Alexander Postalian, MD, FSCAI

Dr. Postalian is a cardiologist at The Texas Heart Institute, acting as a member of the teaching staff for the Institute’s cardiovascular disease training programs and as an associate editor for The Texas Heart Institute Journal. Dr. Postalian specializes in coronary, peripheral vascular, and structural/valvular heart disease intervention. His specific clinical and research areas of interest include cardiovascular disease prevention – including complex lipid disorder management, state-of-the-art coronary intervention guided by intravascular imaging and flow assessment, next-day discharge transcatheter aortic valve replacement, and minimally invasive abdominal aortic aneurysm treatment. Dr. Postalian has completed board certification examinations in Cardiovascular Diseases, Interventional Cardiology, Echocardiography, Nuclear Cardiology, and Internal Medicine. He has been recognized as a Texas Superdoctors Rising Star and as a Houstonia Top Doctor.

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Dr. Postalian is a graduate of the Texas Heart Institute’s interventional and general cardiology fellowship training programs sponsored by Baylor College of Medicine. He was honored with the Tauber Award as the outstanding graduating cardiology fellow. Prior to his cardiology fellowship, Dr. Postalian completed an internal medicine residency at The McGovern Medical School, University of Texas Health Science Center at Houston. During residency training, he was honored as the Outstanding Senior Resident of the Year, Outstanding Resident of the Year, and Outstanding Intern of the Year – being the only resident to have been recognized with these three awards in the recent history of the school.

Dr. Postalian serves as Associate Editor of the Texas Heart Institute Journal and is also a reviewer for multiple other medical journals. He is an active researcher with several peer-reviewed publications, performing many abstract presentations, and frequently giving oral presentations in several national and international meetings.

Originally from Venezuela, he graduated first in his class from medical school at the Universidad Central de Venezuela in 2010, obtaining the distinction of Magna Cum Laude. He also received the Lorenzo Campins y Ballester award and the Luis Razetti Award for outstanding academic achievement and research accomplishment.

Outside of work, Dr. Postalian enjoys exercising, the beach, motorsports, playing video games, and spending time with his wife and children.

Connect with Alex on Twitter @APostalian

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Education

  • Medical School:

    Central University of Venezuela

  • Internship:

    The University of Texas Health Science Center at Houston - McGovern Medical School

  • Residency:

    The University of Texas Health Science Center at Houston - McGovern Medical School

  • Fellowships:

    Texas Heart Institute (General Cardiology)

Certifications

  • American Board of Internal Medicine
  • Basic Life Support (BLS) Course
  • Advanced Cardiovascular Life Support (ACLS) Course

Honors, Awards and Memberships

Publications

4862227 849YWXRD 1 alternatives-to-animal-experimentation 10 date desc Postalian 2054 https://www.texasheart.org/wp-content/plugins/zotpress/
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Doliner, B., Gaddar, H., Kalil, R. et al. (2024). Modern Perspectives on Hypertrophic Cardiomyopathy—No One Size Fits All. Texas Heart Institute Journal 51, e248423. https://doi.org/10.14503/THIJ-24-8423.
Postalian, A. and Krajcer, Z. (2023). The relationship between chronic kidney disease and “complex” percutaneous coronary intervention: Uncovering the details. Catheter Cardiovasc Interv 101, 949–950. https://doi.org/10.1002/ccd.30612.
Postalian, A. (2022). The “Pro-Seal” large-bore arterial access closure technique: Making the best of what is available. Tex Heart Inst J 49, e227964. https://doi.org/10.14503/THIJ-22-7964.
ACTIV-3/TICO Study Group, Rogers, A. J., Wentworth, D. et al. (2022). The association of baseline plasma sars-cov-2 nucleocapsid antigen level and outcomes in patients hospitalized with COVID-19. Ann Intern Med 175, 1401–1410. https://doi.org/10.7326/M22-0924.
Postalian, A., Kuchibhotla, S., Koneru, S. et al. (2022). A special clinical scenario for transcatheter aortic valve replacement: “iatrogenic double-outlet” left ventricle. Tex Heart Inst J 49, e227889. https://doi.org/10.14503/THIJ-22-7889.
ACTIV-3/TICO Study Group, Barkauskas, C., Mylonakis, E. et al. (2022). Efficacy and safety of ensovibep for adults hospitalized with COVID-19: a randomized controlled trial. Ann Intern Med 175, 1266–1274. https://doi.org/10.7326/M22-1503.
Postalian, A. and Krajcer, Z. (2022). Mitral annular calcification-A marker of risk, and a harbinger of technical challenges during intervention. Catheter Cardiovasc Interv 99, 1817–1818. https://doi.org/10.1002/ccd.30216.
Postalian, A. and Krajcer, Z. (2022). Facilitating future access to the coronary arteries in patients who need transcatheter aortic valve replacement: A significant step in the right direction. Catheter Cardiovasc Interv 99, 932–933. https://doi.org/10.1002/ccd.30124.
Angelini, P., Postalian, A., Hernandez-Vila, E. et al. (2022). COVID-19 and the heart: could transient takotsubo cardiomyopathy be related to the pandemic by incidence and mechanisms? Front Cardiovasc Med 9, 919715. https://doi.org/10.3389/fcvm.2022.919715.
Postalian, A. and Krajcer, Z. (2021). Outflow graft obstruction in patients with left ventricular assist devices: Stenting the kink. Catheter Cardiovasc Interv 98, 1391–1392. https://doi.org/10.1002/ccd.29994.

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