Under the direction of Dr. Jie Cheng, the research goals of the Electrophysiology (EP) Research Lab are: (1) to elucidate the pathophysiological mechanisms of various arrhythmias; (2) to develop new lines of inquiry in arrhythmia research using novel technology such as optical mapping systems; and (3) to develop new therapeutic strategies to treat various arrhythmias.
- Non-cholinergic vagal effects on atrial electrophysiological properties and vulnerability to atrial fibrillation
- Role of cytoskeletal proteins in arrhythmias
- Use of stem cell therapy to restore electrical activity in hibernating heart
- Proarrhythmic effects of B-type natriuretic peptide on failing heart
- Genetic screening in LQTS and Brugada Syndrome
The following achievements represent the current research in the EP Basic Research Laboratory:
- Defined that the action of a novel peptide (small protein), vasoactive intestine polypeptide (VIP), is vagally mediated and leads to the development of atrial fibrillation in animal models.
- Demonstrated the proarrhythmic effects of a peptide, brain natriuretic peptide (BNP), which can be detected in the blood of a patient population and confirmed the effects of BNP in an animal model.
- Jie Cheng, MD, PhD, FACC – Director
- Yutao Xi, MD, PhD – Research Associate
- Junping Sun, MD, PhD – Research Fellow
- Shahrzad Abbasi, MS – Senior Research Assistant
Heart Rhythm Society
Agency: American Heart Association Grant-in-Aid
Principal Investigator: Jie Cheng, MD, PhD
Title: Mechanisms underlying vasoactive intestine polypeptide's effects on atrial vulnerability to fibrillation
Contact Information and Location
Electrophysiology Basic Research Laboratory
Jie Cheng, MD, PhD
PO Box 20345
Houston, TX 77225-0345