This BBC Science Club video looked at the Regenerative Medicine lab efforts to create a biological heart.
Researcher Probes Science to Building a "Bio-Artificial" Heart
of our organs contain enough stem cells to repair and regenerate
themselves after injuries. But not the heart, that most central of
muscles. And finding a way to compensate for that fact has become a
life's mission for Doris Taylor, a new arrival at the Texas Heart
Institute in Houston."
Read the interview with Angela Shah from Xconomy. (October 15, 2013)
Gov. Perry Announces $3 Million Grant to Create Center for
Cell and Organ Biotechnology
Gov. Rick Perry announced a $3 million investment through the Texas
Emerging Technology Fund (TETF) to create the Center for Cell and Organ
Biotechnology in collaboration with the Texas Heart Institute (THI) and Texas
A&M University College of Veterinary Medicine and Biomedical Sciences.
"This center represents another step toward making Texas the forefront of
biotechnology for generations to come," Gov. Perry said. Read the details in the full press release. (September 13, 2013)
Scientists renew stem cells' healing properties in mice
Scientists at THI have discovered what might be the fountain of youth for stem cells,
a method they say could be used to develop a potential treatment for elderly
patients suffering from heart and vascular diseases. "What we are doing is
restoring the older cells to a far better and more youthful functional
capability," said Dr. James T. Willerson, president of THI and the
study's principal investigator (published in Circulation Research, September 2013).
Read more from the Houston Chronicle. Also
see "Heart to Heart" July 8, 2013 for a closer look at the research.
Tissue engineering: How to build a heart
Doris Taylor doesn't take it as an insult when people call her Dr Frankenstein. Director of Regenerative Medicine Research at THI, Taylor is in the vanguard of researchers looking to engineer entire new organs, to enable transplants without the risk of rejection by the recipient's immune system. The strategy is simple enough in principle ... In practice, however, the process is beset with tremendous challenges. Read more (including video, podcast, illustrations) from Nature News (July 3, 2013).
To ease shortage of organs, grow them in a lab
Lungs and other organs for transplant are scarce. But what if there
were another way? What if you could grow a custom-made organ in a lab? .
. . "I believe the future is ... a pig matrix covered with your own
cells," says Doris Taylor of the Texas Heart Institute
in Houston. She reported creating a rudimentary beating rat heart in
2008 with the cell-replacement technique and is now applying it to a
variety of organs ... from the Houston Chronicle (June 17, 2013). See also the story in USA Today.
Repairing and Replacing Body Parts: What's Next
Researchers are exploring ways to repair, refurbish, or replace human organs
"Medicine is saving people who previously we weren't able to save," says Dr. Doris A. Taylor, director of regenerative medicine research at the Texas Heart Institute in Houston. Perhaps the ultimate goal is creating and transplanting a functioning bio-artificial heart. "We're making huge strides," Taylor says, and predicts that a transplant of one kind of bio-artificial solid complex organ will be possible within five years. Read the article from National Geographic Daily News April 15, 2013.
The Journey from Cell Culture to Bioprinting and Beyond
"Perhaps the most incredible example of Decellularized scaffold being developed besides the successful trachea is the development of laboratory grown hearts! Dr. Doris A.Taylor, now of the Texas Heart Institute and her team have developed a process for whole organ decellularization and then reseeding them successfully with cells taken from rat and pig hearts." From h+ Magazine published by Humanity+, March 27, 2013
Science Fiction Comes Alive as Researchers Grow Organs in Lab
Under this thought-provoking headline, The Wall Street Journal featured an article on the promise of regenerative medicine and the significant contributions of Dr. Doris Taylor to this emerging field. WSJ March 22, 2013
Saving lives with help from pigs and cells
Doris Taylor and her team are building new organs, hoping to reverse disease, maybe even the aging process. On the ninth floor of the Texas Heart Institute's Denton Cooley building, Doris Taylor and her team are building human hearts, with help from pigs and stem cells.
"We think a pig heart is a perfect scaffold for a human heart, based on its structure and size," says Taylor, a passionate scientist with a Ph.D. in pharmacology. — Houston Chronicle Jan. 27, 2013 [Photo credit Michael Paulsen]
THI Chosen as Biorepository for Cardiac Stem Cell Research
THI has been chosen as the Biorepository Core Lab for the
CCTRN and will be under the direction of Dr. Doris Taylor and Dr. Adrian Gee. News release December 17, 2012
Regenerative Medicine Research
Doris Taylor, PhD, FAHA, FACC, one of the world's leading
cell therapy and cardiac regeneration scientists, joins THI as Director, Regenerative Medicine Research. News release March
Cardiac regeneration scientist Doris Taylor leaves U of M for Texas
Radio interview. Minnesota Public Radio
Daily Circuit (7 min), March 7, 2012
Researchers on the verge of growing human hearts
Posted by Siva Nagarajah (August 18, 2011)
The Independent Blogs – Science & Technology
Reloading the Matrix: Doris Taylor Is Growing New Hearts
Blog entry online at CARDIOBRIEF.org (April 2, 2011)
Custom-made hearts, lungs, and kidneys could revolutionize organ transplantation
Program: Replacing Body Parts
PBS Video (13:35 min, January 26, 2011)
Stem cells and the heart
Radio interview with Dr. Doris Taylor and Dr. Eduardo Marban
From Minnesota Public Radio News-Midmorning (12/06/2010)
SoundSeen: "Bioreactors + Building Hope" with Doris Taylor
American Public Media, Program: On Being
Radio broadcast of SoundSeen: Stem Cells, Untold Stories
(52:07 min, September 30, 2010)
Building Hearts + Lengthening Telomeres: A conversation with Dr. Doris Taylor
Speaking of Faith with Krista Tippett American Public Media on YouTube.
(2:30 min, October 30, 2009)
More than a year later, heart research still beating strong
News from the Minnesota Daily (April 8, 2009)
University of Minnesota
Team Creates Rat Heart Using Cells of Baby Rats
From the Health section in the New York Times
(January 14, 2008)
To mend a failing heart
Press release from
Heart Maker, researcher Doris Taylor
Face to Face article. Minnesota Medicine magazine, May 2007
Profile: Doris Taylor, Assistant Research Professor
From the Biotechnology Institute at Biotechinstitute.org. (PDF)
A Book For Age 10 and Up
Doris Taylor: Growing a Beating Heart
With Lori Mortensen
Published by KidHaven, October 2009
Available from Amazon.
Updated October 2013