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Heart Watch - articles from THI's research newsletter

Reporter Gene Imaging Can be Used for Long-term Monitoring of Transplanted Cells in the Pig Heart
Perin, EC; Willerson, JT. Heart Watch 2012 Winter;1.

Cell Therapy With Aldehyde Dehydrogenase Cells Shows Promise in Patients With Advanced Ischemic Heart Failure
Perin, EC; Willerson, JT. Heart Watch 2012 Spring;2.

Cell Therapy With Aldehyde Dehydrogenase Bright Cells May Benefit Patients With Critical Limb Ischemia
Perin, EC; Willerson, JT. Heart Watch 2011 Fall;3.

FOCUS-HF Trial Shows Cell Therapy Is Safe and Benefits Patients With Ischemic Heart Failure
Perin, EC; Willerson, JT. Heart Watch 2011 Summer;2.

Researchers Use Gadonanotubes for In Vivo Tracking of Stem Cells
Tran, L; Perin, EC; Willerson, JT. Heart Watch 2011 Winter;1.

Cardiovascular Cell Therapy Research Network Is Enrolling Patients
Perin, EC; Willerson, JT. Heart Watch 2010 Summer;6.

THI at St. Luke’s Receives Grant for Combined Stem Cell and Heart Assist Device Therapy
Gregoric, I; Kar, B; Perin, EC. Heart Watch 2010 Spring;3.

The Texas Heart Institute at St. Luke's Episcopal Hospital Continues at the Forefront of Stem Cell Therapy
Perin, EC; Willerson, JT. Heart Watch 2009 Spring;1.

Patient Receives Allogeneic Mesenchymal Precursor Cells to Treat AMI
Perin, EC.
Heart Watch 2008 Summer;2.

Remote-Controlled Magnetic Catheter Promises to Improve Delivery of Therapeutic Stem Cells to Damaged Myocardium
Perin EC.
Heart Watch. 2007 Spring;1.

New Clinical Trial Evaluates Promising Stem Cell Therapy for Peripheral Vascular Disease (PDF)
Perin EC.
Heart Watch. 2006 Fall;4.

First Clinical Trial Will Evaluate New Stem Cell Technology for Heart Failure Therapy (PDF)
Perin EC.
Heart Watch. 2006 Spring;1.

Texas Heart Institute Establishes Center to Coordinate Stem Cell Research (PDF)
Willerson JT, Perin EC.
Heart Watch. 2005 Spring;5.

Peer Reviewed Articles

2013  

Madonna R, Taylor DA, Geng YJ, De Caterina R, Shelat H, Perin EC, Willerson, JT. Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia. Circ Res. (2013) Epub 2013 Jun 18. PMID: 23780385 

2012

Perin, E.C., J.T. Willerson, C.J. Pepine, T.D. Henry, S.G. Ellis, D.X. Zhao, G.V. Silva, D. Lai, J.D. Thomas, M.W. Kronenberg, A.D. Martin, R.D. Anderson, J.H. Traverse, M.S. Penn, S. Anwaruddin, A.K. Hatzopoulos, A.P. Gee, D.A. Taylor, C.R. Cogle, D. Smith, L. Westbrook, J. Chen, E. Handberg, R.E. Olson, C. Geither, S. Bowman, J. Francescon, S. Baraniuk, L.B. Piller, L.M. Simpson, C. Loghin, D. Aguilar, S. Richman, C. Zierold, J. Bettencourt, S.L. Sayre, R.W. Vojvodic, S.I. Skarlatos, D.J. Gordon, R.F. Ebert, M. Kwak, L.A. Moye, and R.D. Simari, Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial. JAMA, 2012. 307(16): p. 1717-26.

Perin, E.C., G.V. Silva, Y. Zheng, A. Gahremanpour, J. Canales, D. Patel, M.R. Fernandes, L.H. Keller, X. Quan, S.A. Coulter, W.H. Moore, J.P. Herlihy, and J.T. Willerson, Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure. Am Heart J, 2012. 163(3): p. 415-421 e1.

 

2011

Traverse, J.H., T.D. Henry, S.G. Ellis, C.J. Pepine, J.T. Willerson, D.X. Zhao, J.R. Forder, B.J. Byrne, A.K. Hatzopoulos, M.S. Penn, E.C. Perin, K.W. Baran, J. Chambers, C. Lambert, G. Raveendran, D.I. Simon, D.E. Vaughan, L.M. Simpson, A.P. Gee, D.A. Taylor, C.R. Cogle, J.D. Thomas, G.V. Silva, B.C. Jorgenson, R.E. Olson, S. Bowman, J. Francescon, C. Geither, E. Handberg, D.X. Smith, S. Baraniuk, L.B. Piller, C. Loghin, D. Aguilar, S. Richman, C. Zierold, J. Bettencourt, S.L. Sayre, R.W. Vojvodic, S.I. Skarlatos, D.J. Gordon, R.F. Ebert, M. Kwak, L.A. Moye, and R.D. Simari, Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial. JAMA, 2011. 306(19): p. 2110-9.

Perin, E.C., M. Tian, F.C. Marini, 3rd, G.V. Silva, Y. Zheng, F. Baimbridge, X. Quan, M.R. Fernandes, A. Gahremanpour, D. Young, V. Paolillo, U. Mukhopadhyay, A.T. Borne, R. Uthamanthil, D. Brammer, J. Jackson, W.K. Decker, A.M. Najjar, M.W. Thomas, A. Volgin, B. Rabinovich, S. Soghomonyan, H.J. Jeong, J.M. Rios, D. Steiner, S. Robinson, O. Mawlawi, T. Pan, J. Stafford, V. Kundra, C. Li, M.M. Alauddin, J.T. Willerson, E. Shpall, and J.G. Gelovani, Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One, 2011. 6(9): p. e22949.

Perin, E.C. and J.T. Willerson, CD34+ autologous human stem cells in treating refractory angina. Circ Res, 2011. 109(4): p. 351-2.

Gundlach, C.W.t., A. Caivano, G. Cabreira-Hansen Mda, A. Gahremanpour, W.S. Brown, Y. Zheng, B.W. McIntyre, J.T. Willerson, R.A. Dixon, E.C. Perin, and D.G. Woodside, Synthesis and evaluation of an anti-MLC1 x anti-CD90 bispecific antibody for targeting and retaining bone-marrow-derived multipotent stromal cells in infarcted myocardium. Bioconjug Chem, 2011. 22(8): p. 1706-14.

Silva, G.V., M.R. Fernandes, C.O. Cardoso, R.R. Sanz, E.M. Oliveira, P. Jimenez-Quevedo, J. Lopez, F.S. Angeli, Y. Zheng, J.T. Willerson, and E.C. Perin, A dosing study of bone marrow mononuclear cells for transendocardial injection in a pig model of chronic ischemic heart disease. Tex Heart Inst J, 2011. 38(3): p. 219-24.

Perin, E.C., G.V. Silva, D.C. Vela, Y. Zheng, F. Baimbridge, A. Gahremanpour, X. Quan, W. Hahn, J. Kim, K. Wood, and M. Kitamura, Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. J Card Fail, 2011. 17(7): p. 601-11.

Perin, E.C., G.V. Silva, T.D. Henry, M.G. Cabreira-Hansen, W.H. Moore, S.A. Coulter, J.P. Herlihy, M.R. Fernandes, B.Y. Cheong, S.D. Flamm, J.H. Traverse, Y. Zheng, D. Smith, S. Shaw, L. Westbrook, R. Olson, D. Patel, A. Gahremanpour, J. Canales, W.K. Vaughn, and J.T. Willerson, A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF). Am Heart J, 2011. 161(6): p. 1078-87 e3.

Perin, E.C., G. Silva, A. Gahremanpour, J. Canales, Y. Zheng, M.G. Cabreira-Hansen, F. Mendelsohn, N. Chronos, R. Haley, J.T. Willerson, and B.H. Annex, A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia. Catheter Cardiovasc Interv, 2011. 78(7): p. 1060-7.

Tran, L.A., R. Krishnamurthy, R. Muthupillai, G. Cabreira-Hansen Mda, J.T. Willerson, E.C. Perin, and L.J. Wilson, Gadonanotubes as magnetic nanolabels for stem cell detection. Biomaterials, 2010. 31(36): p. 9482-91.

Perin, E.C. and G.V. Silva, Cell-based therapy for chronic ischemic heart disease--a clinical perspective. Cardiovasc Ther, 2011. 29(3): p. 211-7.

2010

Perin, E.C., G.V. Silva, and J.T. Willerson, Training on the use of transendocardial delivery of biologics for cardiac regeneration. JACC Cardiovasc Interv, 2010. 3(9): p. 991.

Traverse, J.H., T.D. Henry, D.E. Vaughan, S.G. Ellis, C.J. Pepine, J.T. Willerson, D.X. Zhao, L.M. Simpson, M.S. Penn, B.J. Byrne, E.C. Perin, A.P. Gee, A.K. Hatzopoulos, D.H. McKenna, J.R. Forder, D.A. Taylor, C.R. Cogle, S. Baraniuk, R.E. Olson, B.C. Jorgenson, S.L. Sayre, R.W. Vojvodic, D.J. Gordon, S.I. Skarlatos, L.A. Moye, and R.D. Simari, LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J, 2010. 37(4): p. 412-20.

Willerson, J.T., E.C. Perin, S.G. Ellis, C.J. Pepine, T.D. Henry, D.X. Zhao, D. Lai, M.S. Penn, B.J. Byrne, G. Silva, A. Gee, J.H. Traverse, A.K. Hatzopoulos, J.R. Forder, D. Martin, M. Kronenberg, D.A. Taylor, C.R. Cogle, S. Baraniuk, L. Westbrook, S.L. Sayre, R.W. Vojvodic, D.J. Gordon, S.I. Skarlatos, L.A. Moye, and R.D. Simari, Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design. Am Heart J, 2010. 160(2): p. 215-23.

 

2009

Traverse, J.H., T.D. Henry, D.E. Vaughan, S.G. Ellis, C.J. Pepine, J.T. Willerson, D.X. Zhao, L.B. Piller, M.S. Penn, B.J. Byrne, E.C. Perin, A.P. Gee, A.K. Hatzopoulos, D.H. McKenna, J.R. Forder, D.A. Taylor, C.R. Cogle, R.E. Olson, B.C. Jorgenson, S.L. Sayre, R.W. Vojvodic, D.J. Gordon, S.I. Skarlatos, L.A. Moye, and R.D. Simari, Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J, 2009. 158(3): p. 356-63.

Silva, G.V., M.R. Fernandes, R. Madonna, F. Clubb, E. Oliveira, P. Jimenez-Quevedo, R. Branco, J. Lopez, F.S. Angeli, R. Sanz-Ruiz, W.K. Vaughn, Y. Zheng, F. Baimbridge, J. Canales, C.O. Cardoso, J.A. Assad, R. Falotico, and E.C. Perin, Comparative healing response after sirolimus- and paclitaxel-eluting stent implantation in a pig model of restenosis. Catheter Cardiovasc Interv, 2009. 73(6): p. 801-8.

Perin, E.C. and G.V. Silva, Autologous cell-based therapy for ischemic heart disease: clinical evidence, proposed mechanisms of action, and current limitations. Catheter Cardiovasc Interv, 2009. 73(3): p. 281-8.

Vela, D.C., G.V. Silva, J.A. Assad, A.L. Sousa, S. Coulter, M.R. Fernandes, E.C. Perin, J.T. Willerson, and L.M. Buja, Histopathological study of healing after allogenic mesenchymal stem cell delivery in myocardial infarction in dogs. J Histochem Cytochem, 2009. 57(2): p. 167-76.

2008

Fernandes, M.R., G.V. Silva, Y. Zheng, E.M. Oliveira, C.O. Cardoso, J. Canales, R. Sanz-Ruiz, P. Jimenez-Quevedo, F. Baimbridge, and E.C. Perin, Validation of QwikStar Catheter for left ventricular electromechanical mapping with NOGA XP system. Tex Heart Inst J, 2008. 35(3): p. 240-4.

Jimenez-Quevedo, P., G.V. Silva, R. Sanz-Ruiz, E.M. Oliveira, M.R. Fernandes, F. Angeli, J.T. Willerson, H.F. Dohmann, and E.C. Perin, [Diabetic and nondiabetic patients respond differently to transendocardial injection of bone marrow mononuclear cells: findings from prospective clinical trials in "no-option" patients]. Rev Esp Cardiol, 2008. 61(6): p. 635-9.

 

Zheng, Y., M.R. Fernandes, G.V. Silva, C.O. Cardoso, J. Canales, A. Gahramenpour, F. Baimbridge, M. da Graca Cabreira-Hansen, and E.C. Perin, Histopathological validation of electromechanical mapping in assessing myocardial viability in a porcine model of chronic ischemia. Exp Clin Cardiol, 2008. 13(4): p. 198-203.

 

Perin, E.C., G.V. Silva, J.A. Assad, D. Vela, L.M. Buja, A.L. Sousa, S. Litovsky, J. Lin, W.K. Vaughn, S. Coulter, M.R. Fernandes, and J.T. Willerson, Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction. J Mol Cell Cardiol, 2008. 44(3): p. 486-95.

 

2007

Fernandes, M.R., G.V. Silva, A. Caixeta, M. Rati, N.A. de Sousa e Silva, and E.C. Perin, Assessing intermediate coronary lesions: angiographic prediction of lesion severity on intravascular ultrasound. J Invasive Cardiol, 2007. 19(10): p. 412-6.

Abdel-Latif, A., R. Bolli, I.M. Tleyjeh, V.M. Montori, E.C. Perin, C.A. Hornung, E.K. Zuba-Surma, M. Al-Mallah, and B. Dawn, Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med, 2007. 167(10): p. 989-97.

Perin, E.C., G.V. Silva, M.R. Fernandes, T. Munger, A. Pandey, R. Sehra, M. Talcott, C.J. Bichard, J. Creed, J.W. Wong, E.M. Oliveira, Y. Zheng, J. Canales, C.O. Cardoso, M.S. Patterson, and P.W. Serruys, First experience with remote left ventricular mapping and transendocardial cell injection with a novel integrated magnetic navigation-guided electromechanical mapping system. EuroIntervention, 2007. 3(1): p. 142-8.

Book Chapters

Perin EC, Silva GV, Willerson JT. Interventional treatment of advanced ischemic heart disease. London: Springer; c2009. Chapter 7, Cellular implantation therapy: current studies, different strategies and potential applications; p. 93-128.

Perin EC, Silva GV. Cardiovascular genetics and genomics for the cardiologist. Malden, MA : Blackwell Futura; c2007. Chapter 10, Stem cell therapy for cardiovascular disease; p. 225-249.

Perin EC, Silva GV, Jimenez-Quevedo P. Common clinical dilemmas in percutaneous coronary interventions. Abingdon, UK: Informa Healthcare; c2007. Chapter 21, End-stage left ventricular failure: potential catheter-based therapeutic strategies; p. 243-252.

Stem cell delivery modalities (Chapter 1) Silva G, Perin EC, Heinl-Green AC, Clague J, Alton EW.
In: An Essential Guide to Cardiac Cell Therapy Perin EC, Silva GV and Willerson JR, eds. Informa 2006.

What are stem cells and what do they do? (Chapter 11) Silva G, Perin EC.
In: An Essential Guide to Cardiac Cell Therapy Perin EC, Silva GV, and Willerson JR, eds. Informa 2006

Myocardial revascularization: novel percutaneous approaches (Chapter 13)
Perin EC, Silva GV, Leite RS.
In: Left Ventricular Electromechanical Mapping As a Diagnostic Method Abela GS, ed. Wiley-Liss 2002


Presentations

“A Phase II Dose-Escalation Study of Allogeneic Mesenchymal Precursor Cells in Patients With Ischemic and Nonischemic Heart Failure” presented by Dr. Emerson C. Perin at the American Heart Association Scientific Sessions 2011 and posted online at www.mesoblast.com/download/363

"Stem Cells in Cardiovascular Disease - A Case Study" presented by Dr. Emerson C. Perin and posted online at Texas Heart Institute, Continuing Medical Education, March 2009

"Stem Cell Therapy in Cardiovascular Disease" presented by Dr. Emerson C. Perin in March 2008 for Clinical Update 2008, Texas Heart Institute Continuing Medical Education.

"Stem Cell Therapy in Cardiovascular Disease" presented by Dr. Emerson C. Perin in July 2007 at 7th Texas Update in Cardiovascular Advancements symposium, Texas Heart Institute Continuing Medical Education.

"Future Horizons: Stem Cell Therapy" presented by Dr. Emerson C. Perin in November 2006 at Acute and Long-term Treatment of Cardiovascular Disease: Bringing Science to the Bedside symposium.

"Bone Marrow Transplantation for Chronic Ischemic Cardiomyopathy" presented by Dr. Emerson C. Perin in February 2006 at the Inaugural Conference of the International Society for Genomics, Proteomics and Cellular Therapy.

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Updated November 2013
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