Mohammad Saeed, MD

Dr. Saeed previously served as program director of the Clinical EP Fellowship and his research work in better understanding and treatment of arrhythmias has been extensively published and presented both nationally and internationally.

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Dr. Saaed’s special interests include: implantation of pacemakers, implantable defibrillators, biventricular devices and ablation of complex cardiac arrhythmias including atrial fibrillation. He provides fellows with an important training environment on treatment and prevention of cardiovascular arrhythmias. Dr. Mohammad Saeed is a diplomate of the American Board of Internal Medicine, Cardiovascular Diseases, Clinical Cardiac Electrophysiology and Fellow American College of Cardiology. Dr. Saeed received his MD from the Aga Khan University in Karachi, Pakistan. He continued his subspecialty training in cardiovascular disease at the University of Wisconsin and Tufts New England Medical Center and is currently a Clinical Assistant Professor of Medicine at Baylor College of Medicine.

 

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Texas Heart Institute Positions

  • Teaching Staff, Cardiovascular Disease Fellowship
  • Teaching Staff, Clinical Cardiac Electrophysiology Fellowship
  • Section Editor, Structural Heart Disease, Texas Heart Institute Journal

Current Projects

  • Course Director
  • The Ali Massumi Cardiac Arrhythmia Symposium

Interests

  • Cardiology
  • Electrophysiology

Education

  • Medical School:

    Aga Khan University Medical College

  • Internship:

    Aga Khan University Medical College

  • Residency:

    University of Wisconsin Hospitals

  • Fellowships:

    Tufts – New England Medical Center

Academic & Clinical Affiliations

Publications

4862227 8J9J98DL 1 alternatives-to-animal-experimentation 10 date desc Saeed 2079 https://www.texasheart.org/wp-content/plugins/zotpress/
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Haddadin, F., Majmundar, M., Jabri, A. et al. (2022). Clinical outcomes and predictors of complications in patients undergoing leadless pacemaker implantation. Heart Rhythm 19, 1289–1296. https://doi.org/10.1016/j.hrthm.2022.03.1226.
Ganapathy, A. V., Nazeri, A., Ashton, J. et al. (2021). Contact-force recovery predicts the absence of cardiac perforation during steam pops. J Interv Card Electrophysiol 61, 181–186. https://doi.org/10.1007/s10840-020-00794-y.
Basu-Ray, I., Khanra, D., Shah, S. K. et al. (2021). Meta-analysis comparing outcomes of catheter ablation for ventricular arrhythmia in ischemic versus nonischemic cardiomyopathy. Pacing Clin Electrophysiol 44, 54–62. https://doi.org/10.1111/pace.14129.
John, M., Post, A., Burkland, D. A. et al. (2020). Confirming pericardial access by using impedance measurements from a micropuncture needle. Pacing Clin Electrophysiol 43, 593–601. https://doi.org/10.1111/pace.13927.
Hale, Z. D., Greet, B. D., Burkland, D. A. et al. (2020). Slow-pathway visualization by using voltage-time relationship: A novel technique for identification and fluoroless ablation of atrioventricular nodal reentrant tachycardia. J Cardiovasc Electrophysiol 31, 1430–1435. https://doi.org/10.1111/jce.14481.
Basu Ray, I., Khanra, D., Shah, S. et al. (2020). Meta-analysis comparing WatchmanTM and Amplatzer devices for stroke prevention in atrial fibrillation. Front Cardiovasc Med 7, 89. https://doi.org/10.3389/fcvm.2020.00089.
Liu, J., Shah, S. K., Basu-Ray, I. et al. (2019). QT prolongation in HIV-positive patients: Review article. Indian Heart J 71, 434–439. https://doi.org/10.1016/j.ihj.2019.11.259.
Allison, J., Saeed, M. and Birnbaum, Y. (2019). An interesting ECG in a patient with a dual chamber pacemaker. J Electrocardiol 56, 7–9. https://doi.org/10.1016/j.jelectrocard.2019.06.006.
Postalian, A., Birnbaum, Y. and Saeed, M. (2018). Chest radiograph clarifies an electrocardiographic abnormality. Tex Heart Inst J 45, 192–193. https://doi.org/10.14503/THIJ-18-6694.
Sanders, P., Connolly, A. T., Nabutovsky, Y. et al. (2018). Increased Hospitalizations and Overall Healthcare Utilization in Patients Receiving Implantable Cardioverter-Defibrillator Shocks Compared With Antitachycardia Pacing. JACC Clin Electrophysiol 4, 243–253. https://doi.org/10.1016/j.jacep.2017.09.004.

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