Chu-Huang (Mendel) Chen, MD, PhD

Texas Heart Institute Positions

  • Director, Vascular and Medicinal Research, Molecular Cardiology Research


  • Postgraduate:

    Texas Tech University

  • Medical School:

    Kaohsiung Medical University, Taiwan

  • Residency:

    Chang-Gung Memorial Hospital, Taiwan (Pathology)
    Maryland General Hospital & Univ. of Maryland (Internal Medicine)

  • Fellowships:

    Baylor College of Medicine

Academic & Clinical Affiliations

Honors, Awards and Memberships

  • The Texas Heart Institute Academic Professional Staff
  • Mentored Outstanding Scholars (Ministry of Science and Technology-Taiwan)2017-2020
  • Editorial board, Kaohsiung Journal of Medical Sciences, 2016–present
  • Outstanding Faculty Teaching Award of China Medical University, 2015
  • Best Clinical Teacher Award of China Medical University Hospital, 2015
  • Outstanding Alumni Award, Kaohsiung Medical University, Taiwan, 2014--life time
  • 12th Generation Chen Style Tai Chi Selected Disciple, 2013–life time
  • Editorial board, Biomedical Journal 2013–present
  • Elite physician of Internal Medicine in China Medical University Hospital, 2013
  • Philip Morris Research Award, 2005–2008
  • Texas Medical Center/NASA Cooperative Research Grant, 1995–1996
  • American Diabetes Association
  • AHA, Atherosclerosis Council
  • International Atherosclerosis Society
  • American Association for the Advancement of Science
  • The Angiogenesis Society


Kraler, S., Wenzl, F. A., Vykoukal, J. et al. (2023). Low-density lipoprotein electronegativity and risk of death after acute coronary syndromes: A case-cohort analysis. Atherosclerosis 376, 43–52.
Chen, T.-C., Hsu, W.-L., Wu, C.-Y. et al. (2023). Effect of omega-6 linoleic acid on neurobehavioral development in Caenorhabditis elegans. Prostaglandins Leukot Essent Fatty Acids 191, 102557.
Wu, C.-H., Hsu, W.-L., Tsai, C.-C. et al. (2023). 7,10,13,16-Docosatetraenoic acid impairs neurobehavioral development by increasing reactive oxidative species production in Caenorhabditis elegans. Life Sci 319, 121500.
Hosomi, K., Kawashima, H., Nakano, A. et al. (2022). NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36. Cardiovasc Res, cvac167.
Chang, C.-K., Chang, K.-H., Cheng, W.-C. et al. (2022). Lipid metabolomic signature might predict subclinical atherosclerosis in patients with active rheumatoid arthritis. Clin Exp Rheumatol.
Lee, H.-C., Akhmedov, A. and Chen, C.-H. (2022). Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: Implications for disease progression and mechanistic insights. Front Cardiovasc Med 9, 993633.
Lin, K.-C., Ting, L.-L., Chang, C.-L. et al. (2021). Ex vivo expanded circulating tumor cells for clinical anti-cancer drug prediction in patients with head and neck cancer. Cancers (Basel) 13, 6076.
Tsai, M.-H., Chao, H.-R., Hsu, W.-L. et al. (2021). Analysis of polybrominated diphenyl ethers and lipid composition in human breast milk and their correlation with infant neurodevelopment. Int J Environ Res Public Health 18, 11501.
Chang, C.-K., Cheng, W.-C., Ma, W.-L. et al. (2021). The potential role of electronegative high-density lipoprotein H5 subfraction in RA-related atherosclerosis. Int J Mol Sci 22, 11419.
Chang, C.-K., Chen, P.-K., Chen, C.-C. et al. (2021). Increased levels of omega-3 fatty acids and DHA are linked to pain reduction in rheumatoid arthritis patients treated with Janus kinase inhibitors. Nutrients 13, 3050.