Shijie Liu, PhD
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4862227 62EHAB8G 1 alternatives-to-animal-experimentation 10 date desc Liu 53763 https://www.texasheart.org/wp-content/plugins/zotpress/
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Zhang, S., Liu, S., Leach, J. P. et al. (2022). Gene therapy knockdown of hippo signaling resolves arrhythmic events in pigs after myocardial infarction. Circulation 146, 1558–1560. https://doi.org/10.1161/CIRCULATIONAHA.122.059972.
Liu, S., Li, R. G. and Martin, J. F. (2022). The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. J Mol Cell Cardiol 168, 98–106. https://doi.org/10.1016/j.yjmcc.2022.04.018.
Liu, S. and Martin, J. F. (2022). RNA splicing to cytoskeleton: A new path to cardiomyocyte ploidy and division? Dev Cell 57, 945–946. https://doi.org/10.1016/j.devcel.2022.04.002.
Liu, S., Tang, L., Zhao, X. et al. (2021). Yap promotes noncanonical Wnt signals from cardiomyocytes for heart regeneration. Circ Res 129, 782–797. https://doi.org/10.1161/CIRCRESAHA.121.318966.
Liu, S., Li, K., Wagner Florencio, L. et al. (2021). Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med 13, eabd6892. https://doi.org/10.1126/scitranslmed.abd6892.

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