José Díez, MD

Dr. José G. Díez is board certified in cardiovascular diseases and interventional cardiology. He serves as senior research scientist in interventional cardiology at The Texas Heart Institute at CHI Baylor St Luke’s Medical Center (BSLMC) and clinical associate professor of medicine at Baylor College of Medicine in Houston, Texas.

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He is on the interventional cardiology professional staff at THI at BSLMC and the consulting staff of the cardiology service at the Texas Children’s Hospital in Houston. Dr. Díez is also an associate editor of The Texas Heart Institute Journal. A graduate of Javeriana University in Bogotá, Colombia, Dr. Díez completed an internal medicine residency at the same institution and another at Boston University in Massachusetts.

Dr. Díez completed his training in cardiovascular diseases and interventional cardiology at The Texas Heart Institute at St. Luke’s Episcopal Hospital, where he served as chief fellow. His previous academic experience includes appointments at Baylor College of Medicine as director of invasive cardiology at the Baylor Heart Clinic and director of interventional cardiology research.

At Tulane University School of Medicine in New Orleans, Louisiana, he served as director of clinical and interventional research and co-director of the cardiovascular catheterization laboratories. He has received research and education awards from the Mueller Foundation, the EVEREST program, the American College of Cardiology, and the American Heart Association.

His interests include acute coronary syndromes; acute and chronic aortic syndromes (aortic aneurysms, aortic dissection, Marfan syndrome); valvular disease (with a focus on the aortic valve and new therapies, such as transcatheter aortic valve implantation TAVI/TAVR); atherothrombosis; antiplatelet and antithrombin therapy; interventional strategies and devices; and vascular biology. Dr. Díez is fluent in both English and Spanish. He is currently accepting new patients, including those seeking to begin cardiovascular care and treatment and those seeking secondary opinions and consultations.

See Publications

Texas Heart Institute Positions

  • Teaching Staff, Cardiovascular Disease Fellowship
  • Associate Editor, Texas Heart Institute Journal

Interests

  • Interventional cardiology
  • acute coronary syndromes
  • antiplatelet and antithrombin therapies

Education

  • Medical School:

    Pontifical Xavierian University

  • Residency:

    Caritas Carney Hospital

  • Fellowships:

    Baylor College of Medicine

Academic & Clinical Affiliations

  • Baylor College of Medicine
  • Baylor St. Luke's Medical Center
  • Texas Children's Hospital
  • Park Plaza Hospital
  • Hall-Garcia Cardiology at Baylor College of Medicine

Certifications

  • Cardiovascular Disease, American Board of Internal Medicine
  • Interventional Cardiology, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine

Honors, Awards and Memberships

Publications

4862227 YL3LPZGE 1 alternatives-to-animal-experimentation 10 date desc 1887 https://www.texasheart.org/wp-content/plugins/zotpress/
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Hong, J. C., Orozco-Sevilla, V., Diez, J. G. et al. (2023). Transcatheter aortic valve-in-valve-in-valve replacement in a young woman with transcatheter structural valve deterioration within a degenerated aortic root homograft. Tex Heart Inst J 50, e227874. https://doi.org/10.14503/THIJ-22-7874.
Farmer, D. M., Díez, J. G., Orozco-Sevilla, V. et al. (2022). Use of a self-expanding transcatheter valve for a degenerated INTUITY valve. J Card Surg. https://doi.org/10.1111/jocs.16746.
Kherallah, R. Y., Koneru, S., Krajcer, Z. et al. (2021). Hemodynamic outcomes after valve-in-valve transcatheter aortic valve replacement: a single-center experience. Ann Cardiothorac Surg 10, 630–640. https://doi.org/10.21037/acs-2021-tviv-131.
Cekmecelioglu, D., Preventza, O., Dougherty, K. G. et al. (2021). Transcatheter valve-in-valve implantation for degenerated stentless aortic bioroots. Ann Cardiothorac Surg 10, 641–650. https://doi.org/10.21037/acs-2021-tviv-124.
Kleiman, N. S., Maini, B. J., Reardon, M. J. et al. (2016). Neurological events following transcatheter aortic valve replacement and their predictors: a report from the corevalve trials. Circ Cardiovasc Interv 9. https://doi.org/10.1161/CIRCINTERVENTIONS.115.003551.
Díez, J. G., Schechter, M., Dougherty, K. G. et al. (2016). Transcatheter aortic valve-in-valve replacement instead of a 4th sternotomy in a 21-year-old woman with aortic homograft failure. Tex Heart Inst J 43, 334–337. https://doi.org/10.14503/THIJ-15-5128.
Yakubov, S. J., Adams, D. H., Watson, D. R. et al. (2015). 2-Year Outcomes After Iliofemoral Self-Expanding Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis Deemed Extreme Risk for Surgery. J Am Coll Cardiol 66, 1327–1334. https://doi.org/10.1016/j.jacc.2015.07.042.
Lombo, B., Alkhalil, I., Golden, M. P. et al. (2015). Prevalence of metabolic syndrome in patients with HIV in the era of highly active antiretroviral therapy. Conn Med 79, 277–281
Popma, J. J., Adams, D. H., Reardon, M. J. et al. (2014). Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol 63, 1972–1981. https://doi.org/10.1016/j.jacc.2014.02.556.
Weeks, P. A., Alkhateeb, H. M., Michaud, S. E. et al. (2013). Evaluation of bivalirudin hyper- and hypo-ACT responses in the setting of percutaneous coronary intervention. J Invasive Cardiol 25, 250–253