207%26%23x2013%3B216.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-020-01239-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-020-01239-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Predictors%20of%20renal%20replacement%20therapy%20in%20patients%20with%20continuous%20flow%20left%20ventricular%20assist%20devices%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Umang%22%2C%22lastName%22%3A%22Parikh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harveen%22%2C%22lastName%22%3A%22Lamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%22%2C%22lastName%22%3A%22Ajmal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%22%2C%22lastName%22%3A%22Vincent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carl%22%2C%22lastName%22%3A%22Walther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajith%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Civitello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%5D%2C%22abstractNote%22%3A%22Renal%20replacement%20therapy%20%28RRT%29%20after%20continuous%20flow%20left%20ventricular%20assist%20device%20%28CF-LVAD%29%20implantation%20significantly%20affects%20patients%26%23039%3B%20quality%20of%20life%20and%20survival.%20To%20identify%20preoperative%20prognostic%20markers%20in%20patients%20requiring%20RRT%20after%20CF-LVAD%20implantation%2C%20we%20retrospectively%20reviewed%20data%20from%20patients%20who%20underwent%20implantation%20of%20a%20CF-LVAD%20at%20our%20institution%20during%202012-2017.%20Patients%20who%20required%20preoperative%20RRT%20were%20excluded.%20Preoperative%20and%20operative%20characteristics%2C%20as%20well%20as%20survival%20and%20adverse%20events%2C%20were%20compared%20between%2074%20%2822.2%25%29%20patients%20requiring%20any%20duration%20of%20postoperative%20RRT%20and%20259%20%2877.8%25%29%20not%20requiring%20RRT.%20Patients%20requiring%20RRT%20experienced%20more%20postoperative%20complications%20than%20patients%20who%20did%20not%2C%20including%20respiratory%20failure%20necessitating%20tracheostomy%20%2835.7%25%20vs%202.5%25%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29%2C%20reoperation%20for%20bleeding%20%2834.3%25%20vs%2011.7%25%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29%2C%20and%20right%20heart%20failure%20necessitating%20perioperative%20mechanical%20circulatory%20support%20%2832.4%25%20vs%206.9%25%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29.%20Patients%20requiring%20postoperative%20RRT%20also%20had%20poorer%20survival%20at%2030%5Cu00a0days%20%2874.7%25%20vs%2098.8%25%29%2C%206%5Cu00a0months%20%2848.2%25%20vs%2095.1%25%29%2C%20and%2012%5Cu00a0months%20%2845.3%25%20vs%2090.2%25%29%20%28p%5Cu2009%26lt%3B%5Cu20090.001%29.%20Significant%20predictors%20of%20RRT%20after%20CF-LVAD%20implantation%20included%20urine%20proteinuria%20%28odds%20ratio%20%5BOR%5D%203.6%2C%2095%25%20confidence%20interval%20%5BCI%5D%20%5B1.7-7.6%5D%2C%20p%5Cu2009%3D%5Cu20090.001%29%2C%20estimated%20glomerular%20filtration%20rate%5Cu2009%26lt%3B%5Cu200945%5Cu00a0mL%5C%2Fmin%5C%2F1.73%5Cu00a0m2%20%28OR%203.4%2C%2095%25%20CI%20%5B1.5-17.8%5D%2C%20p%5Cu2009%3D%5Cu20090.004%29%2C%20and%20mean%20right%20atrial%20pressure%20to%20pulmonary%20capillary%20wedge%20pressure%20ratio%5Cu2009%5Cu2265%5Cu20090.54%20%28OR%202.6%2C%2095%25%20CI%20%5B1.3-5.%5D%2C%20p%5Cu2009%3D%5Cu20090.01%29.%20Of%20the%2074%20RRT%20patients%2C%2011%20%2814.9%25%29%20recovered%20renal%20function%20before%20discharge%2C%2036%20%2848.6%25%29%20still%20required%20RRT%20after%20discharge%2C%20and%2027%20%2836.5%25%29%20died%20before%20discharge.%20We%20conclude%20that%20preoperative%20renal%20and%20right%20ventricular%20dysfunction%20significantly%20predict%20postoperative%20renal%20failure%20and%20mortality%20after%20CF-LVAD%20implantation.%22%2C%22date%22%3A%22Jun%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10047-020-01239-z%22%2C%22ISSN%22%3A%221619-0904%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229FBUJBMU%22%2C%22S7WF6DG3%22%2C%22ZMAN8MMI%22%2C%22VCK5HVUS%22%2C%22C2VFJYPK%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A19%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22B5JFKIY7%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lamba%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLamba%2C%20H.%20K.%2C%20Kim%2C%20M.%2C%20Santiago%2C%20A.%20et%20al.%20%282021%29.%20Extracorporeal%20membrane%20oxygenation%20as%20a%20bridge%20to%20durable%20left%20ventricular%20assist%20device%20implantation%20in%20INTERMACS-1%20patients.%20%26lt%3Bi%26gt%3BJ%20Artif%20Organs%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-021-01275-3%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10047-021-01275-3%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extracorporeal%20membrane%20oxygenation%20as%20a%20bridge%20to%20durable%20left%20ventricular%20assist%20device%20implantation%20in%20INTERMACS-1%20patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harveen%20K.%22%2C%22lastName%22%3A%22Lamba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adriana%22%2C%22lastName%22%3A%22Santiago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Hudson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20B.%22%2C%22lastName%22%3A%22Civitello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajith%20P.%22%2C%22lastName%22%3A%22Nair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriel%22%2C%22lastName%22%3A%22Loor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexis%20E.%22%2C%22lastName%22%3A%22Shafii%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20K.%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Subhasis%22%2C%22lastName%22%3A%22Chatterjee%22%7D%5D%2C%22abstractNote%22%3A%22Left%20ventricular%20assist%20devices%20%28LVADs%29%20are%20increasingly%20used%20as%20destination%20therapy%20or%20as%20a%20bridge%20to%20future%20cardiac%20transplant%20in%20patients%20with%20end-stage%20heart%20failure.%20Extracorporeal%20membrane%20oxygenation%20%28ECMO%29%20can%20be%20used%20to%20bridge%20patients%20in%20cardiogenic%20shock%20or%20with%20decompensated%20heart%20failure%20to%20durable%20mechanical%20circulatory%20support.%20We%20assessed%20outcomes%20in%20patients%20in%20critical%20cardiogenic%20shock%20%28Interagency%20Registry%20for%20Mechanically%20Assisted%20Circulatory%20Support%20%5BINTERMACS%5D%20profile%201%29%20who%20underwent%20implantation%20of%20a%20continuous-flow%20%28CF%29-LVAD%2C%20with%20or%20without%20preoperative%20ECMO%20bridging.%20For%20this%20retrospective%20study%2C%20we%20selected%20INTERMACS%20profile%201%20patients%20who%20underwent%20CF-LVAD%20implantation%20at%20our%20institution%20between%20Sep%201%2C%202004%20and%20Nov%2030%2C%202018.%20Of%20768%20patients%20identified%2C%20133%20%2817.3%25%29%20were%20INTERMACS%20profile%201%3B%2026%20%2819.5%25%29%20received%20preoperative%20ECMO%20support%2C%20and%20107%20%2880.5%25%29%20did%20not.%20Postimplantation%20outcomes%20were%20compared%20between%20the%20ECMO%20and%20no-ECMO%20groups.%20No%20significant%20differences%20were%20found%20in%2030-day%20mortality%20%2815.4%20vs.%2015.9%25%2C%20P%5Cu2009%3D%5Cu20090.95%29%20or%20survival%20at%201%20year%20%2853.8%20vs.%2060.9%25%2C%20P%5Cu2009%3D%5Cu20090.51%29.%20Three%20patients%20who%20received%20ECMO%20before%20CF-LVAD%20implantation%20subsequently%20underwent%20cardiac%20transplant.%20In%20the%20ECMO%20group%2C%20the%20lactate%20level%201%20day%20after%20ECMO%20initiation%20was%20lower%20in%20survivors%20than%20nonsurvivors%20%282.7%5Cu2009%5Cu00b1%5Cu20092.2%20vs.%207.4%5Cu2009%5Cu00b1%5Cu20094.2%20mmol%5C%2FL%2C%20P%5Cu2009%3D%5Cu20090.02%3B%20area%20under%20the%20curve%5Cu2009%3D%5Cu20090.85%2C%20P%5Cu2009%3D%5Cu20090.01%29%20after%20CF-LVAD%20implantation.%20Bridging%20with%20ECMO%20to%20CF-LVAD%20implantation%20in%20carefully%20selected%20INTERMACS%20profile%201%20patients%20%28those%20who%20are%20at%20the%20highest%20risk%20for%20critical%20cardiogenic%20shock%20and%20for%20whom%20palliation%20may%20be%20the%20only%20other%20option%29%20produced%20acceptable%20postoperative%20outcomes.Field%20of%20research%3A%20Artificial%20lung%5C%2FECMO.%22%2C%22date%22%3A%22May%2013%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10047-021-01275-3%22%2C%22ISSN%22%3A%221619-0904%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%229FBUJBMU%22%2C%22GNSKWJNU%22%2C%22S7WF6DG3%22%2C%22ZMAN8MMI%22%5D%2C%22dateModified%22%3A%222021-06-08T17%3A07%3A48Z%22%7D%7D%5D%7D
Ali, A., Gray, Z., Loor, G. et al. (2024). Minimally Invasive Mitral Valve Surgery Using a Cold Fibrillatory Cardiac Arrest Technique in Patients With Prior Cardiac Surgery. Texas Heart Institute Journal 51, e238167. https://doi.org/10.14503/THIJ-23-8167.
Allen, S. R., Slaughter, M. S., Ahmed, M. M. et al. (2022). COMPETENCE Trial: The EVAHEART 2 continuous flow left ventricular assist device. J Heart Lung Transplant, S1053-2498(22)02180–5. https://doi.org/10.1016/j.healun.2022.10.011.
Inchaustegui, C. A., Patel, A., Lamba, H. K. et al. (2022). Impact of time off anticoagulation in patients with continuous-flow left ventricular assist devices. J Artif Organs. https://doi.org/10.1007/s10047-022-01367-8.
Akkanti, B., Suarez, E. E., O’Neil, E. R. et al. (2022). Extracorporeal membrane oxygenation for COVID-19: Collaborative experience from the Texas Medical Center in Houston with 2 years follow-up. ASAIO J. https://doi.org/10.1097/MAT.0000000000001791.
Chatterjee, S., Loor, G., Shafii, A. E. et al. (2022). Commentary: Get up and go! Pushing the envelope in ambulatory extracorporeal membrane oxygenation. JTCVS Tech 13, 135–136. https://doi.org/10.1016/j.xjtc.2022.04.001.
Lamba, H. K., Parikh, U. M., Vincent, J. et al. (2022). Preoperative hyponatremia and survival after left ventricular assist device implantation. Artif Organs. https://doi.org/10.1111/aor.14280.
Shafii, A., Liao, K. and Ghanta, R. K. (2021). Commentary: Guidance during uncertain times: Navigating the HeartWare HVAD recall. J Thorac Cardiovasc Surg, S0022-5223(21)01710–4. https://doi.org/10.1016/j.jtcvs.2021.12.003.
Loor, G., Chatterjee, S. and Shafii, A. (2021). Extracorporeal membrane oxygenation support before lung transplant: A bridge over troubled water. JTCVS Open 8, 147–154. https://doi.org/10.1016/j.xjon.2021.10.011.
Parikh, U., Lamba, H., Ajmal, M. et al. (2021). Predictors of renal replacement therapy in patients with continuous flow left ventricular assist devices. J Artif Organs 24, 207–216. https://doi.org/10.1007/s10047-020-01239-z.
Lamba, H. K., Kim, M., Santiago, A. et al. (2021). Extracorporeal membrane oxygenation as a bridge to durable left ventricular assist device implantation in INTERMACS-1 patients. J Artif Organs. https://doi.org/10.1007/s10047-021-01275-3.

Recent News

See All

The Texas Heart Institute Provides BiVACOR® Total Artificial Heart Patient Update

Successful first-in-human bridge to heart transplant with revolutionary valveless artificial heart Houston, Texas, July 26, 2024 – The Texas Heart...

Read more

The Texas Heart Institute Makes a Strong Showing at ISHLT 2023

Daniel Timms, PhD, founder and chief technical officer of BiVACOR, Inc., described the benchtop testing and preclinical studies performed with...

Read more

Sharing Our Latest Research With the World

Our Professional Staff members have demonstrated a commitment to advancing cardiovascular science. This can be seen in their research output....

Read more