Shiladitya Sengupta, PhD

Shiladitya Sengupta, PhD, joined Scientific Publications and Grants Department at the Texas Heart Institute as a senior scientific grant writer in December 2018. He received his doctoral degree in Life Sciences from Jadavpur University, India in 2008. Before joining Texas Heart Institute, he worked at Houston Methodist Research Institute and University of Texas Medical Branch at Galveston as a research scientist. His research interest was on genome damage repair and transcriptional regulation. He was a Keck Fellow of CPRIT funded Gulf Coast Consortia's Computational Cancer Biology Training Program. He spends quality time with family and enjoys cooking and traveling. Show full bio

Shiladitya Sengupta, PhD, joined Scientific Publications and Grants Department at the Texas Heart Institute as a senior scientific grant writer in December 2018. He received his doctoral degree in Life Sciences from Jadavpur University, India in 2008. Before joining Texas Heart Institute, he worked at Houston Methodist Research Institute and University of Texas Medical Branch at Galveston as a research scientist. His research interest was on genome damage repair and transcriptional regulation. He was a Keck Fellow of CPRIT funded Gulf Coast Consortia’s Computational Cancer Biology Training Program. He spends quality time with family and enjoys cooking and traveling.

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Texas Heart Institute Positions

Education

  • Undergraduate:

    University of Calcutta, India

  • Postgraduate:

    Jadavpur University (India), University of Texas Medical Branch at Galveston

Honors, Awards and Memberships

  • Young Scientist Award
  • Indian Society of Human Genetics

Publications

Bacolla, A., Sengupta, S., Ye, Z. et al. (2021). Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic Acids Res 49, 221–243. https://doi.org/10.1093/nar/gkaa1120.
Sengupta, S., Wang, H., Yang, C. et al. (2020). Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proc Natl Acad Sci U S A 117, 22183–22192. https://doi.org/10.1073/pnas.1919445117.
Bhakat, K. K., Sengupta, S. and Mitra, S. (2020). Fine-tuning of DNA base excision/strand break repair via acetylation. DNA Repair (Amst) 93, 102931. https://doi.org/10.1016/j.dnarep.2020.102931.
Sengupta, S., Yang, C., Eckelmann, B. J. et al. (2018). Regulation of Oxidized Base Repair in Human Chromatin by Posttranslational Modification. In Advances in DNA Repair. Available at: https://www.intechopen.com/online-first/regulation-of-oxidized-base-repair-in-human-chromatin-by-posttranslational-modification [Accessed February 6, 2019].
Sengupta, S., Yang, C., Hegde, M. L. et al. (2018). Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA Repair 66–67, 1–10. https://doi.org/10.1016/j.dnarep.2018.04.001.
Yang, C., Sengupta, S., Hegde, P. M. et al. (2017). Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic Acids Research 45, 739–748. https://doi.org/10.1093/nar/gkw1024.
Vasquez, V., Mitra, J., Hegde, P. M. et al. (2017). Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease. Journal of Alzheimer’s Disease 60, S133–S150. https://doi.org/10.3233/JAD-170342.
Roychoudhury, S., Nath, S., Song, H. et al. (2017). Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity. Molecular and Cellular Biology 37. https://doi.org/10.1128/MCB.00401-16.
Dutta, A., Eckelmann, B., Adhikari, S. et al. (2017). Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic Acids Research 45, 2585–2599. https://doi.org/10.1093/nar/gkw1262.
Bhakat, K. K., Sengupta, S., Adeniyi, V. F. et al. (2016). Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget 7, 22590–22604. https://doi.org/10.18632/oncotarget.8026.