Brent Gudenkauf, MD
See Publications

Texas Heart Institute Positions

Education

  • Undergraduate:

    Cornell University

  • Medical School:

    Texas Tech University Health Sciences Center School of Medicine

  • Residency:

    Osler Medical Residency, Johns Hopkins Hospital

Publications

4862227 YALQMD8B 1 alternatives-to-animal-experimentation 10 date desc Gudenkauf 53143 https://www.texasheart.org/wp-content/plugins/zotpress/
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Gudenkauf, B., Shaya, G., Mukherjee, M. et al. (2023). Insulin resistance is associated with subclinical myocardial dysfunction and reduced functional capacity in heart failure with preserved ejection fraction. J Cardiol, S0914-5087(23)00153–3. https://doi.org/10.1016/j.jjcc.2023.06.008.
Ahmad, Y., Gaston, D. C., Gray, J. et al. (2022). Closing the Brief Case: The Fly Who Cried Wohlf. J Clin Microbiol 60, e0108121. https://doi.org/10.1128/jcm.01081-21.
Ahmad, Y., Gaston, D. C., Gray, J. et al. (2022). The Brief Case: The Fly Who Cried Wohlf. J Clin Microbiol 60, e0107321. https://doi.org/10.1128/jcm.01073-21.
Kazzi, B., Gudenkauf, B., Fine, D. et al. (2022). Adalimumab-Induced Lupus Nephritis: Case Report and Review of the Literature. Eur J Rheumatol 9, 108–110. https://doi.org/10.5152/eurjrheum.2022.21059.
Gudenkauf, B., Hays, A. G., Tamis-Holland, J. et al. (2022). Role of Multimodality Imaging in the Assessment of Myocardial Infarction With Nonobstructive Coronary Arteries: Beyond Conventional Coronary Angiography. J Am Heart Assoc 11, e022787. https://doi.org/10.1161/JAHA.121.022787.
Gudenkauf, B., Goetsch, M. R., Vakil, R. M. et al. (2022). Case Report: Steroid-Responsive Takotsubo Cardiomyopathy Associated With Cytokine Storm and Obstructive Shock. Front Cardiovasc Med 9, 931070. https://doi.org/10.3389/fcvm.2022.931070.
Martinez, S., Garcia, J. G., Williams, R. et al. (2020). Lactobacilli spp.: real-time evaluation of biofilm growth. BMC Microbiol 20, 64. https://doi.org/10.1186/s12866-020-01753-3.
Douthit, C., Gudenkauf, B., Hamood, A. et al. (2020). Effects of powdered rifampin and vancomycin solutions on biofilm production of staphylococcus aureus on orthopedic implants. J Clin Orthop Trauma 11, S113–S117. https://doi.org/10.1016/j.jcot.2019.10.002.
Karmouty-Quintana, H., Molina, J. G., Philip, K. et al. (2018). The Antifibrotic Effect of A2B Adenosine Receptor Antagonism in a Mouse Model of Dermal Fibrosis. Arthritis Rheumatol 70, 1673–1684. https://doi.org/10.1002/art.40554.
Gudenkauf, B. M. and Hewson, I. (2015). Metatranscriptomic Analysis of Pycnopodia helianthoides (Asteroidea) Affected by Sea Star Wasting Disease. PLoS One 10, e0128150. https://doi.org/10.1371/journal.pone.0128150.