Briana Costello, MD, FSCAI

Dr. Costello is a general and interventional cardiologist who trained at The Texas Heart Institute and Baylor St. Luke’s Medical Center. In addition to coronary and structural interventions, she has an interest in cardiovascular preventive medicine and women’s heart health.

Show full bio

Dr. Costello completed her medical degree from Wright State University Boonshoft School of Medicine and earned Alpha Omega Alpha honors. She went on to complete her internal medicine residency at Rush University Medical Center in Chicago, Illinois.

Dr. Costello served on the Teaching Staff at The Texas Heart Institute for interventional cardiology and general cardiovascular disease. 

She is a Physician Ambassador for The Texas Heart Institute’s Center for Women’s Heart & Vascular Health and participates in a multitude of events aimed at teaching the general public about heart disease in women.

Dr. Costello is on the American Heart Association’s Council on Clinical Cardiology (CLCD) Women in Cardiology Committee. This committee is dedicated to promoting excellence in women’s heart health along with fostering professional development and education among others in the field of cardiology.

Dr. Costello has accumulated a substantial following on twitter and was noted in the AIMS Public Health Journal’s Top 100 Twitter influencers in Cardiology. She uses Twitter to collaborate with her peers in both in cardiology and other specialties while also providing a platform for physicians in training to learn from leaders in cardiology around the globe. She also served as the Social Media Editor for The Texas Heart Institute Journal.

When Dr. Costello is not working, she enjoys exercising and spending time outdoors with her husband and children. You can find her on Twitter @bcostelloMD

 

 


 

See Publications

Education

  • Medical School:

    Wright State University Boonshoft School of Medicine

  • Residency:

    Rush University Medical Center

  • Fellowships:

    The Texas Heart Institute (Cardiology)
    The Texas Heart Institute (Interventional Cardiology)

Academic & Clinical Affiliations

  • Knoxville Heart Group (Covenant Health), Tennessee

Publications

4862227 QSVIJDTT 1 alternatives-to-animal-experimentation 10 date desc Costello 1875 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22Z2KFACN7%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22ACTIV-3%5C%2FTICO%20Study%20Group%20et%20al.%22%2C%22parsedDate%22%3A%222022-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BACTIV-3%5C%2FTICO%20Study%20Group%2C%20Rogers%2C%20A.%20J.%2C%20Wentworth%2C%20D.%20et%20al.%20%282022%29.%20The%20association%20of%20baseline%20plasma%20sars-cov-2%20nucleocapsid%20antigen%20level%20and%20outcomes%20in%20patients%20hospitalized%20with%20COVID-19.%20%26lt%3Bi%26gt%3BAnn%20Intern%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B175%26lt%3B%5C%2Fi%26gt%3B%2C%201401%26%23x2013%3B1410.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7326%5C%2FM22-0924%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7326%5C%2FM22-0924%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20association%20of%20baseline%20plasma%20sars-cov-2%20nucleocapsid%20antigen%20level%20and%20outcomes%20in%20patients%20hospitalized%20with%20COVID-19%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ACTIV-3%5C%2FTICO%20Study%20Group%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20J.%22%2C%22lastName%22%3A%22Rogers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deborah%22%2C%22lastName%22%3A%22Wentworth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katy%22%2C%22lastName%22%3A%22Shaw-Saliba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%20L.%22%2C%22lastName%22%3A%22Dewar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neil%20R.%22%2C%22lastName%22%3A%22Aggarwal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdel%20G.%22%2C%22lastName%22%3A%22Babiker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weizhong%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nila%20J.%22%2C%22lastName%22%3A%22Dharan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victoria%20J.%22%2C%22lastName%22%3A%22Davey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20S.%22%2C%22lastName%22%3A%22Higgs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norman%22%2C%22lastName%22%3A%22Gerry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adit%20A.%22%2C%22lastName%22%3A%22Ginde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20W.%20Awori%22%2C%22lastName%22%3A%22Hayanga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helene%22%2C%22lastName%22%3A%22Highbarger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeroen%20L.%22%2C%22lastName%22%3A%22Highbarger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamta%20K.%22%2C%22lastName%22%3A%22Jain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginia%22%2C%22lastName%22%3A%22Kan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kami%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Perrine%22%2C%22lastName%22%3A%22Lallemand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bradley%20G.%22%2C%22lastName%22%3A%22Leshnower%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20K.%22%2C%22lastName%22%3A%22Lutaakome%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gail%22%2C%22lastName%22%3A%22Matthews%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmad%22%2C%22lastName%22%3A%22Mourad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleftherios%22%2C%22lastName%22%3A%22Mylonakis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ven%22%2C%22lastName%22%3A%22Natarajan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20L.%22%2C%22lastName%22%3A%22Padilla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavannya%20M.%22%2C%22lastName%22%3A%22Pandit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Paredes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Pett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srikanth%22%2C%22lastName%22%3A%22Ramachandruni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20Tauseef%22%2C%22lastName%22%3A%22Rehman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brad%20T.%22%2C%22lastName%22%3A%22Sherman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%20Clark%22%2C%22lastName%22%3A%22Files%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20M.%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Matthay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20Taylor%22%2C%22lastName%22%3A%22Thompson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Neaton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20Clifford%22%2C%22lastName%22%3A%22Lane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%20D.%22%2C%22lastName%22%3A%22Lundgren%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Levels%20of%20plasma%20SARS-CoV-2%20nucleocapsid%20%28N%29%20antigen%20may%20be%20an%20important%20biomarker%20in%20patients%20with%20COVID-19%20and%20enhance%20our%20understanding%20of%20the%20pathogenesis%20of%20COVID-19.%5CnOBJECTIVE%3A%20To%20evaluate%20whether%20levels%20of%20plasma%20antigen%20can%20predict%20short-term%20clinical%20outcomes%20and%20identify%20clinical%20and%20viral%20factors%20associated%20with%20plasma%20antigen%20levels%20in%20hospitalized%20patients%20with%20SARS-CoV-2.%5CnDESIGN%3A%20Cross-sectional%20study%20of%20baseline%20plasma%20antigen%20level%20from%202540%20participants%20enrolled%20in%20the%20TICO%20%28Therapeutics%20for%20Inpatients%20With%20COVID-19%29%20platform%20trial%20from%20August%202020%20to%20November%202021%2C%20with%20additional%20data%20on%20day%205%20outcome%20and%20time%20to%20discharge.%5CnSETTING%3A%20114%20centers%20in%2010%20countries.%5CnPARTICIPANTS%3A%20Adults%20hospitalized%20for%20acute%20SARS-CoV-2%20infection%20with%2012%20days%20or%20less%20of%20symptoms.%5CnMEASUREMENTS%3A%20Baseline%20plasma%20viral%20N%20antigen%20level%20was%20measured%20at%20a%20central%20laboratory.%20Delta%20variant%20status%20was%20determined%20from%20baseline%20nasal%20swabs%20using%20reverse%20transcriptase%20polymerase%20chain%20reaction.%20Associations%20between%20baseline%20patient%20characteristics%20and%20viral%20factors%20and%20baseline%20plasma%20antigen%20levels%20were%20assessed%20using%20both%20unadjusted%20and%20multivariable%20modeling.%20Association%20between%20elevated%20baseline%20antigen%20level%20of%201000%20ng%5C%2FL%20or%20greater%20and%20outcomes%2C%20including%20worsening%20of%20ordinal%20pulmonary%20scale%20at%20day%205%20and%20time%20to%20hospital%20discharge%2C%20were%20evaluated%20using%20logistic%20regression%20and%20Fine-Gray%20regression%20models%2C%20respectively.%5CnRESULTS%3A%20Plasma%20antigen%20was%20below%20the%20level%20of%20quantification%20in%205%25%20of%20participants%20at%20enrollment%2C%20and%201000%20ng%5C%2FL%20or%20greater%20in%2057%25.%20Baseline%20pulmonary%20severity%20of%20illness%20was%20strongly%20associated%20with%20plasma%20antigen%20level%2C%20with%20mean%20plasma%20antigen%20level%203.10-fold%20higher%20among%20those%20requiring%20noninvasive%20ventilation%20or%20high-flow%20nasal%20cannula%20compared%20with%20room%20air%20%2895%25%20CI%2C%202.22%20to%204.34%29.%20Plasma%20antigen%20level%20was%20higher%20in%20those%20who%20lacked%20antispike%20antibodies%20%286.42%20fold%3B%20CI%2C%205.37%20to%207.66%29%20and%20in%20those%20with%20the%20Delta%20variant%20%281.73%20fold%3B%20CI%2C%201.41%20to%202.13%29.%20Additional%20factors%20associated%20with%20higher%20baseline%20antigen%20level%20included%20male%20sex%2C%20shorter%20time%20since%20hospital%20admission%2C%20decreased%20days%20of%20remdesivir%2C%20and%20renal%20impairment.%20In%20contrast%2C%20race%2C%20ethnicity%2C%20body%20mass%20index%2C%20and%20immunocompromising%20conditions%20were%20not%20associated%20with%20plasma%20antigen%20levels.%20Plasma%20antigen%20level%20of%201000%20ng%5C%2FL%20or%20greater%20was%20associated%20with%20a%20markedly%20higher%20odds%20of%20worsened%20pulmonary%20status%20at%20day%205%20%28odds%20ratio%2C%205.06%20%5BCI%2C%203.41%20to%207.50%5D%29%20and%20longer%20time%20to%20hospital%20discharge%20%28median%2C%207%20vs.%204%20days%3B%20subhazard%20ratio%2C%200.51%20%5BCI%2C%200.45%20to%200.57%5D%29%2C%20with%20subhazard%20ratios%20similar%20across%20all%20levels%20of%20baseline%20pulmonary%20severity.%5CnLIMITATIONS%3A%20Plasma%20samples%20were%20drawn%20at%20enrollment%2C%20not%20hospital%20presentation.%20No%20point-of-care%20test%20to%20measure%20plasma%20antigen%20is%20currently%20available.%5CnCONCLUSION%3A%20Elevated%20plasma%20antigen%20is%20highly%20associated%20with%20both%20severity%20of%20pulmonary%20illness%20and%20clinically%20important%20patient%20outcomes.%20Multiple%20clinical%20and%20viral%20factors%20are%20associated%20with%20plasma%20antigen%20level%20at%20presentation.%20These%20data%20support%20a%20potential%20role%20of%20ongoing%20viral%20replication%20in%20the%20pathogenesis%20of%20SARS-CoV-2%20in%20hospitalized%20patients.%5CnPRIMARY%20FUNDING%20SOURCE%3A%20U.S.%20government%20Operation%20Warp%20Speed%20and%20National%20Institute%20of%20Allergy%20and%20Infectious%20Diseases.%22%2C%22date%22%3A%22Oct%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7326%5C%2FM22-0924%22%2C%22ISSN%22%3A%221539-3704%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%228HHBIBI6%22%2C%22849YWXRD%22%2C%22B2JSS4XR%22%2C%22QSVIJDTT%22%2C%22KXW8KUFU%22%2C%22QU9YAHAV%22%2C%22ZEQKP47S%22%2C%22F4SX9Z9X%22%2C%22FA6KSIY7%22%2C%22BULWH4DD%22%2C%22GVTR6QC3%22%5D%2C%22dateModified%22%3A%222023-02-14T20%3A20%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22PFYV7KEN%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22ACTIV-3%5C%2FTICO%20Study%20Group%20et%20al.%22%2C%22parsedDate%22%3A%222022-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BACTIV-3%5C%2FTICO%20Study%20Group%2C%20Barkauskas%2C%20C.%2C%20Mylonakis%2C%20E.%20et%20al.%20%282022%29.%20Efficacy%20and%20safety%20of%20ensovibep%20for%20adults%20hospitalized%20with%20COVID-19%3A%20a%20randomized%20controlled%20trial.%20%26lt%3Bi%26gt%3BAnn%20Intern%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B175%26lt%3B%5C%2Fi%26gt%3B%2C%201266%26%23x2013%3B1274.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7326%5C%2FM22-1503%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.7326%5C%2FM22-1503%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Efficacy%20and%20safety%20of%20ensovibep%20for%20adults%20hospitalized%20with%20COVID-19%3A%20a%20randomized%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22ACTIV-3%5C%2FTICO%20Study%20Group%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22Barkauskas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleftherios%22%2C%22lastName%22%3A%22Mylonakis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garyfallia%22%2C%22lastName%22%3A%22Poulakou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barnaby%20E.%22%2C%22lastName%22%3A%22Young%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Vock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lianne%22%2C%22lastName%22%3A%22Siegel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Engen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greg%22%2C%22lastName%22%3A%22Grandits%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nilima%20R.%22%2C%22lastName%22%3A%22Mosaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20M.%22%2C%22lastName%22%3A%22Vekstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Rogers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fadi%22%2C%22lastName%22%3A%22Shehadeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Kaczynski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evangelia%20K.%22%2C%22lastName%22%3A%22Mylona%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantinos%20N.%22%2C%22lastName%22%3A%22Syrigos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vasiliki%22%2C%22lastName%22%3A%22Rapti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20C.%22%2C%22lastName%22%3A%22Lye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diong%20Shiau%22%2C%22lastName%22%3A%22Hui%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lindsay%22%2C%22lastName%22%3A%22Leither%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirk%20U.%22%2C%22lastName%22%3A%22Knowlton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamta%20K.%22%2C%22lastName%22%3A%22Jain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rubria%22%2C%22lastName%22%3A%22Marines-Price%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Osuji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20Scott%22%2C%22lastName%22%3A%22Overcash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ioannis%22%2C%22lastName%22%3A%22Kalomenidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zafeiria%22%2C%22lastName%22%3A%22Barmparessou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Waters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karla%22%2C%22lastName%22%3A%22Zepeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%22%2C%22lastName%22%3A%22Torbati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Kiweewa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholus%22%2C%22lastName%22%3A%22Sebudde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eyad%22%2C%22lastName%22%3A%22Almasri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alyssa%22%2C%22lastName%22%3A%22Hughes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%20R.%22%2C%22lastName%22%3A%22Bhagani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alison%22%2C%22lastName%22%3A%22Rodger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uriel%22%2C%22lastName%22%3A%22Sandkovsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20L.%22%2C%22lastName%22%3A%22Gottlieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eriobu%22%2C%22lastName%22%3A%22Nnakelu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Trautner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vidya%22%2C%22lastName%22%3A%22Menon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Lutaakome%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Matthay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Robinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantinos%22%2C%22lastName%22%3A%22Protopapas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolaos%22%2C%22lastName%22%3A%22Koulouris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Kimuli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amiran%22%2C%22lastName%22%3A%22Baduashvili%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20L.%22%2C%22lastName%22%3A%22Braun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srikanth%22%2C%22lastName%22%3A%22Ramachandruni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Kidega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kami%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20J.%22%2C%22lastName%22%3A%22Hatlen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20N.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20D.%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomas%20O.%22%2C%22lastName%22%3A%22Jensen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20L.%22%2C%22lastName%22%3A%22Padilla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evan%20X.%22%2C%22lastName%22%3A%22Accardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katy%22%2C%22lastName%22%3A%22Shaw-Saliba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%20L.%22%2C%22lastName%22%3A%22Dewar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Teitelbaum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ven%22%2C%22lastName%22%3A%22Natarajan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Laverdure%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helene%20C.%22%2C%22lastName%22%3A%22Highbarger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20Tauseef%22%2C%22lastName%22%3A%22Rehman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Vogel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Vall%5Cu00e9e%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Page%22%2C%22lastName%22%3A%22Crew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Negin%22%2C%22lastName%22%3A%22Atri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%20J.%22%2C%22lastName%22%3A%22Schechner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Pett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fleur%22%2C%22lastName%22%3A%22Hudson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Badrock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giota%22%2C%22lastName%22%3A%22Touloumi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%20M.%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wesley%20H.%22%2C%22lastName%22%3A%22Self%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Crystal%20M.%22%2C%22lastName%22%3A%22North%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adit%20A.%22%2C%22lastName%22%3A%22Ginde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%20C.%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Kelleher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Nagy-Agren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shikha%22%2C%22lastName%22%3A%22Vasudeva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Looney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hien%20H.%22%2C%22lastName%22%3A%22Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adriana%22%2C%22lastName%22%3A%22S%5Cu00e1nchez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20C.%22%2C%22lastName%22%3A%22Weintrob%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Birgit%22%2C%22lastName%22%3A%22Grund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shweta%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cavan%20S.%22%2C%22lastName%22%3A%22Reilly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Paredes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnieszka%22%2C%22lastName%22%3A%22Bednarska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norman%20P.%22%2C%22lastName%22%3A%22Gerry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abdel%20G.%22%2C%22lastName%22%3A%22Babiker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victoria%20J.%22%2C%22lastName%22%3A%22Davey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annetine%20C.%22%2C%22lastName%22%3A%22Gelijns%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20S.%22%2C%22lastName%22%3A%22Higgs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginia%22%2C%22lastName%22%3A%22Kan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gail%22%2C%22lastName%22%3A%22Matthews%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20Taylor%22%2C%22lastName%22%3A%22Thompson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Legenne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richa%22%2C%22lastName%22%3A%22Chandra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20Clifford%22%2C%22lastName%22%3A%22Lane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Neaton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%20D.%22%2C%22lastName%22%3A%22Lundgren%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Ensovibep%20%28MP0420%29%20is%20a%20designed%20ankyrin%20repeat%20protein%2C%20a%20novel%20class%20of%20engineered%20proteins%2C%20under%20investigation%20as%20a%20treatment%20of%20SARS-CoV-2%20infection.%5CnOBJECTIVE%3A%20To%20investigate%20if%20ensovibep%2C%20in%20addition%20to%20remdesivir%20and%20other%20standard%20care%2C%20improves%20clinical%20outcomes%20among%20patients%20hospitalized%20with%20COVID-19%20compared%20with%20standard%20care%20alone.%5CnDESIGN%3A%20Double-blind%2C%20randomized%2C%20placebo-controlled%2C%20clinical%20trial.%20%28ClinicalTrials.gov%3A%20NCT04501978%29.%5CnSETTING%3A%20Multinational%2C%20multicenter%20trial.%5CnPARTICIPANTS%3A%20Adults%20hospitalized%20with%20COVID-19.%5CnINTERVENTION%3A%20Intravenous%20ensovibep%2C%20600%20mg%2C%20or%20placebo.%5CnMEASUREMENTS%3A%20Ensovibep%20was%20assessed%20for%20early%20futility%20on%20the%20basis%20of%20pulmonary%20ordinal%20scores%20at%20day%205.%20The%20primary%20outcome%20was%20time%20to%20sustained%20recovery%20through%20day%2090%2C%20defined%20as%2014%20consecutive%20days%20at%20home%20or%20place%20of%20usual%20residence%20after%20hospital%20discharge.%20A%20composite%20safety%20outcome%20that%20included%20death%2C%20serious%20adverse%20events%2C%20end-organ%20disease%2C%20and%20serious%20infections%20was%20assessed%20through%20day%2090.%5CnRESULTS%3A%20An%20independent%20data%20and%20safety%20monitoring%20board%20recommended%20that%20enrollment%20be%20halted%20for%20early%20futility%20after%20485%20patients%20were%20randomly%20assigned%20and%20received%20an%20infusion%20of%20ensovibep%20%28n%5Cu00a0%3D%5Cu00a0247%29%20or%20placebo%20%28n%5Cu00a0%3D%5Cu00a0238%29.%20The%20odds%20ratio%20%28OR%29%20for%20a%20more%20favorable%20pulmonary%20outcome%20in%20the%20ensovibep%20%28vs.%20placebo%29%20group%20at%20day%205%20was%200.93%20%2895%25%20CI%2C%200.67%20to%201.30%3B%20P%5Cu00a0%3D%5Cu00a00.68%3B%20OR%5Cu00a0%26gt%3B%5Cu00a01%20would%20favor%20ensovibep%29.%20The%2090-day%20cumulative%20incidence%20of%20sustained%20recovery%20was%2082%25%20for%20ensovibep%20and%2080%25%20for%20placebo%20%28subhazard%20ratio%20%5BsHR%5D%2C%201.06%20%5BCI%2C%200.88%20to%201.28%5D%3B%20sHR%5Cu00a0%26gt%3B%5Cu00a01%20would%20favor%20ensovibep%29.%20The%20primary%20composite%20safety%20outcome%20at%20day%2090%20occurred%20in%2078%20ensovibep%20participants%20%2832%25%29%20and%2070%20placebo%20participants%20%2829%25%29%20%28HR%2C%201.07%20%5BCI%2C%200.77%20to%201.47%5D%3B%20HR%5Cu00a0%26lt%3B%5Cu00a01%20would%20favor%20ensovibep%29.%5CnLIMITATION%3A%20The%20trial%20was%20prematurely%20stopped%20because%20of%20futility%2C%20limiting%20power%20for%20the%20primary%20outcome.%5CnCONCLUSION%3A%20Compared%20with%20placebo%2C%20ensovibep%20did%20not%20improve%20clinical%20outcomes%20for%20hospitalized%20participants%20with%20COVID-19%20receiving%20standard%20care%2C%20including%20remdesivir%3B%20no%20safety%20concerns%20were%20identified.%5CnPRIMARY%20FUNDING%20SOURCE%3A%20National%20Institutes%20of%20Health.%22%2C%22date%22%3A%22Sept%202022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.7326%5C%2FM22-1503%22%2C%22ISSN%22%3A%221539-3704%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%228HHBIBI6%22%2C%22849YWXRD%22%2C%22UCRZ9WV2%22%2C%22B2JSS4XR%22%2C%22QSVIJDTT%22%2C%22QU9YAHAV%22%2C%22ZEQKP47S%22%2C%22F4SX9Z9X%22%2C%22FA6KSIY7%22%2C%22BULWH4DD%22%2C%22GVTR6QC3%22%5D%2C%22dateModified%22%3A%222023-02-14T20%3A14%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22BZ47UHWD%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Angelini%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAngelini%2C%20P.%2C%20Postalian%2C%20A.%2C%20Hernandez-Vila%2C%20E.%20et%20al.%20%282022%29.%20COVID-19%20and%20the%20heart%3A%20could%20transient%20takotsubo%20cardiomyopathy%20be%20related%20to%20the%20pandemic%20by%20incidence%20and%20mechanisms%3F%20%26lt%3Bi%26gt%3BFront%20Cardiovasc%20Med%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B9%26lt%3B%5C%2Fi%26gt%3B%2C%20919715.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcvm.2022.919715%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcvm.2022.919715%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COVID-19%20and%20the%20heart%3A%20could%20transient%20takotsubo%20cardiomyopathy%20be%20related%20to%20the%20pandemic%20by%20incidence%20and%20mechanisms%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paolo%22%2C%22lastName%22%3A%22Angelini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Postalian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%22%2C%22lastName%22%3A%22Hernandez-Vila%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlo%22%2C%22lastName%22%3A%22Uribe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%22%2C%22lastName%22%3A%22Costello%22%7D%5D%2C%22abstractNote%22%3A%22Typical%20emergency%20hospital%20care%20during%20the%20COVID-19%20pandemic%20has%20centered%20on%20pulmonary-focused%20services.%20Nonetheless%2C%20patients%20with%20COVID-19%20frequently%20develop%20complications%20associated%20with%20the%20dysfunction%20of%20other%20organs%2C%20which%20may%20greatly%20affect%20prognosis.%20Preliminary%20evidence%20suggests%20that%20cardiovascular%20involvement%20is%20relatively%20frequent%20in%20COVID-19%20and%20that%20it%20correlates%20with%20significant%20worsening%20of%20clinical%20status%20and%20mortality%20in%20infected%20patients.%20In%20this%20article%2C%20we%20summarize%20current%20knowledge%20on%20the%20cardiovascular%20effects%20of%20COVID-19.%20In%20particular%2C%20we%20focus%20on%20the%20association%20between%20COVID-19%20and%20transient%20takotsubo%20cardiomyopathy%20%28TTC%29-two%20conditions%20that%20preliminarily%20seem%20epidemiologically%20associated-and%20we%20highlight%20cardiovascular%20changes%20that%20may%20help%20guide%20future%20investigations%20toward%20full%20discovery%20of%20this%20new%2C%20complex%20disease%20entity.%20We%20hypothesize%20that%20coronary%20endothelial%20dysfunction%2C%20along%20with%20septic%20state%2C%20inflammatory%20storm%2C%20hypercoagulability%2C%20endothelial%20necrosis%2C%20and%20small-vessel%20clotting%2C%20may%20represent%20a%20fundamental%20hidden%20link%20between%20COVID-19%20and%20TTC.%20Furthermore%2C%20given%20the%20likelihood%20that%20new%20genetic%20mutations%20of%20coronaviruses%20or%20other%20organisms%20will%20cause%20similar%20pandemics%20and%20endemics%20in%20the%20future%2C%20we%20must%20be%20better%20prepared%20so%20that%20a%20substantial%20complication%20such%20as%20TTC%20can%20be%20more%20accurately%20recognized%2C%20its%20pathophysiology%20better%20understood%2C%20and%20its%20treatment%20made%20more%20justifiable%2C%20timely%2C%20and%20effective.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcvm.2022.919715%22%2C%22ISSN%22%3A%222297-055X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22UJCYSTVM%22%2C%22M5BIXWLJ%22%2C%22849YWXRD%22%2C%22MXKXGRC3%22%2C%22QSVIJDTT%22%2C%228PULYTSK%22%2C%222RCWVZ4F%22%5D%2C%22dateModified%22%3A%222022-08-01T21%3A56%3A01Z%22%7D%7D%2C%7B%22key%22%3A%225EH5PNVH%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Postalian%20et%20al.%22%2C%22parsedDate%22%3A%222021-09-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPostalian%2C%20A.%2C%20Strickman%2C%20N.%20E.%2C%20%26lt%3Bstrong%26gt%3BCostello%26lt%3B%5C%2Fstrong%26gt%3B%2C%20B.%20T.%20et%20al.%20%282021%29.%20%26%23x201C%3BSimple%26%23x201D%3B%20transcatheter%20aortic%20valve%20replacement%20with%20conscious%20sedation%3A%20Safety%20and%20effectiveness%20in%20real-world%20practice.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B48%26lt%3B%5C%2Fi%26gt%3B%2C%20e207528.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.10453%5C%2FTHIJ-20-7528%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.10453%5C%2FTHIJ-20-7528%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5C%22Simple%5C%22%20transcatheter%20aortic%20valve%20replacement%20with%20conscious%20sedation%3A%20Safety%20and%20effectiveness%20in%20real-world%20practice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Postalian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neil%20E.%22%2C%22lastName%22%3A%22Strickman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%20T.%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%20G.%22%2C%22lastName%22%3A%22Dougherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%5D%2C%22abstractNote%22%3A%22Transcatheter%20aortic%20valve%20replacement%20%28TAVR%29%20is%20a%20well-established%20alternative%20to%20open%20surgical%20replacement.%20Strictly%20selecting%20low-risk%20patients%20and%20using%20conscious%20sedation%20during%20TAVR%20has%20enabled%20hospital%20stays%20to%20be%20safely%20shortened.%20We%20evaluated%20the%20safety%20and%20effectiveness%20of%20a%20less%20rigorous%20patient-selection%20process%20involving%20multidisciplinary%20case%20discussions%2C%20percutaneous%20procedures%20with%20the%20use%20of%20conscious%20sedation%2C%20and%20postprocedural%20care%20outside%20an%20intensive%20care%20unit%2C%20with%20the%20goal%20of%20discharging%20patients%20from%20the%20hospital%20early.%20We%20call%20this%20%26quot%3Bsimple%20TAVR.%26quot%3B%20We%20retrospectively%20reviewed%20the%20records%20of%20patients%20who%20underwent%20TAVR%20from%20March%202015%20through%20February%202020%20at%20our%20center.%20The%20procedures%20were%20performed%20by%202%20high-volume%20operators.%20Of%20524%20total%20procedures%2C%20344%20%2865.6%25%29%20qualified%20as%20simple%20TAVR.%20All%20344%20procedures%20were%20successful.%20The%20highest%2030-day%20complication%20rate%20was%20associated%20with%20new%20permanent%20pacemaker%20implantation%20%287.3%25%2C%2025%20patients%29%3B%20the%20rates%20of%20major%20vascular%20complications%2C%20stroke%2C%20and%20all-cause%20death%20were%20less%20than%203%25%20each.%20Of%20note%2C%20252%20patients%20%2873.3%25%29%20were%20discharged%20from%20the%20hospital%20the%20day%20after%20TAVR%2C%20and%20307%20%2889.2%25%29%20within%2048%20hours.%20Simple%20TAVR%20is%20safe%2C%20economical%2C%20and%20feasible%20in%20real-world%20practice%2C%20and%20it%20does%20not%20necessitate%20a%20rigorous%20perioperative%20protocol%20or%20patient-selection%20process.%22%2C%22date%22%3A%22Sept%2001%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.10453%5C%2FTHIJ-20-7528%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%223WHLRQCH%22%2C%22YQ6XGPLC%22%2C%22849YWXRD%22%2C%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-10-29T19%3A44%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22EFZ9YY7A%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kherallah%20et%20al.%22%2C%22parsedDate%22%3A%222021-09%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKherallah%2C%20R.%20Y.%2C%20Koneru%2C%20S.%2C%20Krajcer%2C%20Z.%20et%20al.%20%282021%29.%20Hemodynamic%20outcomes%20after%20valve-in-valve%20transcatheter%20aortic%20valve%20replacement%3A%20a%20single-center%20experience.%20%26lt%3Bi%26gt%3BAnn%20Cardiothorac%20Surg%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%2C%20630%26%23x2013%3B640.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21037%5C%2Facs-2021-tviv-131%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21037%5C%2Facs-2021-tviv-131%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hemodynamic%20outcomes%20after%20valve-in-valve%20transcatheter%20aortic%20valve%20replacement%3A%20a%20single-center%20experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20Yazan%22%2C%22lastName%22%3A%22Kherallah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srikanth%22%2C%22lastName%22%3A%22Koneru%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ourania%22%2C%22lastName%22%3A%22Preventza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%20G.%22%2C%22lastName%22%3A%22Dougherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20L.%22%2C%22lastName%22%3A%22McCormack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%20T.%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Coulter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neil%20E.%22%2C%22lastName%22%3A%22Strickman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Carlos%22%2C%22lastName%22%3A%22Plana%20Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Mortazavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20G.%22%2C%22lastName%22%3A%22D%5Cu00edez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20J.%22%2C%22lastName%22%3A%22Livesay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20S.%22%2C%22lastName%22%3A%22Coselli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20V.%22%2C%22lastName%22%3A%22Silva%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Sept%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.21037%5C%2Facs-2021-tviv-131%22%2C%22ISSN%22%3A%222225319X%2C%2023041021%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.annalscts.com%5C%2Farticle%5C%2Fview%5C%2F16858%5C%2Fhtml%22%2C%22collections%22%3A%5B%22DV9ZHE2J%22%2C%223WHLRQCH%22%2C%22SQD2CTYV%22%2C%22BJSZ96GT%22%2C%22YL3LPZGE%22%2C%22Z2XX7DHR%22%2C%22M32R8FP2%22%2C%22YQ6XGPLC%22%2C%22RB8ZRZCJ%22%2C%222K4N54U2%22%2C%22QSVIJDTT%22%2C%22MZXU6P62%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222022-05-12T20%3A43%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22U7JN8NMM%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Khandelwal%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-04%22%2C%22numChildren%22%3A6%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKhandelwal%2C%20A.%2C%20Bakir%2C%20M.%2C%20Bezaire%2C%20M.%20et%20al.%20%282021%29.%20Managing%20ischemic%20heart%20disease%20in%20women%3A%20Role%20of%20a%20women%26%23x2019%3Bs%20heart%20center.%20%26lt%3Bi%26gt%3BCurr%20Atheroscler%20Rep%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%2C%2056.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11883-021-00956-x%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11883-021-00956-x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Managing%20ischemic%20heart%20disease%20in%20women%3A%20Role%20of%20a%20women%27s%20heart%20center%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abha%22%2C%22lastName%22%3A%22Khandelwal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22May%22%2C%22lastName%22%3A%22Bakir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meghan%22%2C%22lastName%22%3A%22Bezaire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joanne%20Michelle%20D.%22%2C%22lastName%22%3A%22Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerie%22%2C%22lastName%22%3A%22Hoover%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noreen%20T.%22%2C%22lastName%22%3A%22Nazir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22Nichols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%22%2C%22lastName%22%3A%22Reisenberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anupama%22%2C%22lastName%22%3A%22Rao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rupa%22%2C%22lastName%22%3A%22Sanghani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Tracy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annabelle%20Santos%22%2C%22lastName%22%3A%22Volgman%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%20OF%20REVIEW%3A%20Heart%20centers%20for%20women%20%28HCW%29%20were%20developed%20due%20to%20the%20rising%20cardiovascular%20morbidity%20and%20mortality%20in%20women%20in%20the%20United%20States%20in%20the%20early%201990s.%20Our%20review%20encompasses%20the%20epidemiology%2C%20risk%20factors%2C%20diagnostic%20strategies%2C%20treatments%2C%20and%20the%20role%20of%20HCW%20in%20managing%20women%20with%20ischemic%20heart%20disease%20%28IHD%29.%5CnRECENT%20FINDINGS%3A%20HCW%20use%20a%20multidisciplinary%20team%20to%20manage%20women%20with%20IHD.%20Due%20to%20the%20paucity%20of%20randomized%20controlled%20trials%20investigating%20various%20manifestations%20of%20IHD%2C%20some%20treatments%20are%20not%20evidence-based%20such%20as%20those%20for%20coronary%20microvascular%20dysfunction%20and%20spontaneous%20coronary%20artery%20dissection.%20Sex-specific%20risk%20factors%20have%20been%20identified%20and%20multimodality%20cardiac%20imaging%20is%20improving%20in%20diagnosing%20IHD%20in%20women.%20Treatments%20are%20being%20studied%20to%20help%20improve%20symptoms%20and%20outcomes%20in%20women%20with%20IHD.%20There%20has%20been%20progress%20in%20the%20care%20of%20women%20with%20IHD.%20HCW%20can%20be%20instrumental%20in%20treating%20women%20with%20IHD%2C%20doing%20research%2C%20and%20being%20a%20source%20of%20research%20study%20participants.%22%2C%22date%22%3A%22Aug%204%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11883-021-00956-x%22%2C%22ISSN%22%3A%221534-6242%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-09-27T20%3A04%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22K43TK2NP%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Costello%20and%20Krajcer%22%2C%22parsedDate%22%3A%222021-06-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BCostello%26lt%3B%5C%2Fstrong%26gt%3B%2C%20B.%20T.%20and%20Krajcer%2C%20Z.%20%282021%29.%20Editorial%20Comments%20for%3A%20%26%23x201C%3BTranscatheter%20valve-in-valve%20implantation%20versus%20surgical%20redo%20aortic%20root%20replacement%20in%20patients%20with%20degenerated%20freestyle%20aortic%20bioprosthesis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BCatheter%20Cardiovasc%20Interv%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B97%26lt%3B%5C%2Fi%26gt%3B%2C%201479%26%23x2013%3B1480.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29762%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29762%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Editorial%20Comments%20for%3A%20%5C%22Transcatheter%20valve-in-valve%20implantation%20versus%20surgical%20redo%20aortic%20root%20replacement%20in%20patients%20with%20degenerated%20freestyle%20aortic%20bioprosthesis%5C%22%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%20T.%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Jun%201%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fccd.29762%22%2C%22ISSN%22%3A%221522-726X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%223WHLRQCH%22%2C%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-07-20T19%3A47%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22P2BUG2LZ%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Krajcer%20and%20Costello%22%2C%22parsedDate%22%3A%222021-01-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKrajcer%2C%20Z.%20and%20%26lt%3Bstrong%26gt%3BCostello%26lt%3B%5C%2Fstrong%26gt%3B%2C%20B.%20%282021%29.%20Clinical%20impact%20of%20calcified%20nodules%20in%20patients%20with%20heavily%20calcified%20lesions%20requiring%20rotational%20atherectomy.%20%26lt%3Bi%26gt%3BCatheter%20Cardiovasc%20Interv%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B97%26lt%3B%5C%2Fi%26gt%3B%2C%2020%26%23x2013%3B21.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29450%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29450%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Clinical%20impact%20of%20calcified%20nodules%20in%20patients%20with%20heavily%20calcified%20lesions%20requiring%20rotational%20atherectomy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%22%2C%22lastName%22%3A%22Costello%22%7D%5D%2C%22abstractNote%22%3A%22Coronary%20atherectomy%20has%20been%20around%20for%20many%20years%2C%20and%20the%20body%20of%20evidence%20for%20its%20use%20in%20complex%20calcified%20lesions%20has%20grown.%20Calcific%20coronary%20disease%20presents%20a%20particularly%20challenging%20clinical%20scenario%20in%20PCI%2C%20having%20poorer%20outcomes%20than%20noncalcified%20lesions.%20This%20study%20is%20the%20first%20to%20identify%20calcified%20nodules%20as%20an%20independent%20predictor%20of%20worse%20outcomes%20after%20atherectomy%20and%20PCI.%20Continued%20study%20of%20lesion%20characteristics%20will%20improve%20our%20understanding%20of%20PCI%20outcomes%20and%20help%20manage%20patients%20in%20the%20long-term%20after%20PCI%20and%20stenting.%22%2C%22date%22%3A%22Jan%201%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fccd.29450%22%2C%22ISSN%22%3A%221522-726X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%223WHLRQCH%22%2C%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-02-11T18%3A20%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22WVBQ6VRU%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mihailidou%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMihailidou%2C%20A.%20S.%2C%20McCall%2C%20D.%2C%20Hiremath%2C%20S.%20et%20al.%20%282021%29.%20Use%20of%20social%20media%20at%20cardiovascular%20congresses%3A%20Opportunities%20for%20education%20and%20dissemination.%20%26lt%3Bi%26gt%3BCurr%20Cardiol%20Rev%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B17%26lt%3B%5C%2Fi%26gt%3B%2C%20129%26%23x2013%3B136.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2174%5C%2F1573403X16666200206103328%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2174%5C%2F1573403X16666200206103328%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Use%20of%20social%20media%20at%20cardiovascular%20congresses%3A%20Opportunities%20for%20education%20and%20dissemination%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastashia%20S.%22%2C%22lastName%22%3A%22Mihailidou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debbe%22%2C%22lastName%22%3A%22McCall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Swapnil%22%2C%22lastName%22%3A%22Hiremath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%22%2C%22lastName%22%3A%22Costello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anuradha%22%2C%22lastName%22%3A%22Tunuguntla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harris%22%2C%22lastName%22%3A%22Mihailidis%22%7D%5D%2C%22abstractNote%22%3A%22Social%20Media%20includes%20different%20forms%20of%20online%20communication%20from%20Twitter%2C%20Facebook%2C%20Instagram%2C%20LinkedIn%2C%20podcasts%2C%20YouTube%20etc.%20and%20has%20advanced%20how%20information%20is%20exchanged.%20A%20notable%20use%20is%20engaging%20on%20Twitter%20at%20medical%20conferences%2C%20both%20for%20those%20attending%20the%20conference%20and%20the%20global%20audience%20who%20are%20not%20able%20to%20attend.%20It%20is%20also%20increasingly%20used%20as%20an%20educational%20tool%20similar%20to%20e-learning.%20The%20objective%20of%20this%20paper%20is%20to%3A%201%29%20highlight%20the%20impact%20of%20using%20Twitter%20at%20cardiovascular%20congresses%20as%20an%20interactive%20platform%20for%20active%20learning%20as%20compared%20to%20passively%20listening%20to%20a%20presentation%3B%202%29%20present%20perspectives%20from%20not%20only%20clinicians%2C%20researchers%20but%20also%20patients%20on%20how%20this%20information%20is%20interpreted%3B%203%29%20provide%20recommendations%20for%20conference%20organizers%20for%20best%20practice%20live%20tweeting%20to%20share%20the%20information%20and%20knowledge%20beyond%20those%20in%20attendance%3B%20with%20potential%20for%20not%20only%20engagement%20but%20also%20educating%20our%20global%20community.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.2174%5C%2F1573403X16666200206103328%22%2C%22ISSN%22%3A%221875-6557%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-07-20T19%3A13%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22R6RU9RCN%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Krajcer%20and%20Costello%22%2C%22parsedDate%22%3A%222020-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKrajcer%2C%20Z.%20and%20%26lt%3Bstrong%26gt%3BCostello%26lt%3B%5C%2Fstrong%26gt%3B%2C%20B.%20%282020%29.%20Effect%20of%20concomitant%20aortic%20regurgitation%20on%20early%20hypoattenuated%20leaflet%20thickening%20after%20transcatheter%20aortic%20valve%20replacement%20in%20patients%20with%20symptomatic%20severe%20aortic%20stenosis.%20%26lt%3Bi%26gt%3BCatheter%20Cardiovasc%20Interv%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B96%26lt%3B%5C%2Fi%26gt%3B%2C%201498%26%23x2013%3B1499.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29409%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fccd.29409%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20concomitant%20aortic%20regurgitation%20on%20early%20hypoattenuated%20leaflet%20thickening%20after%20transcatheter%20aortic%20valve%20replacement%20in%20patients%20with%20symptomatic%20severe%20aortic%20stenosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Briana%22%2C%22lastName%22%3A%22Costello%22%7D%5D%2C%22abstractNote%22%3A%22Identification%20of%20hypoattenuated%20leaflet%20thickening%20%28HALT%29%20and%20subacute%20leaflet%20thrombosis%20has%20become%20widely%20recognized.%20Patients%20with%20anatomical%20changes%20associated%20with%20moderate%20or%20greater%20aortic%20regurgitation%20%28larger%20sinus%20of%20Valsalva%20and%20eccentric%20left%20ventricular%20remodeling%29%20appear%20to%20have%20less%20HALT%20early%20postprocedure%20compared%20with%20those%20without.%20Further%20research%20on%20the%20risk%20factors%20including%20anatomical%20and%20hemodynamic%20variables%20should%20further%20our%20knowledge%20of%20these%20entities%20so%20we%20can%20better%20manage%20patient%20both%20pre%20and%20post%20TAVR.%22%2C%22date%22%3A%22Dec%202020%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fccd.29409%22%2C%22ISSN%22%3A%221522-726X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%223WHLRQCH%22%2C%22QSVIJDTT%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-01-07T19%3A51%3A11Z%22%7D%7D%5D%7D
ACTIV-3/TICO Study Group, Rogers, A. J., Wentworth, D. et al. (2022). The association of baseline plasma sars-cov-2 nucleocapsid antigen level and outcomes in patients hospitalized with COVID-19. Ann Intern Med 175, 1401–1410. https://doi.org/10.7326/M22-0924.
ACTIV-3/TICO Study Group, Barkauskas, C., Mylonakis, E. et al. (2022). Efficacy and safety of ensovibep for adults hospitalized with COVID-19: a randomized controlled trial. Ann Intern Med 175, 1266–1274. https://doi.org/10.7326/M22-1503.
Angelini, P., Postalian, A., Hernandez-Vila, E. et al. (2022). COVID-19 and the heart: could transient takotsubo cardiomyopathy be related to the pandemic by incidence and mechanisms? Front Cardiovasc Med 9, 919715. https://doi.org/10.3389/fcvm.2022.919715.
Postalian, A., Strickman, N. E., Costello, B. T. et al. (2021). “Simple” transcatheter aortic valve replacement with conscious sedation: Safety and effectiveness in real-world practice. Tex Heart Inst J 48, e207528. https://doi.org/10.10453/THIJ-20-7528.
Kherallah, R. Y., Koneru, S., Krajcer, Z. et al. (2021). Hemodynamic outcomes after valve-in-valve transcatheter aortic valve replacement: a single-center experience. Ann Cardiothorac Surg 10, 630–640. https://doi.org/10.21037/acs-2021-tviv-131.
Khandelwal, A., Bakir, M., Bezaire, M. et al. (2021). Managing ischemic heart disease in women: Role of a women’s heart center. Curr Atheroscler Rep 23, 56. https://doi.org/10.1007/s11883-021-00956-x.
Costello, B. T. and Krajcer, Z. (2021). Editorial Comments for: “Transcatheter valve-in-valve implantation versus surgical redo aortic root replacement in patients with degenerated freestyle aortic bioprosthesis.” Catheter Cardiovasc Interv 97, 1479–1480. https://doi.org/10.1002/ccd.29762.
Krajcer, Z. and Costello, B. (2021). Clinical impact of calcified nodules in patients with heavily calcified lesions requiring rotational atherectomy. Catheter Cardiovasc Interv 97, 20–21. https://doi.org/10.1002/ccd.29450.
Mihailidou, A. S., McCall, D., Hiremath, S. et al. (2021). Use of social media at cardiovascular congresses: Opportunities for education and dissemination. Curr Cardiol Rev 17, 129–136. https://doi.org/10.2174/1573403X16666200206103328.
Krajcer, Z. and Costello, B. (2020). Effect of concomitant aortic regurgitation on early hypoattenuated leaflet thickening after transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis. Catheter Cardiovasc Interv 96, 1498–1499. https://doi.org/10.1002/ccd.29409.

Recent News

Celebrating National Women Physicians Day

On February 3rd, we humbly pay tribute to the tremendous strides made by female doctors as we proudly celebrate National...

American Heart Month 2024: Celebrate with The Texas Heart Institute

February is American Heart Month – a time for the nation to cooperatively focus on heart health and lifestyle choices...

Girl Scouts Project Heart 2024 STEM Innovation Day with The Texas Heart Institute…and Cool-E

The Texas Heart Institute to Host Brownie & Junior Girl Scouts to Earn Project Heart Smart Patch The Texas Heart...