Kathleen Kibler, LP, CCP

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Texas Heart Institute Positions

Perfusion Research Coordinator, School of Perfusion Technology

Publications

4862227 YNMEKWC8 1 alternatives-to-animal-experimentation 10 date desc Kibler 25569 https://www.texasheart.org/wp-content/plugins/zotpress/

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Elizondo, L. I., Rios, D. R., Vu, E. et al. (2019). Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants. Pediatr Res 86, 242–246. https://doi.org/10.1038/s41390-019-0403-y.

Cabrera, A. G., Kibler, K. K., Blaine Easley, R. et al. (2018). Elevated arterial blood pressure after superior cavo-pulmonary anastomosis is associated with elevated pulmonary artery pressure and cerebrovascular dysautoregulation. Pediatr Res 84, 356–361. https://doi.org/10.1038/pr.2018.31.

Easley, R. B., Marino, B. S., Jennings, J. et al. (2018). Impaired cerebral autoregulation and elevation in plasma glial fibrillary acidic protein level during cardiopulmonary bypass surgery for CHD. Cardiol Young 28, 55–65. https://doi.org/10.1017/S1047951117001573.

Smith, B., Vu, E., Kibler, K. et al. (2017). Does hypothermia impair cerebrovascular autoregulation in neonates during cardiopulmonary bypass? Paediatr Anaesth 27, 905–910. https://doi.org/10.1111/pan.13194.

Goswami, D., McLeod, K., Leonard, S. et al. (2017). Static cerebrovascular pressure autoregulation remains intact during deep hypothermia. Paediatr Anaesth 27, 911–917. https://doi.org/10.1111/pan.13205.

Vu, E. L., Rusin, C. G., Penny, D. J. et al. (2017). A Novel Electrocardiogram Algorithm Utilizing ST-Segment Instability for Detection of Cardiopulmonary Arrest in Single Ventricle Physiology: A Retrospective Study. Pediatr Crit Care Med 18, 44–53. https://doi.org/10.1097/PCC.0000000000000980.

Busch, D. R., Rusin, C. G., Miller-Hance, W. et al. (2016). Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. Biomed Opt Express 7, 3461–3470. https://doi.org/10.1364/BOE.7.003461.

Rhee, C. J., Kaiser, J. R., Rios, D. R. et al. (2016). Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants. J Pediatr 174, 52–56. https://doi.org/10.1016/j.jpeds.2016.03.066.

Rhee, C. J., Kibler, K. K., Easley, R. B. et al. (2016). The diastolic closing margin is associated with intraventricular hemorrhage in premature infants. Acta Neurochir Suppl 122, 147–150. https://doi.org/10.1007/978-3-319-22533-3_30.

Rhee, C. J., Fraser, C. D., Kibler, K. et al. (2016). The ontogeny of cerebrovascular pressure autoregulation in premature infants. Acta Neurochir Suppl 122, 151–155. https://doi.org/10.1007/978-3-319-22533-3_31.