Feng Gao, MD
See Publications

Texas Heart Institute Positions

Education

  • Undergraduate:

    The University of Texas at Austin

  • Medical School:

    The University of Texas Southwestern Medical School

  • Residency:

    Baylor College of Medicine

Publications

4862227 FKNSPK49 1 alternatives-to-animal-experimentation 10 date desc Gao 53142 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2277U2UHFA%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gao%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-29%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%2C%20Kherallah%2C%20R.%2C%20Koetting%2C%20M.%20et%20al.%20%282023%29.%20Leadless%20pacemaker%20with%20transcatheter%20aortic%20valve%20implantation%3A%20A%20single-center%20experience.%20%26lt%3Bi%26gt%3BPacing%20Clin%20Electrophysiol%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.14702%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpace.14702%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Leadless%20pacemaker%20with%20transcatheter%20aortic%20valve%20implantation%3A%20A%20single-center%20experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Riyad%22%2C%22lastName%22%3A%22Kherallah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mackenzie%22%2C%22lastName%22%3A%22Koetting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leo%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Seger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srikanth%22%2C%22lastName%22%3A%22Koneru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Coselli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ourania%22%2C%22lastName%22%3A%22Preventza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vicente%22%2C%22lastName%22%3A%22Orozco-Sevilla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nastasya%22%2C%22lastName%22%3A%22Manon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20V.%22%2C%22lastName%22%3A%22Silva%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20safety%20and%20efficacy%20of%20leadless%20pacemakers%20%28LP%29%20in%20transcatheter%20aortic%20valve%20implant%20%28TAVI%29%20patients%20is%20not%20well%20known%20due%20to%20paucity%20of%20data.%20Herein%2C%20we%20compared%20outcomes%20between%20leadless%20pacemakers%20to%20traditional%20dual%20chamber%20pacemakers%20%28DCP%29%20following%20TAVI.%5CnMETHODS%3A%20A%20single-center%20retrospective%20study%20was%20conducted%2C%20including%20a%20total%20of%2027%20patients%20with%20LP%20and%2033%20patients%20with%20DCP%20after%20TAVI%20between%20November%202013%20and%20May%202021.%20We%20compared%20baseline%20demographics%2C%20pacemaker%20indications%2C%20complication%20rates%2C%20percent%20pacing%2C%20and%20ejection%20fractions.%5CnRESULTS%3A%20Leading%20indications%20for%20pacemaker%20implant%20were%20complete%20heart%20block%20%2874%25%20LP%2C%2073%25%20DCP%29%20and%20high%20degree%20atrioventricular%20block%20%2826%25%20LP%2C%2021%25%20DCP%29.%20Twenty-two%20%2882%25%29%20LP%20patients%20had%20devices%20implanted%20in%20the%20right%20ventricular%20septal-apex.%20Three%20%289%25%29%20DCP%20patients%20required%20rehospitalization%20for%20pocket%20related%20complications.%20Zero%20pacemaker-related%20mortality%20was%20observed%20in%20both%20groups.%20Frequency%20of%20ventricular%20pacing%20and%20ejection%20fraction%20was%20similar%20between%20LP%20and%20DCP%20groups.%5CnCONCLUSION%3A%20From%20this%20single-center%20retrospective%20study%2C%20LP%20implant%20was%20feasible%20following%20TAVI%20and%20was%20found%20to%20have%20comparable%20performance%20to%20DCPs.%20LPs%20may%20be%20a%20reasonable%20alternative%20in%20TAVI%20patients%20where%20single%20ventricular%20pacing%20is%20indicated.%20Larger%20studies%20are%20required%20to%20validate%20these%20findings.%22%2C%22date%22%3A%222023-04-29%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fpace.14702%22%2C%22ISSN%22%3A%221540-8159%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SQD2CTYV%22%2C%22BJSZ96GT%22%2C%22DJYFUK6T%22%2C%22AAQ89W3S%22%2C%222K4N54U2%22%2C%22KRWEJ8EU%22%2C%22MZXU6P62%22%2C%22NTAHPDUG%22%2C%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-21T18%3A44%3A29Z%22%7D%7D%2C%7B%22key%22%3A%229CB84GF2%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Potter%20et%20al.%22%2C%22parsedDate%22%3A%222022-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPotter%2C%20A.%20S.%2C%20Patel%2C%20A.%2C%20Khawaja%2C%20M.%20et%20al.%20%282022%29.%20Outcomes%20by%20Class%20of%20Anticoagulant%20Use%20for%20Nonvalvular%20Atrial%20Fibrillation%20in%20Patients%20With%20Active%20Cancer.%20%26lt%3Bi%26gt%3BJACC%20CardioOncol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%2C%20341%26%23x2013%3B350.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jaccao.2022.07.004%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jaccao.2022.07.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Outcomes%20by%20Class%20of%20Anticoagulant%20Use%20for%20Nonvalvular%20Atrial%20Fibrillation%20in%20Patients%20With%20Active%20Cancer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%20S.%22%2C%22lastName%22%3A%22Potter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ashley%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muzamil%22%2C%22lastName%22%3A%22Khawaja%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%22%2C%22lastName%22%3A%22Kaczmarek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaveh%22%2C%22lastName%22%3A%22Karimzad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juhee%22%2C%22lastName%22%3A%22Song%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Efstratios%22%2C%22lastName%22%3A%22Koutroumpakis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaden%22%2C%22lastName%22%3A%22Khalaf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cezar%22%2C%22lastName%22%3A%22Iliescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anita%22%2C%22lastName%22%3A%22Deswal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%20L.%22%2C%22lastName%22%3A%22Palaskas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20choice%20of%20anticoagulant%20agent%20for%20patients%20with%20nonvalvular%20atrial%20fibrillation%20%28NVAF%29%20in%20the%20setting%20of%20active%20cancer%20has%20not%20been%20well%20studied.%5CnOBJECTIVES%3A%20The%20aim%20of%20this%20study%20was%20to%20compare%20the%20rates%20of%20cerebrovascular%20accident%20%28CVA%29%2C%20gastrointestinal%20bleeding%20%28GIB%29%2C%20and%20intracranial%20hemorrhage%20%28ICH%29%20in%20patients%20treated%20with%20direct%20oral%20anticoagulant%20agents%20%28DOACs%29%20compared%20with%20warfarin%20for%20NVAF%20in%20patients%20with%20active%20cancer.%5CnMETHODS%3A%20This%20was%20a%20retrospective%20electronic%20medical%20record%20review%20of%20eligible%20patients%20treated%20at%20a%20cancer%20hospital.%20The%20outcome%20events%20were%20CVA%3B%20GIB%3B%20ICH%3B%20the%20composite%20of%20GIB%2C%20CVA%2C%20or%20ICH%3B%20and%20overall%20mortality.%20Propensity%20score%20matching%20%281%3A1%29%20was%20conducted%20to%20select%20comparable%20patients%20receiving%20warfarin%20vs%20DOACs.%20Fine-Gray%20models%20were%20fitted%20for%20each%20outcome%20event.%5CnRESULTS%3A%20The%20study%20cohort%20included%201%2C133%20patients%20%28mean%20age%2072%20%5Cu00b1%208.8%20years%2C%2042%25%20women%29%2C%20of%20whom%2074%25%20received%20DOACs%20%2857%25%20received%20apixaban%29.%20After%20propensity%20score%20matching%2C%20195%20patients%20were%20included%20in%20each%20anticoagulant%20agent%20group.%20When%20comparing%20warfarin%20with%20DOACs%2C%20there%20were%20similar%20risks%20for%20CVA%20%28subdistribution%20HR%3A%200.738%3B%2095%25%20CI%3A%200.334-1.629%29%3B%20ICH%20%28subdistribution%20HR%3A%200.295%3B%2095%25%20CI%3A%200.032-2.709%29%3B%20GIB%20%28subdistribution%20HR%3A%201.819%3B%2095%25%20CI%3A%200.774-4.277%29%3B%20and%20the%20composite%20of%20GIB%2C%20CVA%2C%20or%20ICH%20%28subdistribution%20HR%3A%201.151%3B%2095%25%20CI%3A%200.645-2.054%29.%5CnCONCLUSIONS%3A%20Patients%20with%20active%20cancer%20had%20similar%20risks%20for%20CVA%2C%20ICH%2C%20and%20GIB%20when%20treated%20with%20DOACs%20compared%20with%20warfarin%20for%20NVAF.%22%2C%22date%22%3A%222022-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jaccao.2022.07.004%22%2C%22ISSN%22%3A%222666-0873%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-02T02%3A56%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22FSLYNSH6%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gao%20and%20Rahman%22%2C%22parsedDate%22%3A%222022-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%20and%20Rahman%2C%20F.%20%282022%29.%20DOACs%20and%20Atherosclerotic%20Cardiovascular%20Disease%20Management%3A%20Can%20We%20Find%20the%20Right%20Balance%20Between%20Efficacy%20and%20Harm.%20%26lt%3Bi%26gt%3BCurr%20Atheroscler%20Rep%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B24%26lt%3B%5C%2Fi%26gt%3B%2C%20457%26%23x2013%3B469.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11883-022-01022-w%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11883-022-01022-w%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22DOACs%20and%20Atherosclerotic%20Cardiovascular%20Disease%20Management%3A%20Can%20We%20Find%20the%20Right%20Balance%20Between%20Efficacy%20and%20Harm%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Faisal%22%2C%22lastName%22%3A%22Rahman%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%20OF%20REVIEW%3A%20The%20balance%20between%20efficacy%20and%20harm%20remains%20a%20challenge%20in%20the%20adoption%20of%20non-vitamin%20K%20antagonist%20direct%20oral%20anticoagulants%20%28DOACs%29%20for%20secondary%20atherosclerotic%20disease%20prevention.%20We%20provide%20a%20comprehensive%20review%20of%20the%20evidence%20for%20and%20against%20the%20addition%20of%20DOACs%20to%20the%20current%20management%20of%20atherosclerotic%20cardiovascular%20disease%2C%20including%20stable%20coronary%20artery%20disease%20%28CAD%29%2C%20acute%20coronary%20syndrome%20%28ACS%29%2C%20peripheral%20artery%20disease%20%28PAD%29%2C%20and%20percutaneous%20coronary%20interventions%20%28PCI%29.%5CnRECENT%20FINDINGS%3A%20The%20DOAC%20class%20exerts%20pleiotropic%20effects%20on%20atherosclerotic%20progression%20through%20coagulation%20and%20inflammatory%20pathways.%20In%20ACS%2C%20low-dose%20DOAC%20provides%20no%20added%20efficacy%20in%20the%20setting%20of%20dual%20antiplatelet%20therapy%3B%20however%2C%20full-dose%20DOAC%20increases%20bleeding.%20Efficacy-safety%20profile%20favor%20use%20of%20low-dose%20rivaroxaban%20in%20select%20stable%20CAD%20or%20PAD%20patients.%20Atrial%20fibrillation%20patients%20undergoing%20PCI%20resort%20to%20dual%20therapy%20with%20DOAC%20due%20to%20prohibitory%20bleeding%20with%20triple%20anti-thrombotic%20therapy.%20Evidence%20favors%20DOAC%20use%20in%20CAD%20and%20PAD%3B%20however%2C%20careful%20individual%20considerations%20must%20be%20undertaken.%22%2C%22date%22%3A%222022-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11883-022-01022-w%22%2C%22ISSN%22%3A%221534-6242%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-06-29T20%3A17%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22A2VTRFWH%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gao%20et%20al.%22%2C%22parsedDate%22%3A%222022-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%2C%20Wahl%2C%20J.%20A.%20and%20Floyd%2C%20T.%20F.%20%282022%29.%20Anesthesia%20and%20neurotoxicity%20study%20design%2C%20execution%2C%20and%20reporting%20in%20the%20nonhuman%20primate%3A%20A%20systematic%20review.%20%26lt%3Bi%26gt%3BPaediatr%20Anaesth%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B32%26lt%3B%5C%2Fi%26gt%3B%2C%20509%26%23x2013%3B521.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpan.14401%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpan.14401%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Anesthesia%20and%20neurotoxicity%20study%20design%2C%20execution%2C%20and%20reporting%20in%20the%20nonhuman%20primate%3A%20A%20systematic%20review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20A.%22%2C%22lastName%22%3A%22Wahl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20F.%22%2C%22lastName%22%3A%22Floyd%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Concern%20for%20a%20role%20of%20anesthesia%20in%20neurotoxicity%20in%20children%20originated%20from%20neonatal%20rodent%20and%20nonhuman%20primate%20%28NHP%29%20models%2C%20yet%20prospective%20clinical%20studies%20have%20largely%20not%20supported%20this%20concern.%20The%20goal%20of%20this%20study%20was%20to%20conduct%20an%20objective%20assessment%20of%20published%20NHP%20study%20rigor%20in%20design%2C%20execution%2C%20and%20reporting.%5CnMETHODS%3A%20A%20MEDLINE%20search%20from%202005%20to%20December%202021%20was%20performed.%20Inclusion%20criteria%20included%20full-length%20original%20studies%20published%20in%20English%20under%20peer-reviewed%20journals.%20We%20documented%20experimental%20parameters%20on%20anesthetic%20dosing%2C%20monitoring%2C%20vitals%2C%20and%20experimental%20outcomes.%5CnRESULTS%3A%20Twenty-three%20manuscripts%20were%20included.%20Critical%20issues%20identified%20in%20study%20design%20included%3A%20lack%20of%20blinding%20in%20data%20acquisition%20%2857%25%29%20and%20analysis%20%28100%25%29%2C%20supratherapeutic%20%284-12%20fold%29%20maintenance%20dosing%20in%2022%25%20of%20studies%2C%20lack%20of%20sample%20size%20justification%20%2891%25%29%20resulting%20in%20a%20mean%20%28SD%29%20sample%20size%20of%206%20%283%29%20animals%20per%20group.%20Critical%20items%20identified%20in%20the%20conduct%20and%20reporting%20of%20studies%20included%3A%20documentation%20of%20anesthesia%20provider%20%280%25%29%2C%20electrocardiogram%20monitoring%20%2835%25%29%2C%20arterial%20monitoring%20%284%25%29%2C%20spontaneous%20ventilation%20employed%20%2835%25%29%2C%20failed%20intubations%20resulting%20in%20comingling%20ventilated%20and%20unventilated%20animals%20in%20data%20analysis%2C%20inaccurate%20reporting%20of%20failed%20intubation%2C%20and%20only%2050%25%20reporting%20on%20survival.%20Inconsistencies%20were%20noted%20in%20drug-related%20induction%20of%20neuroapoptosis%20and%20region%20of%20occurrence.%20Further%2C%2067%25-100%25%20of%20behavior%20outcomes%20were%20not%20significantly%20different%20from%20controls.%5CnCONCLUSIONS%3A%20Important%20deficits%20in%20study%20design%2C%20execution%2C%20and%20reporting%20were%20identified%20in%20neonatal%20NHP%20studies.%20These%20results%20raise%20concern%20for%20the%20validity%20and%20reliability%20of%20these%20studies%20and%20may%20explain%20in%20part%20the%20divergence%20from%20results%20obtained%20in%20human%20neonates.%22%2C%22date%22%3A%222022-04%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Fpan.14401%22%2C%22ISSN%22%3A%221460-9592%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-06-29T21%3A22%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22PUCDUTRC%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gao%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%2C%20Koh%2C%20S.%2C%20Taveras-Alam%2C%20S.%20et%20al.%20%282022%29.%20A%20Right%20Atrial%20Mass%20with%20Fever%20and%20Cutaneous%20Nodules.%20%26lt%3Bi%26gt%3BMethodist%20Debakey%20Cardiovasc%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B18%26lt%3B%5C%2Fi%26gt%3B%2C%2048%26%23x2013%3B53.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14797%5C%2Fmdcvj.1126%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14797%5C%2Fmdcvj.1126%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Right%20Atrial%20Mass%20with%20Fever%20and%20Cutaneous%20Nodules%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Koh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Taveras-Alam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Umair%22%2C%22lastName%22%3A%22Khalid%22%7D%5D%2C%22abstractNote%22%3A%22Primary%20cardiac%20tumors%2C%20although%20exceedingly%20rare%2C%20should%20be%20considered%20in%20the%20differential%20diagnosis%20during%20workup%20of%20any%20cardiac%20mass.%20Extranodal%20cardiac%20lymphomas%20have%20a%20natural%20aggressive%20course%20due%20to%20delayed%20diagnosis.%20We%20present%20a%2071-year-old%20male%20with%20a%20dual-chamber%20pacemaker%20who%20presented%20with%20fevers%20and%20new%20cutaneous%20nodules.%20He%20was%20found%20to%20have%20a%20right%20atrial%20primary%20anaplastic%20large-cell%20lymphoma%20and%20had%20a%20complete%20metabolic%20response%20after%20chemotherapy.%20Our%20case%20highlights%20the%20importance%20of%20a%20multimodality%20approach%20in%20the%20diagnosis%20of%20cardiac%20tumors%20and%20during%20follow-up%20after%20treatment.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14797%5C%2Fmdcvj.1126%22%2C%22ISSN%22%3A%221947-6108%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-06-29T21%3A22%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22BHFMT8L7%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gao%20and%20Khalid%22%2C%22parsedDate%22%3A%222021-11%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%20and%20Khalid%2C%20U.%20%282021%29.%20Inadvertent%20Septal%20Ablation%20During%20Percutaneous%20Coronary%20Intervention.%20%26lt%3Bi%26gt%3BCureus%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%2C%20e19227.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7759%5C%2Fcureus.19227%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7759%5C%2Fcureus.19227%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Inadvertent%20Septal%20Ablation%20During%20Percutaneous%20Coronary%20Intervention%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Umair%22%2C%22lastName%22%3A%22Khalid%22%7D%5D%2C%22abstractNote%22%3A%22We%20present%20a%20case%20of%20inadvertent%20occlusion%20of%20a%20septal%20artery%20from%20being%20jailed%20during%20percutaneous%20coronary%20intervention%20of%20left%20anterior%20descending%20artery.%20This%20resulted%20in%20partial%20loss%20of%20the%20interventricular%20septum.%20Risks%20of%20side%20branch%20occlusion%20and%20bifurcation%20stenting%20are%20discussed.%22%2C%22date%22%3A%222021-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7759%5C%2Fcureus.19227%22%2C%22ISSN%22%3A%222168-8184%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-06-29T21%3A22%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22FURV2CHA%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jia%20et%20al.%22%2C%22parsedDate%22%3A%222021-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJia%2C%20X.%2C%20%26lt%3Bstrong%26gt%3BGao%26lt%3B%5C%2Fstrong%26gt%3B%2C%20F.%2C%20Pickett%2C%20J.%20K.%20et%20al.%20%282021%29.%20Association%20between%20omega-3%20fatty%20acid%20treatment%20and%20atrial%20fibrillation%20in%20cardiovascular%20outcome%20trials%3A%20A%20systematic%20review%20and%20meta-analysis.%20%26lt%3Bi%26gt%3BCardiovasc%20Drugs%20Ther%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B35%26lt%3B%5C%2Fi%26gt%3B%2C%20793%26%23x2013%3B800.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10557-021-07204-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10557-021-07204-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20omega-3%20fatty%20acid%20treatment%20and%20atrial%20fibrillation%20in%20cardiovascular%20outcome%20trials%3A%20A%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoming%22%2C%22lastName%22%3A%22Jia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22June%20K.%22%2C%22lastName%22%3A%22Pickett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mahmoud%22%2C%22lastName%22%3A%22Al%20Rifai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yochai%22%2C%22lastName%22%3A%22Birnbaum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vijay%22%2C%22lastName%22%3A%22Nambi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salim%20S.%22%2C%22lastName%22%3A%22Virani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christie%20M.%22%2C%22lastName%22%3A%22Ballantyne%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20Data%20on%20the%20relationship%20between%20omega-3%20fatty%20acid%20%28n-3%20FA%29%20therapy%20with%20atrial%20fibrillation%20%28AF%29%20have%20been%20inconsistent.%20We%20investigate%20the%20association%20between%20n-3%20FA%20and%20risk%20for%20AF%20by%20pooling%20data%20from%20available%20large%2C%20cardiovascular%20outcome%20trials.%5CnMETHODS%3A%20We%20performed%20a%20systematic%20search%20on%20PubMed%20and%20Embase%20for%20studies%20on%20n-3%20FA%20with%20AF%20as%20an%20outcome%20measure.%20Large%20%28%5Cu2265%5Cu20091000%20participants%29%20randomized%20controlled%20trials%20with%5Cu2009%5Cu2265%5Cu20091-year%20follow-up%20period%20were%20included.%20The%20association%20between%20n-3%20FA%20and%20risk%20of%20AF%20or%20stroke%20was%20assessed.%20Mantel-Haenszel%20random%20effects%20model%20was%20used%20to%20calculate%20risk%20ratios%20%28RR%29%20with%2095%25%20confidence%20intervals%20%28CI%29.%20We%20then%20performed%20meta-regression%20to%20evaluate%20effect%20on%20AF%20by%20dose%20of%20n-3%20FA%20therapy.%5CnRESULTS%3A%20A%20total%20of%208%20randomized%20control%20trials%20encompassing%2083%2C112%20participants%20were%20included%20in%20the%20meta-analysis.%20Of%20these%2C%20five%20trials%20assessed%20a%20lower%20dose%20of%20n-3%20FA%20%28%5Cu2264%5Cu20091%5Cu00a0g%20daily%2C%20n%5Cu2009%3D%5Cu200961%2C096%29%20while%203%20trials%20assessed%20a%20higher%20dose%20%28%26gt%3B%5Cu20091%5Cu00a0g%20daily%2C%20n%5Cu2009%3D%5Cu200922%2C016%29.%20In%20meta-analysis%2C%20a%20significant%20association%20was%20noted%20between%20n-3%20FA%20treatment%20and%20risk%20of%20AF%20%284.0%25%20vs%203.3%25%3B%20RR%201.24%2C%2095%25%20CI%201.11-1.38%2C%20p%5Cu2009%3D%5Cu20090.0002%29.%20There%20was%20a%20modest%20but%20still%20significant%20association%20in%20the%20lower%5Cu00a0dose%20%28n-3%20FA%5Cu2009%5Cu2264%5Cu20091%5Cu00a0g%20daily%29%20sub-group%20%28RR%201.12%2C%2095%25%20CI%201.04-1.21%2C%20p%5Cu2009%3D%5Cu20090.004%29%20and%20stronger%20association%20in%20the%20higher%5Cu00a0dose%20%28n-3%20FA%5Cu2009%26gt%3B%5Cu20091%5Cu00a0g%20daily%29%20sub-group%20%28RR%201.51%2C%2095%25%20CI%201.26-1.80%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%3B%20p-interaction%20between%20low%20versus%20high%20subgroups%5Cu2009%3D%5Cu20090.003%29.%20There%20was%20no%20increase%20in%20stroke%20risk%20%28RR%201.04%2C%2095%25%20CI%200.90-1.20%29.%20Meta-regression%20demonstrated%20a%20significant%20association%20between%20dose%20of%20n-3%20FA%20with%20risk%20for%20AF%20events%20%28log%20RR%200.103%2C%2095%25%20CI%200.048-0.159%2C%20p%5Cu2009%26lt%3B%5Cu20090.001%29.%5CnCONCLUSION%3A%20While%20overall%20AF%20event%20rates%20were%20low%2C%20n-3%20FA%20treatment%20is%20associated%20with%20increased%20risk%20for%20AF.%22%2C%22date%22%3A%22Aug%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10557-021-07204-z%22%2C%22ISSN%22%3A%221573-7241%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22SIH54GGA%22%2C%22K4H4V8VZ%22%2C%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-21T18%3A44%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22AQLRVLKR%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Busch%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBusch%2C%20D.%20R.%2C%20Lin%2C%20W.%2C%20Goh%2C%20C.%20C.%20et%20al.%20%282021%29.%20Towards%20rapid%20intraoperative%20axial%20localization%20of%20spinal%20cord%20ischemia%20with%20epidural%20diffuse%20correlation%20monitoring.%20%26lt%3Bi%26gt%3BPLoS%20One%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B16%26lt%3B%5C%2Fi%26gt%3B%2C%20e0251271.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0251271%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0251271%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Towards%20rapid%20intraoperative%20axial%20localization%20of%20spinal%20cord%20ischemia%20with%20epidural%20diffuse%20correlation%20monitoring%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20R.%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chia%20Chieh%22%2C%22lastName%22%3A%22Goh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%22%2C%22lastName%22%3A%22Larson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Wahl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20V.%22%2C%22lastName%22%3A%22Bilfinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arjun%20G.%22%2C%22lastName%22%3A%22Yodh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20F.%22%2C%22lastName%22%3A%22Floyd%22%7D%5D%2C%22abstractNote%22%3A%22Spinal%20cord%20ischemia%20leads%20to%20iatrogenic%20injury%20in%20multiple%20surgical%20fields%2C%20and%20the%20ability%20to%20immediately%20identify%20onset%20and%20anatomic%20origin%20of%20ischemia%20is%20critical%20to%20its%20management.%20Current%20clinical%20monitoring%2C%20however%2C%20does%20not%20directly%20measure%20spinal%20cord%20blood%20flow%2C%20resulting%20in%20poor%20sensitivity%5C%2Fspecificity%2C%20delayed%20alerts%2C%20and%20delayed%20intervention.%20We%20have%20developed%20an%20epidural%20device%20employing%20diffuse%20correlation%20spectroscopy%20%28DCS%29%20to%20monitor%20spinal%20cord%20ischemia%20continuously%20at%20multiple%20positions.%20We%20investigate%20the%20ability%20of%20this%20device%20to%20localize%20spinal%20cord%20ischemia%20in%20a%20porcine%20model%20and%20validate%20DCS%20versus%20Laser%20Doppler%20Flowmetry%20%28LDF%29.%20Specifically%2C%20we%20demonstrate%20continuous%20%28%26gt%3B0.1Hz%29%20spatially%20resolved%20%283%20locations%29%20monitoring%20of%20spinal%20cord%20blood%20flow%20in%20a%20purely%20ischemic%20model%20with%20an%20epidural%20DCS%20probe.%20Changes%20in%20blood%20flow%20measured%20by%20DCS%20and%20LDF%20were%20highly%20correlated%20%28r%20%3D%200.83%29.%20Spinal%20cord%20blood%20flow%20measured%20by%20DCS%20caudal%20to%20aortic%20occlusion%20decreased%2062%25.%20This%20monitor%20demonstrated%20a%20sensitivity%20of%200.87%20and%20specificity%20of%200.91%20for%20detection%20of%20a%2025%25%20decrease%20in%20flow.%20This%20technology%20may%20enable%20early%20identification%20and%20critically%20important%20localization%20of%20spinal%20cord%20ischemia.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0251271%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-02T02%3A55%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22BI76D3QC%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Leal%20et%20al.%22%2C%22parsedDate%22%3A%222018-12-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLeal%2C%20J.%2C%20Dong%2C%20T.%2C%20Taylor%2C%20A.%20et%20al.%20%282018%29.%20Mucus-penetrating%20phage-displayed%20peptides%20for%20improved%20transport%20across%20a%20mucus-like%20model.%20%26lt%3Bi%26gt%3BInt%20J%20Pharm%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B553%26lt%3B%5C%2Fi%26gt%3B%2C%2057%26%23x2013%3B64.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijpharm.2018.09.055%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijpharm.2018.09.055%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mucus-penetrating%20phage-displayed%20peptides%20for%20improved%20transport%20across%20a%20mucus-like%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jasmim%22%2C%22lastName%22%3A%22Leal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tony%22%2C%22lastName%22%3A%22Dong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amber%22%2C%22lastName%22%3A%22Taylor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Siegrist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugh%20D.%20C.%22%2C%22lastName%22%3A%22Smyth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debadyuti%22%2C%22lastName%22%3A%22Ghosh%22%7D%5D%2C%22abstractNote%22%3A%22The%20objective%20of%20this%20work%20is%20to%20use%20phage%20display%20libraries%20as%20a%20screening%20tool%20to%20identify%20peptides%20that%20facilitate%20transport%20across%20the%20mucus%20barrier.%20Mucus%20is%20a%20complex%20selective%20barrier%20to%20particles%20and%20molecules%2C%20limiting%20penetration%20to%20the%20epithelial%20surface%20of%20mucosal%20tissues.%20In%20mucus-associated%20diseases%20such%20as%20cystic%20fibrosis%20%28CF%29%2C%20mucus%20has%20increased%20viscoelasticity%20and%20a%20higher%20concentration%20of%20covalent%20and%20non-covalent%20physical%20entanglements%20compared%20to%20healthy%20tissues%2C%20which%20greatly%20hinders%20permeability%20and%20transport%20of%20drugs%20and%20particles%20across%20the%20mucosae%20for%20therapeutic%20delivery.%20Treatment%20of%20CF%20lung%20diseases%20and%20associated%20infections%20must%20overcome%20this%20abnormal%20mucosal%20barrier.%20Critical%20bottlenecks%20hindering%20effective%20drug%20penetration%20remain%20and%20while%20recent%20studies%20have%20shown%20hydrophilic%2C%20net-neutral%20charge%20polymers%20can%20improve%20the%20transport%20of%20nanoparticles%20and%20minimize%20interactions%20with%20mucus%2C%20there%20is%20a%20dearth%20of%20alternative%20carriers%20available.%20We%20hypothesized%20that%20the%20screening%20of%20a%20phage%20peptide%20library%20against%20a%20CF%20mucus%20model%20would%20lead%20to%20the%20identification%20of%20phage-displayed%20peptide%20sequences%20able%20to%20improve%20transport%20in%20mucus.%20These%20combinatorial%20libraries%20possess%20a%20large%20diversity%20of%20peptide-based%20formulations%20%28108-109%29%20to%20achieve%20unprecedented%20screening%20for%20potential%20mucus-penetrating%20peptides.%20Here%2C%20phage%20clones%20displaying%20discovered%20peptides%20were%20shown%20to%20have%20up%20to%202.6-fold%20enhanced%20diffusivity%20in%20the%20CF%20mucus%20model.%20In%20addition%2C%20we%20demonstrate%20reduced%20binding%20affinities%20to%20mucin%20compared%20to%20wild-type%20control.%20These%20findings%20suggest%20that%20phage%20display%20libraries%20can%20be%20used%20as%20a%20strategy%20to%20improve%20transmucosal%20delivery.%22%2C%22date%22%3A%222018-12-20%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijpharm.2018.09.055%22%2C%22ISSN%22%3A%221873-3476%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-02T02%3A54%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22SPBGE7WY%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kashyap%20et%20al.%22%2C%22parsedDate%22%3A%222017%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKashyap%2C%20S.%2C%20Warner%2C%20G.%2C%20Hu%2C%20Z.%20et%20al.%20%282017%29.%20Cardiovascular%20phenotype%20in%20Smad3%20deficient%20mice%20with%20renovascular%20hypertension.%20%26lt%3Bi%26gt%3BPLoS%20One%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%2C%20e0187062.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0187062%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0187062%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cardiovascular%20phenotype%20in%20Smad3%20deficient%20mice%20with%20renovascular%20hypertension%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonu%22%2C%22lastName%22%3A%22Kashyap%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Warner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zeng%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazen%22%2C%22lastName%22%3A%22Osman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yousif%22%2C%22lastName%22%3A%22Al%20Saiegh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%20R.%22%2C%22lastName%22%3A%22Lien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl%22%2C%22lastName%22%3A%22Nath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20P.%22%2C%22lastName%22%3A%22Grande%22%7D%5D%2C%22abstractNote%22%3A%22Renovascular%20hypertension%20%28RVH%29%20has%20deleterious%20effects%20on%20both%20the%20kidney%20and%20the%20heart.%20TGF-%5Cu03b2%20signaling%20through%20Smad3%20directs%20tissue%20fibrosis%20in%20chronic%20injury%20models.%20In%20the%202-kidney%201-clip%20%282K1C%29%20model%20of%20RVH%2C%20employing%20mice%20on%20the%20129%20genetic%20background%2C%20Smad3%20deficiency%20%28KO%29%20protects%20the%20stenotic%20kidney%20%28STK%29%20from%20development%20of%20interstitial%20fibrosis.%20However%2C%20these%20mice%20have%20an%20increased%20incidence%20of%20sudden%20cardiac%20death%20following%202K1C%20surgery.%20The%20purpose%20of%20this%20study%20was%20to%20characterize%20the%20cardiovascular%20phenotype%20of%20these%20mice.%20Renal%20artery%20stenosis%20%28RAS%29%20was%20established%20in%20Wild-type%20%28WT%29%20and%20Smad3%20KO%20mice%20%28129%20genetic%20background%29%20by%20placement%20of%20a%20polytetrafluoroethylene%20cuff%20on%20the%20right%20renal%20artery.%20Mortality%20was%2025.5%25%20for%20KO%20mice%20with%20RAS%2C%204.1%25%20for%20KO%20sham%20mice%2C%201.2%25%20for%20WT%20with%20RAS%2C%20and%201.8%25%20for%20WT%20sham%20mice.%20Myocardial%20tissue%20of%20mice%20studied%20at%203%20days%20following%20surgery%20showed%20extensive%20myocyte%20necrosis%20in%20KO%20but%20not%20WT%20mice.%20Myocyte%20necrosis%20was%20associated%20with%20a%20rapid%20induction%20of%20Ccl2%20expression%2C%20macrophage%20influx%2C%20and%20increased%20MMP-9%20activity.%20At%20later%20time%20points%2C%20both%20KO%20and%20WT%20mice%20developed%20myocardial%20fibrosis.%20No%20aortic%20aneurysms%20or%20dissections%20were%20observed%20at%20any%20time%20point.%20Smad3%20KO%20mice%20were%20backcrossed%20to%20the%20C57BL%5C%2F6J%20strain%20and%20subjected%20to%20RAS.%20Sudden%20death%20was%20observed%20at%2010-14%20days%20following%20surgery%20in%2062.5%25%20of%20mice%3B%20necropsy%20revealed%20aortic%20dissections%20as%20the%20cause%20of%20death.%20As%20observed%20in%20the%20129%20mice%2C%20the%20STK%20of%20Smad3%20KO%20mice%20on%20the%20C57BL%5C%2F6J%20background%20did%20not%20develop%20significant%20chronic%20renal%20damage.%20We%20conclude%20that%20the%20cardiovascular%20manifestations%20of%20Smad3%20deficient%20mice%20are%20strain-specific%2C%20with%20myocyte%20necrosis%20in%20129%20mice%20and%20aortic%20rupture%20in%20C57BL%5C%2F6J%20mice.%20Future%20studies%20will%20define%20mechanisms%20underlying%20this%20strain-specific%20effect%20on%20the%20cardiovascular%20system.%22%2C%22date%22%3A%222017%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0187062%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22FKNSPK49%22%5D%2C%22dateModified%22%3A%222023-07-02T02%3A54%3A36Z%22%7D%7D%5D%7D
Gao, F., Kherallah, R., Koetting, M. et al. (2023). Leadless pacemaker with transcatheter aortic valve implantation: A single-center experience. Pacing Clin Electrophysiol. https://doi.org/10.1111/pace.14702.
Potter, A. S., Patel, A., Khawaja, M. et al. (2022). Outcomes by Class of Anticoagulant Use for Nonvalvular Atrial Fibrillation in Patients With Active Cancer. JACC CardioOncol 4, 341–350. https://doi.org/10.1016/j.jaccao.2022.07.004.
Gao, F. and Rahman, F. (2022). DOACs and Atherosclerotic Cardiovascular Disease Management: Can We Find the Right Balance Between Efficacy and Harm. Curr Atheroscler Rep 24, 457–469. https://doi.org/10.1007/s11883-022-01022-w.
Gao, F., Wahl, J. A. and Floyd, T. F. (2022). Anesthesia and neurotoxicity study design, execution, and reporting in the nonhuman primate: A systematic review. Paediatr Anaesth 32, 509–521. https://doi.org/10.1111/pan.14401.
Gao, F., Koh, S., Taveras-Alam, S. et al. (2022). A Right Atrial Mass with Fever and Cutaneous Nodules. Methodist Debakey Cardiovasc J 18, 48–53. https://doi.org/10.14797/mdcvj.1126.
Gao, F. and Khalid, U. (2021). Inadvertent Septal Ablation During Percutaneous Coronary Intervention. Cureus 13, e19227. https://doi.org/10.7759/cureus.19227.
Jia, X., Gao, F., Pickett, J. K. et al. (2021). Association between omega-3 fatty acid treatment and atrial fibrillation in cardiovascular outcome trials: A systematic review and meta-analysis. Cardiovasc Drugs Ther 35, 793–800. https://doi.org/10.1007/s10557-021-07204-z.
Busch, D. R., Lin, W., Goh, C. C. et al. (2021). Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring. PLoS One 16, e0251271. https://doi.org/10.1371/journal.pone.0251271.
Leal, J., Dong, T., Taylor, A. et al. (2018). Mucus-penetrating phage-displayed peptides for improved transport across a mucus-like model. Int J Pharm 553, 57–64. https://doi.org/10.1016/j.ijpharm.2018.09.055.
Kashyap, S., Warner, G., Hu, Z. et al. (2017). Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. PLoS One 12, e0187062. https://doi.org/10.1371/journal.pone.0187062.