John Tyler III, MD
See Publications

Education

  • Medical School:

    University of Texas Health Science Center Houston

  • Residency:

    University of Alabama - Birmingham

  • Fellowships:

    The Texas Heart Institute

Academic & Clinical Affiliations

Honors, Awards and Memberships

Publications

4862227 8Y8K4QJA 1 alternatives-to-animal-experimentation 10 date desc Tyler 2140 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228VI5SQJW%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Prins%20et%20al.%22%2C%22parsedDate%22%3A%222015-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPrins%2C%20K.%20W.%2C%20Neill%2C%20J.%20M.%2C%20%26lt%3Bstrong%26gt%3BTyler%26lt%3B%5C%2Fstrong%26gt%3B%2C%20J.%20O.%20et%20al.%20%282015%29.%20Effects%20of%20beta-blocker%20withdrawal%20in%20acute%20decompensated%20heart%20failure%3A%20a%20systematic%20review%20and%20meta-analysis.%20%26lt%3Bi%26gt%3BJACC%20Heart%20Fail%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%2C%20647%26%23x2013%3B653.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jchf.2015.03.008%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jchf.2015.03.008%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effects%20of%20beta-blocker%20withdrawal%20in%20acute%20decompensated%20heart%20failure%3A%20a%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kurt%20W.%22%2C%22lastName%22%3A%22Prins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20M.%22%2C%22lastName%22%3A%22Neill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20O.%22%2C%22lastName%22%3A%22Tyler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20M.%22%2C%22lastName%22%3A%22Eckman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sue%22%2C%22lastName%22%3A%22Duval%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20This%20study%20sought%20to%20evaluate%20the%20effects%20of%20beta-blocker%20withdrawal%20in%20acute%20decompensated%20heart%20failure%20%28ADHF%29.%5CnBACKGROUND%3A%20Published%20reports%20showed%20trends%20for%20either%20no%20harm%20or%20increased%20risk%20of%20in-hospital%20mortality%2C%20short-term%20mortality%2C%20and%20rehospitalization%20rates%20in%20patients%20admitted%20for%20ADHF%20that%20discontinued%20beta-blockers%3B%20however%2C%20a%20comprehensive%20analysis%20has%20not%20been%20conducted.%5CnMETHODS%3A%20Relevant%20studies%20from%20January%202000%20through%20January%202015%20were%20identified%20in%20the%20PubMed%2C%20EMBASE%2C%20and%20COCHRANE%20electronic%20databases.%20Where%20appropriate%20data%20were%20available%2C%20weighted%20relative%20risks%20were%20estimated%20using%20random-effects%20meta-analysis%20techniques.%5CnRESULTS%3A%20Five%20observational%20studies%20and%201%20randomized%20clinical%20trial%20%28n%20%3D%202%2C704%20patients%20who%20continued%20beta-blocker%20therapy%20and%20n%20%3D%20439%20patients%20who%20discontinued%20beta-blocker%20therapy%29%20that%20reported%20the%20short-term%20effects%20of%20beta-blocker%20withdrawal%20in%20ADHF%20were%20included%20in%20the%20analyses.%20In%202%20studies%2C%20beta-blocker%20withdrawal%20significantly%20increased%20risk%20of%20in-hospital%20mortality%20%28risk%20ratio%3A%203.72%3B%2095%25%20confidence%20interval%20%5BCI%5D%3A%201.51%20to%209.14%29.%20Short-term%20mortality%20%28relative%20risk%3A%201.61%3B%2095%25%20CI%3A%201.04%20to%202.49%3B%204%20studies%29%20and%20combined%20short-term%20rehospitalization%20or%20death%20%28relative%20risk%3A%201.59%3B%2095%25%20CI%3A%201.03%20to%202.45%3B%204%20studies%29%20were%20also%20significantly%20increased.%5CnCONCLUSIONS%3A%20Discontinuation%20of%20beta-blockers%20in%20patients%20admitted%20with%20ADHF%20was%20associated%20with%20significantly%20increased%20in-hospital%20mortality%2C%20short-term%20mortality%2C%20and%20the%20combined%20endpoint%20of%20short-term%20rehospitalization%20or%20mortality.%20These%20data%20suggest%20beta-blockers%20should%20be%20continued%20in%20ADHF%20patients%20if%20their%20clinical%20picture%20allows.%22%2C%22date%22%3A%22Aug%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jchf.2015.03.008%22%2C%22ISSN%22%3A%222213-1787%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%228Y8K4QJA%22%5D%2C%22dateModified%22%3A%222018-05-21T21%3A06%3A45Z%22%7D%7D%5D%7D
Prins, K. W., Neill, J. M., Tyler, J. O. et al. (2015). Effects of beta-blocker withdrawal in acute decompensated heart failure: a systematic review and meta-analysis. JACC Heart Fail 3, 647–653. https://doi.org/10.1016/j.jchf.2015.03.008.