O.H. Frazier, MD

Dr. O. H. Frazier, M.D. is a living legend and celebrated for his contributions to the field of mechanical circulatory support and pioneering treatments for patients suffering from heart failure. He performed over 1,300 heart transplants and implanted more than 900 left ventricular assist devices, more than any other surgeon in the world. Today he serves as the Co-Director of Center for Preclinical Surgical & Interventional Research at THI. Show full bio

For more than 30 years, Dr. O. H. Frazier has been a pioneer in the treatment of severe heart failure and in the fields of heart transplantation and artificial devices that may be used either to substitute for or assist the pumping action of the human heart. As a result of his work, he become one of the top transplantation and mechanical circulatory support surgeons in the world. Dr. Frazier performed over 1,200 heart transplants and implanted more than 900 left ventricular assist devices, more than any other surgeon in the world.

Dr. Frazier’s interest in mechanical circulatory support began in 1969, when, as a student at Baylor College of Medicine, he wrote a research paper about the experimental total artificial heart, which was first implanted in 1969 by Dr. Denton Cooley. Throughout the 1970s and 1980s, Dr. Frazier continued experimental work toward developing an implantable left ventricular assist device (LVAD) to aid the failing heart.In 2011, Dr. Frazier implanted the first successful continuous-flow total artificial heart using two second generation HeartMate II LVADs to replace a patient’s failing heart.

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  • Undergraduate:

    University of Texas

  • Medical School:

    Baylor College of Medicine

  • Residency:

    Baylor College of Medicine

  • Fellowships:

    Texas Heart Institute/Baylor College of Medicine


  • American Board of Thoracic Surgery
  • American Board of Surgery

Honors, Awards and Memberships


Recent News

Sharing Science Globally to Advance Medicine

Texas Heart Institute has been at the forefront of cardiovascular discovery and innovation since its formation. It continues to relentlessly...

Humanity inspired by Dr. Denton Cooley

“…thanks to Dr. Cooley, humanity will continue to be inspired and take advantage of its chances until heart disease is...

Life Imitates Art: A Behind the Scenes Discussion of the Total Artificial Heart and Threshold (1981)

Dr. Bud Frazier Presents the movie Threshold (1981) at the Historic Brown Auditorium Theatre On September 15, Dr. Bud Frazier...