R. David Fish, MD

Dr. R. David Fish is board-certified in Internal Medicine, Cardiovascular Disease and Interventional Cardiology, and currently serves on the teaching staff of The Texas Heart Institute’s Interventional Cardiovascular Fellowship Program and the Cardiovascular Disease Fellowship Program at Baylor St. Luke’s Medical Center. He received his MD from The University of Texas Southwestern in Dallas and went on to complete his internal medicine residency at Massachusetts General Hospital in Boston. He continued his subspecialty training in cardiovascular disease at Brigham and Women’s Hospital in Boston. Over the course of his career, he has remained a leader in the field of coronary stenting, PFO and ASD closure, heart valve disease, and percutaneous heart valve replacement.

See Publications

Texas Heart Institute Positions

Education

  • Medical School:

    The University of Texas Southwestern Medical School

  • Internship:

    Massachusetts General Hospital

  • Residency:

    Massachusetts General Hospital

  • Fellowships:

    Brigham and Women's Hospital

Honors, Awards and Memberships

Publications

4862227 YRK99JHR 1 alternatives-to-animal-experimentation 10 date desc Fish 1098 https://www.texasheart.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22U6TGVYK7%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Perin%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPerin%2C%20E.%20C.%2C%20Borow%2C%20K.%20M.%2C%20Henry%2C%20T.%20D.%20et%20al.%20%282023%29.%20Randomized%20trial%20of%20targeted%20transendocardial%20mesenchymal%20precursor%26%23xA0%3Bcell%20therapy%20in%20patients%20with%26%23xA0%3Bheart%26%23xA0%3Bfailure.%20%26lt%3Bi%26gt%3BJ%20Am%20Coll%20Cardiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B81%26lt%3B%5C%2Fi%26gt%3B%2C%20849%26%23x2013%3B863.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacc.2022.11.061%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacc.2022.11.061%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Randomized%20trial%20of%20targeted%20transendocardial%20mesenchymal%20precursor%5Cu00a0cell%20therapy%20in%20patients%20with%5Cu00a0heart%5Cu00a0failure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emerson%20C.%22%2C%22lastName%22%3A%22Perin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20M.%22%2C%22lastName%22%3A%22Borow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20D.%22%2C%22lastName%22%3A%22Henry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farrell%20O.%22%2C%22lastName%22%3A%22Mendelsohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20W.%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Swiggum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20D.%22%2C%22lastName%22%3A%22Adler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20H.%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Bouchard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margaret%22%2C%22lastName%22%3A%22Jenkins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alex%22%2C%22lastName%22%3A%22Yaroshinsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%22%2C%22lastName%22%3A%22Hayes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Rutman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20W.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Rose%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silviu%22%2C%22lastName%22%3A%22Itescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barry%22%2C%22lastName%22%3A%22Greenberg%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Mesenchymal%20precursor%20cells%20%28MPCs%29%20are%20allogeneic%2C%20immunoselected%20cells%20with%20anti-inflammatory%20properties%20that%20could%20improve%20outcomes%20in%20heart%20failure%20with%20reduced%20ejection%20fraction%20%28HFrEF%29.%5CnOBJECTIVES%3A%20This%20study%20assessed%20the%20efficacy%20and%20safety%20of%20MPCs%20in%20patients%20with%20high-risk%20HFrEF.%5CnMETHODS%3A%20This%20randomized%2C%20double-blind%2C%20multicenter%20study%20evaluated%20a%20single%20transendocardial%20administration%20procedure%20of%20MPCs%20or%20sham-control%20in%20565%20intention-to-treat%20patients%20with%20HFrEF%20on%20guideline-directed%20therapies.%20The%20primary%20endpoint%20was%20time-to-recurrent%20events%20caused%20by%20decompensated%20HFrEF%20or%20successfully%20resuscitated%20symptomatic%20ventricular%20arrhythmias.%20Hierarchical%20secondary%20endpoints%20included%20components%20of%20the%20primary%20endpoint%2C%20time-to-first%20terminal%20cardiac%20events%2C%20and%20all-cause%20death.%20Separate%20and%20composite%20major%20adverse%20cardiovascular%20events%20analyses%20were%20performed%20for%20myocardial%20infarction%20or%20stroke%20or%20cardiovascular%20death.%20Baseline%20and%2012-month%20echocardiography%20was%20performed.%20Baseline%20plasma%20high-sensitivity%20C-reactive%20protein%20levels%20were%20evaluated%20for%20disease%20severity.%5CnRESULTS%3A%20The%20primary%20endpoint%20was%20similar%20between%20treatment%20groups%20%28HR%3A%201.17%3B%2095%25%5Cu00a0CI%3A%200.81-1.69%3B%20P%20%3D%200.41%29%20as%20were%20terminal%20cardiac%20events%20and%20secondary%20endpoints.%20Compared%20with%20control%20subjects%2C%20MPCs%20increased%20left%20ventricular%20ejection%20fraction%20from%20baseline%20to%2012%5Cu00a0months%2C%20especially%20in%20patients%20with%20inflammation.%20MPCs%20decreased%20the%20risk%20of%20myocardial%20infarction%20or%20stroke%20by%2058%25%20%28HR%3A%200.42%3B%2095%25%5Cu00a0CI%3A%200.23-0.76%29%20and%20the%20risk%20of%203-point%20major%20adverse%20cardiovascular%20events%20by%2028%25%20%28HR%3A%200.72%3B%2095%25%5Cu00a0CI%3A%200.51-1.03%29%20in%20the%20analysis%20population%20%28n%5Cu00a0%3D%5Cu00a0537%29%2C%20and%20by%2075%25%20%28HR%3A%200.25%3B%2095%25%5Cu00a0CI%3A%200.09-0.66%29%20and%2038%25%20%28HR%3A%200.62%3B%2095%25%5Cu00a0CI%3A%200.39-1.00%29%2C%20respectively%2C%20in%20patients%20with%20inflammation%20%28baseline%20high-sensitivity%20C-reactive%20protein%20%5Cu22652%5Cu00a0mg%5C%2FL%29.%5CnCONCLUSIONS%3A%20The%20primary%20and%20secondary%20endpoints%20of%20the%20trial%20were%20negative.%20Positive%20signals%20in%20prespecified%2C%20and%20post%20hoc%20exploratory%20analyses%20suggest%20MPCs%20may%20improve%20outcomes%2C%20especially%20in%20patients%20with%20inflammation.%22%2C%22date%22%3A%222023-03-07%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jacc.2022.11.061%22%2C%22ISSN%22%3A%221558-3597%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%228HHBIBI6%22%2C%22BNSCCUCI%22%5D%2C%22dateModified%22%3A%222023-06-08T14%3A13%3A49Z%22%7D%7D%2C%7B%22key%22%3A%223SXXRRI8%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kherallah%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKherallah%2C%20R.%20Y.%2C%20Harrison%2C%20D.%2C%20Preventza%2C%20O.%20et%20al.%20%282021%29.%20Transcatheter%20aortic%20valve%20replacement%20after%20chest%20radiation%3A%20A%20propensity-matched%20analysis.%20%26lt%3Bi%26gt%3BInt%20J%20Cardiol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B329%26lt%3B%5C%2Fi%26gt%3B%2C%2050%26%23x2013%3B55.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijcard.2020.12.054%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijcard.2020.12.054%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transcatheter%20aortic%20valve%20replacement%20after%20chest%20radiation%3A%20A%20propensity-matched%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Riyad%20Y.%22%2C%22lastName%22%3A%22Kherallah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darren%22%2C%22lastName%22%3A%22Harrison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ourania%22%2C%22lastName%22%3A%22Preventza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20V.%22%2C%22lastName%22%3A%22Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%20G.%22%2C%22lastName%22%3A%22Dougherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20A.%22%2C%22lastName%22%3A%22Coulter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leo%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Neil%20E.%22%2C%22lastName%22%3A%22Strickman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ali%22%2C%22lastName%22%3A%22Mortazavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Palaskas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%20D.%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20F.%22%2C%22lastName%22%3A%22Stainback%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Carlos%20Plana%22%2C%22lastName%22%3A%22Gomez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20J.%22%2C%22lastName%22%3A%22Livesay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20S.%22%2C%22lastName%22%3A%22Coselli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Srikanth%22%2C%22lastName%22%3A%22Koneru%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Chest%20radiation%20therapy%20%28CRT%29%20for%20malignant%20thoracic%20neoplasms%20is%20associated%20with%20development%20of%20valvular%20heart%20disease%20years%20later.%20As%20previous%20radiation%20exposure%20can%20complicate%20surgical%20treatment%2C%20transcatheter%20aortic%20valve%20replacement%20%28TAVR%29%20has%20emerged%20as%20an%20alternative.%20However%2C%20outcomes%20data%20are%20lacking%20for%20TAVR%20patients%20with%20a%20history%20of%20CRT.%5CnMETHODS%3A%20We%20conducted%20a%20retrospective%20study%20of%20all%20patients%20who%20underwent%20a%20TAVR%20procedure%20at%20a%20single%20institution%20between%20September%202012%20and%20November%202018.%20Among%201341%20total%20patients%2C%2050%20had%20previous%20CRT.%20These%20were%20propensity-matched%20in%20a%201%3A2%20ratio%20to%20100%20patients%20without%20history%20of%20CRT.%20Thirty-day%20adverse%20events%20were%20analyzed%20with%20generalized%20estimating%20equation%20models.%20Overall%20mortality%20was%20analyzed%20with%20stratified%20Cox%20regression%20modelling.%5CnRESULTS%3A%20Median%20clinical%20follow-up%20was%2024%5Cu00a0months%20%28interquartile%20range%20%5BIQR%5D%2C%2012-44%5Cu00a0months%29.%20There%20was%20no%20difference%20between%20CRT%20and%20non-CRT%20patients%20in%20overall%20mortality%20%28hazard%20ratio%20%5BHR%5D%200.84%20%5B0.37-1.90%5D%2C%20P%5Cu00a0%3D%5Cu00a00.67%29%2C%2030-day%20mortality%20%28HR%203.1%20%5B0.49-20.03%5D%2C%20P%5Cu00a0%3D%5Cu00a00.23%29%2C%20or%2030-day%20readmission%20rate%20%28HR%201.0%20%5B0.43-2.31%5D%2C%20P%5Cu00a0%3D%5Cu00a01%29.%20There%20were%20no%20differences%20in%20the%20rates%20of%20most%20adverse%20events%2C%20but%20patients%20with%20CRT%20history%20had%20higher%20rates%20of%20postprocedural%20respiratory%20failure%20%28HR%203.63%20%5B1.32-10.02%5D%2C%20P%5Cu00a0%3D%5Cu00a00.01%29%20and%20permanent%20pacemaker%20implantation%20%28HR%202.84%20%5B1.15-7.01%5D%2C%20P%5Cu00a0%3D%5Cu00a00.02%29.%5CnCONCLUSIONS%3A%20For%20patients%20with%20aortic%20valve%20stenosis%20and%20previous%20CRT%2C%20TAVR%20is%20safe%20and%20effective%2C%20with%20outcomes%20similar%20to%20those%20in%20the%20general%20aortic%20stenosis%20population.%20Patients%20with%20history%20of%20CRT%20are%20more%20likely%20to%20have%20postprocedural%20respiratory%20failure%20and%20to%20require%20permanent%20pacemaker%20implantation.%22%2C%22date%22%3A%22Apr%2015%2C%202021%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijcard.2020.12.054%22%2C%22ISSN%22%3A%221874-1754%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22DV9ZHE2J%22%2C%223WHLRQCH%22%2C%22SQD2CTYV%22%2C%22BJSZ96GT%22%2C%22YRK99JHR%22%2C%22Z2XX7DHR%22%2C%22M32R8FP2%22%2C%22AAQ89W3S%22%2C%22X6Y3USZ6%22%2C%22YQ6XGPLC%22%2C%22RB8ZRZCJ%22%2C%222K4N54U2%22%2C%22MZXU6P62%22%2C%228PULYTSK%22%2C%22MDTREPAF%22%5D%2C%22dateModified%22%3A%222022-11-04T15%3A27%3A39Z%22%7D%7D%2C%7B%22key%22%3A%225K79Z2QE%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gold%20et%20al.%22%2C%22parsedDate%22%3A%222019-10%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGold%2C%20B.%20M.%2C%20Parekh%2C%20D.%20R.%2C%20Kearney%2C%20D.%20L.%20et%20al.%20%282019%29.%20Forme%20Fruste%20cor%20triatriatum%20dexter%20by%20transesophageal%20echocardiography%20and%20its%20impact%20on%20percutaneous%20heart%20procedures%3A%20a%20case%20series.%20%26lt%3Bi%26gt%3BCASE%20%28Phila%29%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%2C%20189%26%23x2013%3B199.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.case.2019.05.004%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.case.2019.05.004%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Forme%20Fruste%20cor%20triatriatum%20dexter%20by%20transesophageal%20echocardiography%20and%20its%20impact%20on%20percutaneous%20heart%20procedures%3A%20a%20case%20series%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20M.%22%2C%22lastName%22%3A%22Gold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dhaval%20R.%22%2C%22lastName%22%3A%22Parekh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debra%20L.%22%2C%22lastName%22%3A%22Kearney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20V.%22%2C%22lastName%22%3A%22Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20F.%22%2C%22lastName%22%3A%22Stainback%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Oct%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.case.2019.05.004%22%2C%22ISSN%22%3A%222468-6441%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%22X6Y3USZ6%22%2C%222K4N54U2%22%2C%22K6JKEATQ%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222022-02-17T16%3A55%3A56Z%22%7D%7D%2C%7B%22key%22%3A%2268MR768S%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fish%22%2C%22parsedDate%22%3A%222018-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BFish%26lt%3B%5C%2Fstrong%26gt%3B%2C%20R.%20D.%20%282018%29.%20Transcatheter%20aortic%20valve%20replacement%3A%20What%20really%20matters%20for%20women%3F%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B45%26lt%3B%5C%2Fi%26gt%3B%2C%20236%26%23x2013%3B237.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-18-6676%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-18-6676%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transcatheter%20aortic%20valve%20replacement%3A%20What%20really%20matters%20for%20women%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Aug%202018%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-18-6676%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-11-03T19%3A31%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22Y78BZTXG%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Feng%20et%20al.%22%2C%22parsedDate%22%3A%222018-02-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFeng%2C%20Y.%2C%20Zhao%2C%20Z.-G.%2C%20Baccaro%2C%20J.%20et%20al.%20%282018%29.%20First-in-man%20implantation%20of%20a%20pre-packaged%20self-expandable%20dry-tissue%20transcatheter%20aortic%20valve.%20%26lt%3Bi%26gt%3BEur%20Heart%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B39%26lt%3B%5C%2Fi%26gt%3B%2C%20713.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Feurheartj%5C%2Fehx587%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Feurheartj%5C%2Fehx587%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22First-in-man%20implantation%20of%20a%20pre-packaged%20self-expandable%20dry-tissue%20transcatheter%20aortic%20valve%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuan%22%2C%22lastName%22%3A%22Feng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhen-Gang%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Baccaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%20Frank%22%2C%22lastName%22%3A%22Zeng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mao%22%2C%22lastName%22%3A%22Chen%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Feb%2021%2C%202018%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Feurheartj%5C%2Fehx587%22%2C%22ISSN%22%3A%221522-9645%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222018-04-26T21%3A14%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22MBY2FDM7%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nascimbene%20et%20al.%22%2C%22parsedDate%22%3A%222015-04%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNascimbene%2C%20A.%2C%20Azpurua%2C%20F.%2C%20Livesay%2C%20J.%20J.%20et%20al.%20%282015%29.%20Transcatheter%20aortic%20valve%20implantation%20despite%20challenging%20vascular%20access.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B42%26lt%3B%5C%2Fi%26gt%3B%2C%20144%26%23x2013%3B147.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-13-4383%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14503%5C%2FTHIJ-13-4383%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transcatheter%20aortic%20valve%20implantation%20despite%20challenging%20vascular%20access%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelo%22%2C%22lastName%22%3A%22Nascimbene%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federico%22%2C%22lastName%22%3A%22Azpurua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20J.%22%2C%22lastName%22%3A%22Livesay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zvonimir%22%2C%22lastName%22%3A%22Krajcer%22%7D%5D%2C%22abstractNote%22%3A%22We%20describe%20transcatheter%20aortic%20valve%20implantation%20in%20a%20patient%20who%20had%20severe%20peripheral%20artery%20disease.%20The%20patient%26%23039%3Bs%20vascular%20condition%20required%20additional%20preliminary%20peripheral%20intervention%20to%20enable%20adequate%20vascular%20access.%20A%2078-year-old%20man%20with%20severe%20aortic%20stenosis%2C%20substantial%20comorbidities%2C%20and%20severe%20heart%20failure%20symptoms%20was%20referred%20for%20aortic%20valve%20replacement.%20The%20patient%26%23039%3Bs%2020-mm%20aortic%20annulus%20necessitated%20the%20use%20of%20a%2023-mm%20Edwards%20Sapien%20valve%20inserted%20through%20a%2022F%20sheath%2C%20which%20itself%20needed%20a%20vessel%20diameter%20of%20at%20least%207%20mm%20for%20percutaneous%20delivery.%20The%20left%20common%20femoral%20artery%20was%20selected%20for%20valve%20delivery.%20The%20left%20iliac%20artery%20and%20infrarenal%20aorta%20underwent%20extensive%20intervention%20to%20achieve%20an%20intraluminal%20diameter%20larger%20than%207%20mm.%20After%20aortic%20valvuloplasty%2C%20valve%20deployment%20was%20successful%2C%20and%20the%20transaortic%20gradient%20decreased%20from%2040%20mmHg%20to%20less%20than%205%20mmHg.%20The%20patient%20was%20discharged%20from%20the%20hospital%204%20days%20postoperatively.%20We%20conclude%20that%20transcatheter%20aortic%20valve%20implantation%20can%20be%20successfully%20performed%20in%20patients%20with%20obstructed%20vascular%20access%2C%20including%20stenosis%20of%20the%20infrarenal%20aorta%20and%20the%20subclavian%20and%20coronary%20arteries.%22%2C%22date%22%3A%22Apr%202015%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.14503%5C%2FTHIJ-13-4383%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%223WHLRQCH%22%2C%22YRK99JHR%22%2C%22RB8ZRZCJ%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222022-05-12T20%3A44%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22NZNDM6VV%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fish%20et%20al.%22%2C%22parsedDate%22%3A%222013-09-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bstrong%26gt%3BFish%26lt%3B%5C%2Fstrong%26gt%3B%2C%20R.%20D.%2C%20Paniagua%2C%20D.%2C%20Ure%26%23xF1%3Ba%2C%20P.%20et%20al.%20%282013%29.%20The%20Colibri%20heart%20valve%3A%20theory%20and%20practice%20in%20the%20achievement%20of%20a%20low-profile%2C%20pre-mounted%2C%20pre-packaged%20TAVI%20valve.%20%26lt%3Bi%26gt%3BEuroIntervention%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B9%20Suppl%26lt%3B%5C%2Fi%26gt%3B%2C%20S111-114.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4244%5C%2FEIJV9SSA23%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4244%5C%2FEIJV9SSA23%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Colibri%20heart%20valve%3A%20theory%20and%20practice%20in%20the%20achievement%20of%20a%20low-profile%2C%20pre-mounted%2C%20pre-packaged%20TAVI%20valve%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Paniagua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pedro%22%2C%22lastName%22%3A%22Ure%5Cu00f1a%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernard%22%2C%22lastName%22%3A%22Chevalier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22Sep%2010%2C%202013%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.4244%5C%2FEIJV9SSA23%22%2C%22ISSN%22%3A%221969-6213%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%22MGN9A7SF%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222018-05-02T21%3A16%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22ANBCDZA2%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fernandes%20et%20al.%22%2C%22parsedDate%22%3A%222012%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFernandes%2C%20M.%20R.%2C%20%26lt%3Bstrong%26gt%3BFish%26lt%3B%5C%2Fstrong%26gt%3B%2C%20R.%20D.%2C%20Canales%2C%20J.%20et%20al.%20%282012%29.%20Restoration%20of%20microcirculatory%20patency%20after%20myocardial%20infarction%3A%20results%20of%20current%20coronary%20interventional%20strategies%20and%20techniques.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B39%26lt%3B%5C%2Fi%26gt%3B%2C%20342%26%23x2013%3B350%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Restoration%20of%20microcirculatory%20patency%20after%20myocardial%20infarction%3A%20results%20of%20current%20coronary%20interventional%20strategies%20and%20techniques%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marlos%20R.%22%2C%22lastName%22%3A%22Fernandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Canales%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Aliota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guilherme%20V.%22%2C%22lastName%22%3A%22Silva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emerson%20C.%22%2C%22lastName%22%3A%22Perin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Macarthur%20A.%22%2C%22lastName%22%3A%22Elayda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20M.%22%2C%22lastName%22%3A%22Wilson%22%7D%5D%2C%22abstractNote%22%3A%22We%20sought%20to%20evaluate%20the%20restoration%20of%20microcirculatory%20patency%20after%20primary%20percutaneous%20coronary%20intervention%20%28PCI%29%20in%20an%20unselected%20cohort%20of%20patients%20at%20a%20tertiary%20center.We%20retrospectively%20evaluated%20distributions%20of%20the%20Thrombolysis%20in%20Myocardial%20Infarction%20%28TIMI%29%20myocardial%20perfusion%20grade%20%28TMPG%29%20and%20the%20myocardial%20blush%20grade%20%28MBG%29%20in%20all%20primary%20PCI%20procedures%20performed%20at%20our%20institution%20during%202008.%20We%20defined%20optimal%20microvascular%20perfusion%20as%20simultaneous%20TMPG%203%20and%20MBG%203%20at%20procedure%26%23039%3Bs%20end.Ninety-nine%20patients%20%28mean%20age%2C%2061.5%20%5Cu00b1%2012.7%20yr%3B%2064%20men%29%20underwent%20primary%20PCI.%20Microvascular%20perfusion%20was%20optimal%20in%2069%20patients%20%2869.7%25%29%20and%20was%20associated%20with%20lower%20peaks%20of%20enzymes%20than%20those%20occurring%20in%20patients%20with%20suboptimal%20perfusion.%20When%20optimal%20microvascular%20perfusion%20was%20achieved%2C%20early%20spontaneous%20recanalization%20was%20more%20frequently%20observed%2C%20as%20expressed%20by%20a%20higher%20frequency%20of%20TIMI-3%20flow%20%2834.8%25%20vs%2010%25%3B%20P%3D0.006%29%2C%20TMPG%203%20%2826%25%20vs%203.3%25%3B%20P%3D0.004%29%2C%20and%20MBG%203%20%2824.6%25%20vs%203.3%25%3B%20P%3D0.004%29%20on%20the%20initial%20angiogram%20before%20primary%20PCI.%20A%20higher%20frequency%20of%20MBG%203%20%2850%25%20vs%2020%25%3B%20P%3D0.005%29%20was%20seen%20after%20initial%20recanalization%20in%20patients%20with%20optimal%20microvascular%20perfusion.%20Multiple%20regression%20analysis%20showed%20that%20MBG%20after%20initial%20recanalization%20and%20the%20use%20of%20drug-eluting%20stents%20were%20associated%20with%20optimal%20perfusion.Despite%20successful%20recanalization%20of%20the%20culprit%20coronary%20artery%2C%20optimal%20microvascular%20perfusion%20was%20achieved%20in%20less%20than%2075%25%20of%20the%20patients.%20Restoration%20of%20the%20microvasculature%20was%20associated%20with%20smaller%20infarcts.%20Procedure-related%20variables%20associated%20with%20suboptimal%20perfusion%20were%20unlikely%20to%20be%20causative.%22%2C%22date%22%3A%222012%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%228HHBIBI6%22%2C%222K4N54U2%22%2C%22NMBVXFVC%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222021-08-21T14%3A22%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22KIAJFC7I%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cevik%20et%20al.%22%2C%22parsedDate%22%3A%222011%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BCevik%2C%20C.%2C%20Nugent%2C%20K.%2C%20Meyerrose%2C%20G.%20et%20al.%20%282011%29.%20Rosuvastatin%20therapy%20does%20not%20affect%20serum%20MMP-13%20or%20TIMP-1%20levels%20in%20hypercholesterolemic%20patients.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%2C%20229%26%23x2013%3B233%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rosuvastatin%20therapy%20does%20not%20affect%20serum%20MMP-13%20or%20TIMP-1%20levels%20in%20hypercholesterolemic%20patients%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cihan%22%2C%22lastName%22%3A%22Cevik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%22%2C%22lastName%22%3A%22Nugent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Meyerrose%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohammad%22%2C%22lastName%22%3A%22Otahbachi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cemil%22%2C%22lastName%22%3A%22Izgi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Lyte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%5D%2C%22abstractNote%22%3A%22Matrix%20metalloproteinases%20degrade%20the%20collagen%20content%20of%20atherosclerotic%20plaque%20and%20reduce%20plaque%20stability.%20In%20tissue%20sections%20of%20atherosclerotic%20plaque%2C%20the%20expression%20of%20matrix%20metalloproteinases%20is%20increased.%203-Hydroxy-3-methylglutaryl%20coenzyme%20A%20reductase%20inhibitors%20%28statins%29%20decrease%20the%20tissue%20expression%20of%20matrix%20metalloproteinases-1%2C%20-2%2C%20-3%2C%20and%20-9%20in%20atheromatous%20plaque%20by%20attenuating%20the%20inflammatory%20process%20that%20leads%20to%20increased%20expression.%20However%2C%20it%20is%20not%20known%20whether%20statins%20decrease%20levels%20of%20matrix%20metalloproteinase-13--an%20enzyme%20crucial%20to%20the%20initiation%20of%20collagen%20degradation-as%20part%20of%20their%20plaque-stabilizing%20effect.We%20prospectively%20examined%20the%20effect%20of%20statin%20therapy%20on%20serum%20levels%20of%20matrix%20metalloproteinase-13%2C%20tissue%20inhibitor%20of%20metalloproteinase-1%2C%20and%20low-density-lipoprotein%20cholesterol%20in%2014%20patients%20with%20hypercholesterolemia.%20All%20were%20at%20low%20risk%20for%20adverse%20cardiovascular%20events%20and%20were%20given%2020%20mg%5C%2Fd%20of%20rosuvastatin%20for%204%20weeks.%20Post-therapy%20levels%20of%20matrix%20metalloproteinase-13%20and%20tissue%20inhibitor%20of%20metalloproteinase-1%20were%20compared%20with%20baseline%20levels.%20Although%20low-density-lipoprotein%20cholesterol%20levels%20were%20significantly%20decreased%20in%20the%2014%20patients%20%28mean%20baseline%20level%2C%20152%20%5Cu00b1%2021%20mg%5C%2FdL%20vs%20mean%20post-therapy%20level%2C%2073%20%5Cu00b1%2045%20mg%5C%2FdL%3B%20P%20%26lt%3B%200.001%29%2C%20matrix%20metalloproteinase-13%20and%20tissue%20inhibitor%20of%20metalloproteinase-1%20levels%20were%20unchanged%20%28matrix%20metalloproteinase-13%2C%200.295%20%5Cu00b1%200.06%20ng%5C%2FmL%20vs%200.323%20%5Cu00b1%200.11%20ng%5C%2FmL%2C%20P%20%3D%200.12%3B%20and%20tissue%20inhibitor%20of%20metalloproteinase-1%2C%20400.8%20%5Cu00b1%2043.4%20ng%5C%2FmL%20vs%20395.3%20%5Cu00b1%2047.5%20ng%5C%2FmL%2C%20P%20%3D%200.26%29.%20We%20conclude%20that%20even%20though%20there%20was%20a%20decrease%20in%20low-density-lipoprotein%20cholesterol%2C%20short-term%2C%20high-dose%20rosuvastatin%20therapy%20has%20no%20effect%20on%20matrix%20metalloproteinase-13%20and%20tissue%20inhibitor%20of%20metalloproteinase-1%20levels%20in%20hypercholesterolemic%20patients.%20However%2C%20further%20investigation%20is%20warranted.%22%2C%22date%22%3A%222011%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222018-04-26T21%3A14%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22CLZT6ZCG%22%2C%22library%22%3A%7B%22id%22%3A4862227%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tambaca%20et%20al.%22%2C%22parsedDate%22%3A%222011%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BTambaca%2C%20J.%2C%20Canic%2C%20S.%2C%20Kosor%2C%20M.%20et%20al.%20%282011%29.%20Mechanical%20behavior%20of%20fully%20expanded%20commercially%20available%20endovascular%20coronary%20stents.%20%26lt%3Bi%26gt%3BTex%20Heart%20Inst%20J%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%2C%20491%26%23x2013%3B501%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mechanical%20behavior%20of%20fully%20expanded%20commercially%20available%20endovascular%20coronary%20stents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josip%22%2C%22lastName%22%3A%22Tambaca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suncica%22%2C%22lastName%22%3A%22Canic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mate%22%2C%22lastName%22%3A%22Kosor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20David%22%2C%22lastName%22%3A%22Fish%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Paniagua%22%7D%5D%2C%22abstractNote%22%3A%22The%20mechanical%20behavior%20of%20endovascular%20coronary%20stents%20influences%20their%20therapeutic%20efficacy.%20Through%20computational%20studies%2C%20researchers%20can%20analyze%20device%20performance%20and%20improve%20designs.%20We%20developed%20a%201-dimensional%20finite%20element%20method%2C%20net-based%20algorithm%20and%20used%20it%20to%20analyze%20the%20effects%20of%20radial%20loading%20and%20bending%20in%20commercially%20available%20stents.%20Our%20computational%20study%20included%20designs%20modeled%20on%20the%20Express%2C%20Cypher%2C%20Xience%2C%20and%20Palmaz%20stents.We%20found%20that%20stents%20that%20did%20not%20fully%20expand%20were%20less%20rigid%20than%20the%20fully%20expanded%20stents%20and%2C%20therefore%2C%20exhibited%20larger%20displacement.%20Stents%20with%20an%20open-cell%20design%2C%20such%20as%20Express-like%20or%20Xience-like%20stents%2C%20had%20a%20higher%20bending%20flexibility.%20Stents%20with%20in-phase%20circumferential%20rings%2C%20such%20as%20the%20Xience-like%20stent%2C%20had%20the%20smallest%20longitudinal%20extension%20when%20exposed%20to%20radial%20compression%20forces.%20Thus%2C%20the%20open-cell%20model%20that%20had%20in-phase%20circumferential%20rings%20connected%20by%20straight%20horizontal%20struts%20exhibited%20radial%20stiffness%2C%20bending%20flexibility%2C%20and%20the%20smallest%20change%20in%20stent%20length%20during%20radial%20forcing.%20The%20Palmaz-like%20stent%20was%20the%20most%20rigid%20of%20all.%20These%20findings%20are%20supported%20by%20clinical%20experience.Computer%20simulations%20of%20the%20mechanical%20properties%20of%20endovascular%20stents%20offer%20sophisticated%20insights%20into%20the%20mechanical%20behavior%20of%20different%20stent%20designs%20and%20should%20be%20used%20whenever%20possible%20to%20help%20physicians%20decide%20which%20stent%20is%20best%20for%20treating%20a%20given%20lesion.%20Our%201-dimensional%20finite%20element%20method%20model%20is%20incomparably%20simpler%2C%20faster%2C%20and%20more%20accurate%20than%20the%20classical%203-dimensional%20approaches.%20It%20can%20facilitate%20stent%20design%20and%20may%20aid%20in%20stent%20selection%20in%20the%20clinical%20setting.%22%2C%22date%22%3A%222011%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221526-6702%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22YRK99JHR%22%2C%22MGN9A7SF%22%2C%228PULYTSK%22%5D%2C%22dateModified%22%3A%222018-05-02T20%3A49%3A36Z%22%7D%7D%5D%7D
Perin, E. C., Borow, K. M., Henry, T. D. et al. (2023). Randomized trial of targeted transendocardial mesenchymal precursor cell therapy in patients with heart failure. J Am Coll Cardiol 81, 849–863. https://doi.org/10.1016/j.jacc.2022.11.061.
Kherallah, R. Y., Harrison, D., Preventza, O. et al. (2021). Transcatheter aortic valve replacement after chest radiation: A propensity-matched analysis. Int J Cardiol 329, 50–55. https://doi.org/10.1016/j.ijcard.2020.12.054.
Gold, B. M., Parekh, D. R., Kearney, D. L. et al. (2019). Forme Fruste cor triatriatum dexter by transesophageal echocardiography and its impact on percutaneous heart procedures: a case series. CASE (Phila) 3, 189–199. https://doi.org/10.1016/j.case.2019.05.004.
Fish, R. D. (2018). Transcatheter aortic valve replacement: What really matters for women? Tex Heart Inst J 45, 236–237. https://doi.org/10.14503/THIJ-18-6676.
Feng, Y., Zhao, Z.-G., Baccaro, J. et al. (2018). First-in-man implantation of a pre-packaged self-expandable dry-tissue transcatheter aortic valve. Eur Heart J 39, 713. https://doi.org/10.1093/eurheartj/ehx587.
Nascimbene, A., Azpurua, F., Livesay, J. J. et al. (2015). Transcatheter aortic valve implantation despite challenging vascular access. Tex Heart Inst J 42, 144–147. https://doi.org/10.14503/THIJ-13-4383.
Fish, R. D., Paniagua, D., Ureña, P. et al. (2013). The Colibri heart valve: theory and practice in the achievement of a low-profile, pre-mounted, pre-packaged TAVI valve. EuroIntervention 9 Suppl, S111-114. https://doi.org/10.4244/EIJV9SSA23.
Fernandes, M. R., Fish, R. D., Canales, J. et al. (2012). Restoration of microcirculatory patency after myocardial infarction: results of current coronary interventional strategies and techniques. Tex Heart Inst J 39, 342–350
Cevik, C., Nugent, K., Meyerrose, G. et al. (2011). Rosuvastatin therapy does not affect serum MMP-13 or TIMP-1 levels in hypercholesterolemic patients. Tex Heart Inst J 38, 229–233
Tambaca, J., Canic, S., Kosor, M. et al. (2011). Mechanical behavior of fully expanded commercially available endovascular coronary stents. Tex Heart Inst J 38, 491–501

Recent News

The Texas Heart Institute Fellowship Program Congratulates 2024 Cardiology Graduates

On June 7, The Texas Heart Institute honored 11 graduates of its Cardiovascular Disease Fellowship and subspecialty cardiology fellowship programs....

The Texas Heart Institute Fellowship Programs Honor 2023 Graduates

The Texas Heart Institute recently celebrated the graduation of 13 outstanding cardiologists from its Cardiovascular Disease Fellowship and subspecialty fellowship...

Professional Staff of The Texas Heart Institute Named Super Doctors® in Texas Monthly

Texas Monthly’s annual Super Doctors® list is out on the newsstands this month and honors professionals who have been recognized...