Shahrzad Abbasi, MS

See Publications

Texas Heart Institute Positions

Research Associate I, Molecular Cardiology Research

Interests

Non-invasive diagnostic imaging technologies

Publications

4862227 JH9V95Q8 1 alternatives-to-animal-experimentation 10 date desc Abbasi 1795 https://www.texasheart.org/wp-content/plugins/zotpress/

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Ma, Y., Cheng, N., Sun, J. et al. (2020). Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation. Lipids Health Dis 19, 189. https://doi.org/10.1186/s12944-020-01368-7.

Woodside, D. G., Tanifum, E. A., Ghaghada, K. B. et al. (2018). Magnetic resonance imaging of atherosclerotic plaque at clinically relevant field strengths (1T) by targeting the integrin α4β1. Sci Rep 8, 3733. https://doi.org/10.1038/s41598-018-21893-x.

Xi, Y., James Chao, Z.-Y., Yan, W. et al. (2015). Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation. Heart Rhythm 12, 1352–1361. https://doi.org/10.1016/j.hrthm.2015.03.003.

Sun, J., Zhang, J., Yan, W. et al. (2014). Iloprost prevents doxorubicin mediated human cardiac progenitor cell depletion. Int J Cardiol 176, 536–539. https://doi.org/10.1016/j.ijcard.2014.07.031.

Xi, Y., Wu, G., Ai, T. et al. (2013). Ionic mechanisms underlying the effects of vasoactive intestinal polypeptide on canine atrial myocardium. Circ Arrhythm Electrophysiol 6, 976–983. https://doi.org/10.1161/CIRCEP.113.000518.

Barakat, O., Abbasi, S., Rodriguez, G. et al. (2012). Use of decellularized porcine liver for engineering humanized liver organ. J Surg Res 173, e11-25. https://doi.org/10.1016/j.jss.2011.09.033.

Zhou, C. C., Chang, J., Mi, T. et al. (2012). Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice. PLoS ONE 7, e29236. https://doi.org/10.1371/journal.pone.0029236.

Wu, G., Ai, T., Kim, J. J. et al. (2008). α-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ Arrhythm Electrophysiol 1, 193–201. https://doi.org/10.1161/CIRCEP.108.769224.

Mi, T., Abbasi, S., Zhang, H. et al. (2008). Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 118, 1491–1501. https://doi.org/10.1172/JCI33467.

Zhou, C. C., Ahmad, S., Mi, T. et al. (2007). Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circ Res 100, 88–95. https://doi.org/10.1161/01.RES.0000254703.11154.18.